Zindaclin 1% Gel is a topical antibiotic treatment used to manage mild to moderate acne. It contains the active ingredient clindamycin phosphate, which helps to reduce acne-causing bacteria on the skin. Zindaclin works by targeting the bacteria responsible for acne, reducing inflammation and preventing new breakouts. It’s easy to apply and is typically used once daily to affected areas. Zindaclin 1% Gel is available by prescription and is an effective option for those struggling with persistent acne.
Dr Sarah Thornton MbChB, Coaching Academy diploma with distinction
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What is Zindaclin 1% gel?
Zindaclin 1% Gel is a topical medication used to treat acne, particularly mild to moderate cases. It contains clindamycin phosphate, an antibiotic that works by reducing the bacteria responsible for causing acne. This gel is applied directly to the affected skin areas, helping to decrease inflammation and prevent the formation of new spots and pimples. Zindaclin 1% Gel is typically prescribed by a doctor and is designed for daily use as part of an acne treatment regimen.
What is the active ingredient in Zindaclin 1% gel?
1g of gel contains 10mg clindamycin (1% w/w) equivalent to 11.88mg of clindamycin phosphate.
What is Zindaclin 1% gel used for?
Zindaclin 1% Gel is used for the treatment of mild to moderate acne. It is applied directly to the skin to help reduce the number of acne-causing bacteria, decrease inflammation, and prevent the formation of new spots, blackheads, and pimples. This medication is particularly effective in managing acne on the face, back, and chest.
How does Zindaclin 1% gel work?
Zindaclin 1% Gel contains the active ingredient clindamycin, an antibiotic that works by targeting and inhibiting the growth of acne-causing bacteria on the skin, particularly Propionibacterium acnes. By reducing the bacteria, Zindaclin helps to decrease inflammation, prevent the formation of new acne lesions, and promote the healing of existing spots, pimples, and blackheads. The gel alo helps to reduce excess oil production, further aiding in the management of acne.
How do you use Zindaclin 1% gel?
Apply Zindaclin Gel directly to the affected skin once a day, avoiding the surrounding healthy skin.
Before applying the gel, gently wash the affected area with mild soap, rinse with warm water, and pat dry. Apply a thin layer of the gel to the entire area where spots typically appear, rather than just individual spots.
Acne treatments often take several weeks to show noticeable improvement, so you may need to use Zindaclin Gel for several months. It may take 4 to 8 weeks to see the full effects. It's important to continue the treatment for the entire prescribed course, usually 3 to 6 months, to prevent the acne from returning.
Who should not use Zindaclin 1% gel?
Zindaclin is contraindicated in patients with a known hypersensitivity to clindamycin or any of the excipients in the product. Although cross-sensitivity to lincomycin has not been confirmed, it is advised that Zindaclin should not be used in patients with a history of sensitivity to lincomycin.
Special Warnings and Precautions
Oral and injectable clindamycin, like most antibiotics, have been linked to severe pseudomembranous colitis. Although topical clindamycin is rarely associated with this condition, treatment should be discontinued immediately if diarrhoea occurs.
Pseudomembranous colitis is typically caused by toxins produced by Clostridium difficile and is characterized by severe, persistent diarrhea and abdominal cramps. If antibiotic-associated colitis is suspected, appropriate measures should be taken, including stopping Zindaclin and possibly initiating treatment with metronidazole or vancomycin.
Response to treatment may take 4-6 weeks.
While systemic absorption from Zindaclin is low, the risk of gastrointestinal side effects should be considered, especially in patients with a history of antibiotic-associated colitis, enteritis, ulcerative colitis, or Crohn's disease.
Prolonged use may lead to resistance or overgrowth of non-susceptible bacteria or fungi, though this is rare. Cross-resistance may occur with other antibiotics such as lincomycin and erythromycin.
Avoid contact with eyes or mucous membranes; if contact occurs, rinse the area thoroughly with cool water.
Zindaclin contains propylene glycol, which may cause skin irritation, and ethanol, which may cause a burning sensation on damaged skin.
The irritation potential of Zindaclin may be increased if used under occlusion.
Use in Pregnancy and Lactation
There is no clinical data on the use of topically applied clindamycin during pregnancy. Limited data on pregnancies exposed to clindamycin by other routes do not suggest adverse effects on pregnancy or fetal health. Animal studies do not indicate harmful effects on pregnancy or development.
Clindamycin has been detected in breast milk when administered orally or parenterally. It is unknown if it is excreted in human milk following topical application. As a precaution, breastfeeding should generally be avoided while using Zindaclin.
The risks and benefits of using Zindaclin during pregnancy and lactation should be carefully weighed.
Effects on Ability to Drive and Use Machines
Not applicable.
What are the side effects with Zindaclin 1% gel?
Approximately 10% of patients using Zindaclin may experience adverse reactions, typically associated with irritant dermatitis. The likelihood of these reactions may increase if too much gel is applied. If irritation occurs, using a moisturizer may help.
Common side effects reported include dry skin, redness (erythema), and a burning sensation on the skin. Less commonly, patients may experience irritation around the eyes, worsening of acne, itching (pruritus), painful skin, or a scaly rash.
Although no cases of severe diarrhea or pseudomembranous colitis were reported in clinical trials with Zindaclin, and only a small amount of clindamycin is absorbed through the skin, there is a theoretical risk of pseudomembranous colitis based on the use of other topical clindamycin products.
Does Zindaclin 1% gel interact with other medicines?
Antagonism between erythromycin and clindamycin has been observed in vitro. Synergistic effects have been seen with metronidazole, while both antagonistic and synergistic effects have been noted with aminoglycosides.
Zindaclin 1% gel FAQs
How does acne occur?
Acne is a common skin condition caused by hormonal changes that lead to the production of excess oil, called sebum. Bacteria known as P. acnes live on the skin and feed on this sebum. The combination of excess sebum and bacteria can block pores, leading to the development of spots. Acne typically appears on the face, back, and chest.
While acne may clear up on its own, it can be painful and cause self-consciousness. Zindaclin gel is a proven treatment that reduces redness and inflammation of acne spots and helps prevent new spots from forming.
How does Zindaclin treat acne?
Zindaclin gel contains the active ingredient clindamycin phosphate, an antibiotic that stops bacteria from growing on the skin. When applied directly to acne-affected areas, it kills the bacteria and prevents them from clogging pores, reducing the likelihood of new spots. The gel also helps to reduce skin irritation, redness, and inflammation associated with acne.
Can Zindaclin be used with other acne treatments?
Zindaclin is a topical antibiotic treatment that should not be combined with other oral or topical antibiotic treatments. However, combining Zindaclin with a non-antibiotic acne treatment, such as Acnecide gel, Skinoren cream, Differin, or Epiduo gel, can produce better results than using either treatment alone.
What should I know before using Zindaclin?
Before using Zindaclin Gel, it’s important to be aware of all the warnings and precautions detailed in the Patient Information Leaflet. If you have a history of inflammatory bowel disease or have experienced diarrhea due to antibiotics, consult your doctor before using Zindaclin. Additionally, Zindaclin contains about 20% ethanol, which can cause a burning sensation on damaged skin.
Can I use Zindaclin during pregnancy or while breastfeeding?
If you are pregnant or breastfeeding and suffering from acne, consult a doctor or pharmacist before using Zindaclin Gel. The active ingredient, clindamycin, can be absorbed and passed to your baby through breast milk, so breastfeeding should be avoided while using this product.
How do I use Zindaclin?
Zindaclin gel should be applied once a day directly to the affected areas of the skin. Avoid applying it to healthy skin. Wash the affected skin gently with mild soap, rinse with warm water, and pat dry before applying a thin layer of the gel over the entire area where you usually get spots.
What are the ingredients in Zindaclin?
Each tube of Zindaclin Gel contains the active ingredient clindamycin phosphate 1%. The inactive ingredients include propylene glycol, ethanol, zinc acetate, hydroxyethylcellulose, and sodium hydroxide. Be sure to familiarize yourself with these ingredients before using Zindaclin Gel.
What are the possible side effects of Zindaclin?
Zindaclin Gel may cause mild side effects such as dry, itchy, or red skin, a burning sensation, irritation around the eyes, or worsening of acne. These can often be relieved by applying an oil-free moisturizer. If side effects are severe, such as diarrhea or an allergic reaction, seek medical advice immediately.
Please make sure to read the Patient Information Leaflet thoroughly before using Zindaclin Gel.
Download patient leaflet
Checked By
Dr Sarah Thornton MbChB, Coaching Academy diploma with distinction
