7 surprising things to avoid when taking low dose naltrexone

Looking into low dose naltrexone (LDN)? Smart move. It’s a small dose with surprisingly big potential for chronic pain, autoimmune conditions, long COVID, and fatigue. The catch: LDN’s picky about what you combine it with. Wrong meds, supplements, or habits can blunt results, spike side effects, or (with opioids) cause serious trouble.

This guide walks you through 7 surprising things to avoid when taking LDN — from hidden opioid ingredients to timing slip-ups that wreck sleep. No fearmongering. Just straightforward tips to help you nail it.

Five key takeaways

1. Opioids are the big one. LDN blocks opioid receptors, so opioid painkillers can be ineffective — and may trigger sudden withdrawal in dependent users.
2. Alcohol can undo your progress (and stress the liver). Even if it’s “just a couple”, it can worsen sleep, fatigue, and liver load — all things many people are trying to improve with LDN.
3. Don’t freestyle pain relief. NSAIDs and high-dose paracetamol don’t “clash” with LDN directly, but long-term stacking can add gut/liver strain — worth a pharmacist check.
4. Consistency beats heroics. Sudden stops or big dose jumps can bring symptom rebound. Slow titration and steady timing usually wins.
5. Timing matters more than people expect. If LDN gives you vivid dreams or insomnia, it’s often a dosing-time issue — moving it earlier can be a game-changer.

Introduction

Right then, you’ve decided to explore the fascinating world of low-dose naltrexone (LDN). Brilliant! It’s a bit like discovering a secret lever in a grand, steampunk clockwork machine. This small adjustment has the potential for profound effects on conditions from autoimmune disorders and chronic pain to long COVID. But just like any precision instrument, LDN works best when you understand which other gears to keep it away from to ensure a smooth operation.

At Medical Mojo, we’re all about empowering you with the know-how to make your treatment journey a resounding success. This isn’t just a list of ‘don’ts’; it’s your trusty navigational chart, helping you steer clear of common pitfalls and unexpected interactions that could derail your progress. We’ve organised this guide to give you clear, actionable advice on what to avoid when taking low dose naltrexone, ensuring you get the maximum benefit with minimum fuss.

We’ll cover everything from the most critical opioid conflicts to more subtle dosing mistakes that could hinder your results. Understanding these key areas is essential for your safety and for allowing LDN to work its magic. Think of this as your essential manual for fine-tuning your therapy, ensuring every part of your health machinery works in perfect harmony. Let’s get started.

1. Avoid opioid medications and herbal supplements containing opioids

Low dose naltrexone (LDN) operates by briefly blocking opioid receptors in your brain and central nervous system. This action is key to its therapeutic effects, as it stimulates your body to produce more of its natural pain-relieving and mood-regulating chemicals, known as endogenous opioids or endorphins. However, because LDN is an opioid antagonist, it will actively compete with and block any external (exogenous) opioids you take, making this one of the most critical things to avoid when taking low dose naltrexone.

Combining LDN with opioid-based medications not only renders the pain relief from those medications useless but can also trigger a serious and deeply unpleasant reaction called precipitated withdrawal [1]. This occurs because naltrexone rapidly displaces opioid molecules from their receptors, leading to an abrupt onset of withdrawal symptoms like nausea, muscle aches, anxiety, and sweating. This is particularly crucial for people with conditions like fibromyalgia or long COVID, who might be prescribed opioids for pain management. Understanding the relationship between LDN and the body’s natural pain-relief system is essential; you can learn more about the connection between the immune system and endogenous opioids to see why this interaction is so important.

Why it’s a problem and what to do

The conflict is direct: LDN blocks the very receptors that opioid medications need to activate. This creates a no-win situation where pain is not controlled, and the risk of nasty side effects skyrockets.

A note on precipitated withdrawal: Unlike typical withdrawal that develops gradually after stopping an opioid, precipitated withdrawal is sudden and intense. It is a direct result of an antagonist like naltrexone forcefully evicting opioids from receptors, and it can be a significant medical event.

Practical tips for safe LDN use

To ensure your treatment is safe and effective, follow these actionable steps:

• Complete medication disclosure: Honesty is the best policy. Before starting LDN, provide your Medical Mojo pharmacist with a complete list of all medications, supplements, and even herbal remedies you are taking. This includes over-the-counter items like codeine-based cough syrups.
• Plan for acute pain: If you know you’ll need surgery or a procedure requiring opioid pain relief, have a chat with your clinician well in advance. This usually involves temporarily stopping LDN for a specific period before and after receiving the opioid.
• Explore non-opioid alternatives: Work with your healthcare provider to manage pain with other options. These can include Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), topical analgesics like lidocaine patches, physical therapy, acupuncture, or mindfulness.
• Watch for hidden opioids: Be aware that some herbal supplements contain compounds that act on opioid receptors and must be avoided. Always check the ingredients of any new supplement.

2. Avoid alcohol and high-risk drinking patterns

Combining low dose naltrexone with alcohol is a subject that requires a careful and honest chat with your clinician. While naltrexone is used in higher doses to treat alcohol use disorder, its interaction with alcohol at any dose carries potential risks, primarily concerning liver health. Naltrexone is processed by the liver, and adding alcohol—which also places a significant burden on the liver—can increase the risk of hepatotoxicity (liver damage), especially with regular or heavy consumption [2]. This is a critical factor to consider when evaluating what to avoid when taking low dose naltrexone.

Beyond liver stress, alcohol can directly counteract the benefits you seek from LDN. For instance, someone using LDN to improve sleep quality who has a nightly glass of wine may find their sleep remains disrupted, as alcohol impairs restorative sleep cycles. Similarly, for those managing conditions like long COVID or chronic fatigue, regular alcohol intake can worsen inflammation and fatigue, working against LDN’s intended effects. In weight management programmes, alcohol provides empty calories and can impair judgement, potentially derailing progress.

Why it’s a problem and what to do

The main conflict is the cumulative stress on the liver. Both substances require hepatic metabolism, and combining them, particularly with high-risk drinking patterns, elevates the risk of liver inflammation and damage over time. Additionally, alcohol can worsen symptoms that LDN is meant to alleviate, such as fatigue, brain fog, and poor sleep.

A note on central nervous system effects: Both LDN and alcohol can affect the central nervous system. Combining them may lead to increased dizziness, drowsiness, or impaired coordination, making activities like driving more dangerous. While the interaction is complex, it is a prudent reason to exercise caution—a topic often explored when discussing medications and alcohol. You can read a similar discussion about sildenafil for context on medication safety.

Practical tips for safe LDN use

To protect your liver and maximise the benefits of your treatment, consider these steps:

• Be transparent about consumption: Disclose your typical alcohol intake honestly during your Medical Mojo online health assessment. This allows your clinician to assess your liver health risk and provide personalised advice.
• Prioritise liver health: If you have a history of regular alcohol use, your clinician may recommend baseline Liver Function Tests (LFTs) before you start LDN and periodic monitoring throughout your treatment.
• Abstain or limit significantly: The safest approach is to avoid alcohol while on LDN. If you choose to drink, limit it to an absolute minimum, such as one or two units per week, and never binge drink.
• Time your doses wisely: If you do have a rare, occasional drink, try to create as much space as possible between your LDN dose and alcohol consumption (ideally 12 hours or more) to reduce the immediate load on your liver.
• Monitor for warning signs: Be vigilant for early signs of liver trouble, which can include unusual fatigue, pain in your upper right tummy, dark urine, or yellowing of the skin or eyes (jaundice). Report any such symptoms to your clinician immediately.
• Seek support for social situations: If you find it tricky to navigate social events without alcohol, consider using Medical Mojo’s health coaching service to develop alternative strategies.

3. Avoid certain pain relief medications and NSAIDs without medical guidance

While Low-Dose Naltrexone (LDN) doesn’t have a direct, dangerous interaction with common pain relievers like paracetamol or Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), it’s crucial to approach their combined use with caution and professional oversight. LDN is often prescribed for chronic inflammatory and autoimmune conditions that affect systems like the gut and liver. The frequent use of other medications that also stress these organs can create a cumulative burden, potentially leading to side effects or reducing the overall effectiveness of your treatment plan.

The concern is less about a direct clash and more about overlapping physiological stress. For instance, many people with fibromyalgia or long COVID rely on regular doses of pain relief to manage their symptoms. Adding daily NSAIDs to an LDN regimen could heighten the risk of stomach irritation or ulcers, as NSAIDs are known to affect the stomach lining [3]. Similarly, taking the maximum daily dose of paracetamol while on LDN could increase the strain on the liver, which is responsible for metabolising both substances. This is why a collaborative approach with your clinician is essential when considering what to avoid when taking low dose naltrexone.

Why it’s a problem and what to do

The primary issue is the potential for increased organ stress from long-term, combined use. For patients with conditions like Mast Cell Activation Syndrome (MCAS), who may be sensitive to various medication fillers and active ingredients, using over-the-counter combination products without guidance can lead to unforeseen reactions. The goal is to manage pain effectively without compromising your LDN therapy or your overall health.

A note on cumulative burden: Your liver and gastrointestinal system work hard to process everything you ingest. When you take multiple medications that affect these same organs—even if each is safe on its own—their combined effect can become problematic over time. This is especially relevant for chronic conditions requiring long-term management.

Practical tips for safe LDN use

To safely manage pain while on LDN, proactive communication and careful medication choices are key:

• Consult your pharmacist: Before taking any new over-the-counter pain medication, even for a simple headache, review it with your Medical Mojo pharmacist. They can check for hidden ingredients and advise on the safest option for you.
• Use the lowest effective dose: For any NSAID or paracetamol, always use the smallest dose that provides relief and for the shortest possible duration. This minimises potential strain on your body.
• Keep a medication diary: Keep a log of all medications and supplements you take, including doses and times. Share this log during your Medical Mojo follow-up calls to help your clinician spot potential issues.
• Consider topical alternatives: For localised pain, topical options like anti-inflammatory gels or patches can be a much safer alternative as they have minimal systemic absorption.
• Never exceed daily limits: It is absolutely vital to never exceed the recommended daily limit for paracetamol (typically four grams, or eight 500mg tablets, in 24 hours for an adult) to avoid the risk of serious liver damage.
• Explore different NSAIDs: If you need an NSAID, some may be gentler on the stomach than others. To understand the differences, you can compare options like naproxen vs ibuprofen with your clinician.

4. Avoid sudden discontinuation or dose changes without medical supervision

Low dose naltrexone (LDN) requires a consistent, stable dosing regimen to exert its therapeutic effects, particularly for autoimmune and inflammatory conditions where it supports immune system regulation. Suddenly stopping the medication or altering the dose without professional guidance is a critical mistake to avoid. The benefits of LDN are built on its steady, gentle influence on your body’s endorphin production; disrupting this balance can lead to a rapid return of symptoms or even a significant worsening of your underlying condition.

This is particularly important for patients managing complex, chronic conditions. For example, an individual with Multiple Sclerosis (MS) who abruptly stops LDN could experience a disease flare. Similarly, people with fibromyalgia have reported a significant rebound of pain and fatigue within a week or two of stopping without a taper. For those managing long COVID, sudden discontinuation can trigger a relapse of profound fatigue and cognitive dysfunction. The key is to view LDN not as a short-term fix but as a long-term regulator, where consistency is paramount.

Why it’s a problem and what to do

The primary issue with abruptly stopping LDN is the loss of its regulatory effect on the immune system and endorphin levels. This can cause the body to revert to its previous state of inflammation or immune dysregulation, leading to a swift and often severe return of symptoms. It is not a classic “withdrawal” in the addictive sense but a rebound of the condition LDN was successfully managing.

A note on symptom rebound: Unlike side effects that may occur when starting a medication, symptom rebound happens after stopping it. Your body had adapted to the therapeutic support from LDN, and its sudden removal can leave your system temporarily unable to manage inflammation on its own, leading to a flare-up that can be more intense than your baseline.

Practical tips for safe LDN use

To maintain therapeutic stability and avoid a symptom flare, follow these actionable steps:

• Never stop abruptly: The golden rule is to always consult your Medical Mojo clinician or pharmacist before making any changes. Even if you feel better or experience a side effect, do not stop taking it on your own.
• Plan for discontinuation: If you and your provider decide to stop LDN, a gradual tapering schedule is essential. This typically involves reducing the dose slowly, for instance by 0.5mg per week, to allow your body to adjust. This approach is similar to how other long-term medications are managed, as discussed in guides on Mounjaro dosing adjustments.
• Consistency is key: Take your LDN at the same time every day to maintain stable levels in your system and achieve the best therapeutic effect.
• Report all changes: Keep a log of your symptoms and discuss them during your free follow-up consultation calls. If you notice any new side effects, contact Medical Mojo immediately for guidance rather than stopping the medication independently.

5. Avoid use during active opioid withdrawal or dependence without specialist support

While low dose naltrexone works on the opioid system, it is fundamentally different from opioid medications. LDN is an opioid antagonist, meaning it blocks opioid receptors rather than activating them. This distinction is critical for anyone with a history of opioid dependence or who is currently using opioid medications, whether prescribed or not. Initiating LDN while opioids are still active in your system is one of the most dangerous things to avoid, as it can trigger a severe and abrupt medical crisis.

Introducing naltrexone into a system that is physically dependent on opioids causes a condition known as precipitated withdrawal  [1]. This isn’t a gradual decline into withdrawal symptoms; it’s a rapid, forceful eviction of all opioid molecules from their receptors. The resulting shock to the system can cause an intense and immediate onset of symptoms, creating a medical emergency that requires urgent care. This is why thorough screening, like that provided through Medical Mojo’s comprehensive online assessment, is a non-negotiable safety step.

Why it’s a problem and what to do

The core danger lies in naltrexone’s mechanism. By blocking opioid receptors, it instantly stops any opioids present in the body from working and throws the user into a state of acute withdrawal. This scenario is not just profoundly unpleasant; it can be medically dangerous due to severe symptoms like vomiting, diarrhoea, and extreme psychological distress.

A note on patient safety: The risk of precipitated withdrawal is so significant that a medically supervised “washout” period is essential. This means a patient must be completely free of all opioids—including long-acting ones like methadone—for a minimum of 7-10 days before LDN can be safely considered. For some longer-acting opioids, this period may need to be extended.

Practical tips for safe LDN use

To prevent this dangerous interaction, complete transparency and careful planning are paramount.

• Disclose your full history: Be completely honest about all opioid use, past and present, during your Medical Mojo online consultation. This includes prescribed painkillers, medications used for opioid use disorder like methadone, and non-prescribed substances. Your safety depends on it.
• Seek specialist coordination: If you have a history of opioid dependence, you must work with an addiction medicine specialist before considering LDN. They can manage a safe, medically supervised detoxification and determine the appropriate time to begin LDN therapy.
• Adhere to the washout period: Strictly follow the recommended opioid-free period of at least 7-10 days before your first dose. Your clinician may even recommend a urine screen to confirm that opioids are out of your system.
• Explore alternatives first: Use your Medical Mojo consultation to discuss non-opioid strategies for managing any underlying pain or other symptoms. This ensures you have support in place before making any changes.
• Utilise support services: If you are struggling with opioid dependence, your clinician can direct you to resources like NHS addiction services or private addiction medicine consultants who can provide the specialist support needed for a safe transition.

6. Avoid unmonitored use without baseline and regular liver function testing

Low dose naltrexone is generally considered safe, but it is metabolised by the liver. For this reason, one of the most important things to avoid is starting the treatment without proper medical oversight.

Baseline liver function tests (LFTs) aren’t routinely needed for everyone. They’re typically only recommended if you have pre-existing liver conditions like hepatitis or cirrhosis, take other medications that affect the liver, or have underlying inflammation that might impact liver enzymes.

However, follow-up LFTs can be arranged via Medical Mojo to track any changes over time and ensure your continued safety. This monitoring is a critical safety measure to catch any potential signs of hepatic stress before they become serious issues, and allows for prompt intervention — such as adjusting the dose or pausing treatment — if needed.

Symptoms to watch out for (possible liver irritation)

Be aware of the signs of liver dysfunction. Contact your clinician immediately if you notice:

• Yellowing of the skin or eyes (jaundice)
• Dark urine or unusually pale stools
• Pain or tenderness in the upper right side of your tummy
• Persistent nausea, vomiting, or loss of appetite
• Unusual itching
• Severe or unexplained fatigue or weakness that’s new for you

These symptoms warrant urgent attention, as they may indicate your liver needs a break from LDN or a dose adjustment.

Why it’s a problem and what to do

The primary issue is the potential for undetected liver strain. While LDN-induced liver issues are rare at low doses, your individual health profile, including other medications, alcohol use and underlying conditions, can increase the risk [2]. Without monitoring, changes in liver health could go unnoticed until symptoms like jaundice or abdominal pain appear, indicating a more advanced problem.

A note on cumulative risk: The liver processes everything you consume. If you are taking multiple medications or supplements, the cumulative burden on the liver can increase. Regular LFTs help your clinician assess this overall hepatic load and ensure your treatment plan remains safe and optimised for your body.

Practical tips for safe LDN use

To ensure your liver health is protected throughout your LDN journey, adopt these proactive measures:

• Establish a baseline if you have an existing liver condition: Before your first dose, get a baseline liver function test. Your GP can arrange this, and your Medical Mojo clinician can provide a template letter to help. Alternatively, you can order the at home liver function test from Medical Mojo. Review the results with your pharmacist before starting.
• Schedule follow-up tests: Plan for a follow-up LFT around 6-8 weeks after starting LDN. Subsequent tests are typically recommended every 3-6 months, depending on your baseline results and overall health profile.
• Disclose your full medical history: Be transparent about any history of liver disease, hepatitis, or heavy alcohol consumption during your online health assessment. This information is crucial for your clinician to assess your suitability for LDN.
• Recognise and report symptoms: Be aware of the signs of liver dysfunction, including yellowing of the skin or eyes (jaundice), dark urine, pale stools, upper-right abdominal pain, or persistent, unusual fatigue. Report any such symptoms to your clinician immediately.

7. Avoid taking LDN close to bedtime if you’re sensitive to it

One of the most common and often surprising side effects of low dose naltrexone (LDN) is its impact on sleep. While many people take their dose at night to align with the body’s natural endorphin peak, this timing can cause vivid dreams, insomnia, or disrupted sleep patterns in sensitive individuals [4]. Understanding your personal response to LDN is crucial, as inconsistent or poorly timed doses can compromise sleep quality—which is particularly unhelpful for those already managing sleep disorders, chronic fatigue, or long COVID.

The mechanism behind these sleep disturbances is linked to the brief opioid receptor blockade caused by LDN. This can temporarily alter the release of neurotransmitters that regulate sleep and wakefulness. For some, this stimulation is minor and fades quickly, but for others, it’s enough to interfere with falling or staying asleep. Because consistent receptor cycling is essential for LDN’s therapeutic effects, finding a dosing schedule that works for you without sacrificing sleep is key. For example, a patient with a pre-existing sleep disorder found that taking LDN at 9 PM worsened their insomnia, but shifting to a 7 AM dose resolved the issue while maintaining the medication’s benefits.

Why it’s a problem and what to do

The core issue is a conflict between LDN’s therapeutic action and an individual’s unique neurochemistry. Poor sleep doesn’t just make you feel tired; it can worsen pain, increase inflammation, and negate the very benefits you’re seeking from treatment. Ignoring timing sensitivity can lead to a cycle of fatigue and frustration, potentially causing you to abandon a treatment that could otherwise be highly effective.

A note on individual sensitivity: There is no one-size-fits-all answer for LDN timing. Some people thrive on evening doses, reporting deeper sleep and fewer side effects. Others find that only morning administration is tolerable. The key is to listen to your body and be prepared to adjust.

Practical tips for safe LDN use

To find your optimal dosing schedule and ensure LDN supports, rather than hinders, your well-being, follow these steps:

• Start with evening dosing and switch to morning dosing if needed: Begin by taking your LDN dose at night. If you experience difficulty falling asleep or any other sleep-related issues, switch to morning dosing. Then take the LDN early in the morning, between 6 AM and 8 AM. This strategy minimises the risk of sleep disruption from the outset.
• Maintain strict consistency: Take your dose at the same time every day. This consistency helps your body adapt and stabilises the therapeutic effect.
• Keep a sleep diary: For the first few weeks, track your sleep quality, noting when you take your LDN, how easily you fall asleep, and how you feel upon waking. This log provides valuable data for you and your clinician.
• Adjust, don’t abandon: If you experience sleep disturbances, try shifting your dose even earlier in the day before considering stopping the medication. A simple timing change is often all that’s needed.
• Combine with good sleep hygiene: Support your treatment by adopting evidence-based sleep practices. This includes maintaining a regular sleep schedule, creating a relaxing bedtime routine, and ensuring your bedroom is dark and quiet.
• Consult your pharmacist: Report any persistent sleep changes during your follow-up consultations. Your Medical Mojo pharmacist can help troubleshoot by suggesting a dose reduction or a different timing strategy. You can discover more about how LDN is tailored for you and the importance of personalised care.

A quick summary of what to avoid with low dose naltrexone

Thing to avoid	Why it matters	What to do instead
Opioid medications	Can cause severe, sudden withdrawal symptoms and block LDN’s effects.	Disclose all medications; plan non-opioid pain relief with your clinician.
Excessive alcohol	Strains the liver and can counteract the benefits of LDN.	Be honest about your intake; aim to abstain or limit alcohol significantly.
Unsupervised NSAIDs	Can lead to cumulative gut or liver stress when used long-term with LDN.	Consult your pharmacist before use; use the lowest effective dose for the shortest time.
Stopping suddenly	Can cause a rebound or flare-up of your condition’s symptoms.	Never stop without guidance; follow a gradual tapering plan with your clinician.
Use with opioid dependence	Extremely high risk of triggering a medical emergency (precipitated withdrawal).	Disclose all opioid history; work with a specialist for a safe washout period.
Unmonitored treatment	Risks of missing early signs of liver strain.	Get baseline and regular liver function tests as advised by your clinician.
Ignoring timing sensitivity	A nighttime dose can cause insomnia or vivid dreams for some people.	Start with a morning dose; keep a sleep diary and adjust timing if needed.

Navigating your LDN journey with confidence

Stepping into the world of low dose naltrexone can feel like a big moment in your health journey, especially when you’re managing complex conditions like chronic pain or autoimmune disorders. The path to finding balance and relief is often paved with careful choices and a deep understanding of how to support your body. This guide has aimed to demystify the process by highlighting exactly what to avoid when taking low dose naltrexone, turning potential pitfalls into opportunities for proactive self-care.

By now, you’ll recognise that successfully using LDN isn’t just about remembering to take a pill. It’s an active, engaged process that involves a mindful partnership between you and your healthcare team. It’s about building a robust framework of awareness around your lifestyle, medications, and bodily responses to ensure LDN can do its job effectively and safely.

Your essential LDN checklist: key takeaways

Let’s distil the core principles we have explored into a simple, actionable checklist. Think of these points as your foundational pillars for a successful LDN experience:

• Opioid awareness is non-negotiable: The absolute priority is avoiding all opioid-containing medications and even certain herbal supplements. This interaction is the most critical to prevent.
• Communicate before you medicate: Before taking any new medication—especially for pain relief like NSAIDs—a quick consultation with your prescribing clinician or pharmacist is vital.
• Consistency is your ally: Abruptly stopping LDN or making drastic dose changes on your own can disrupt the therapeutic progress you’ve made. Always follow a structured, medically supervised plan.
• Monitor and partner with your clinician: Regular check-ins and recommended tests, such as liver function monitoring, are essential safety measures that allow for personalised and effective care.

Mastering these principles for long-term success

Understanding and applying these strategies does more than just prevent negative side effects; it empowers you to take control of your treatment. When you know what to avoid, you can navigate everyday situations with confidence rather than anxiety. This knowledge allows you to advocate for yourself effectively and make informed daily choices that support your overall well-being.

The real power of LDN is unlocked when it is integrated into a holistic, well-managed health strategy. Avoiding these key pitfalls ensures that LDN can work as intended, helping to modulate your immune system and reduce inflammation without interference.

Your journey with LDN is a testament to your commitment to finding innovative solutions for your health. Each step you take, guided by this knowledge, reinforces your role as the central figure in your own care team. Remember, the team at Medical Mojo is here to be your co-pilot. Our specialist pharmacists and health coaches are dedicated to providing the personalised support and expert guidance you need to navigate this path. Whether you have a question about a potential interaction or need help fine-tuning your routine, we are here to help you thrive.

How this content was created:

This article was written by a qualified health writer and reviewed for clinical accuracy by a registered pharmacist. The information is based on current evidence and best practices in the use of low-dose naltrexone. Patient experiences have been included to provide real-world context and support.

Disclaimer: This article is for informational purposes only and is not a substitute for professional medical advice. Always speak to a qualified clinician or pharmacist before starting, stopping, or changing treatment.

References

[1] National Center for Biotechnology Information (2024). Naltrexone. PubChem Compound Summary for CID 5360515. Available at: https://pubchem.ncbi.nlm.nih.gov/compound/Naltrexone

[2] NHS (2022). Naltrexone hydrochloride. Available at: Alcohol misuse – Treatment – NHS 

[3] NICE (2024). Non-steroidal anti-inflammatory drugs (NSAIDs). National Institute for Health and Care Excellence. Available at: https://www.nice.org.uk/guidance/ng193/chapter/Recommendations#non-steroidal-anti-inflammatory-drugs-nsaids 

[4]. LDN Effects on sleep. Available at : What Are the Side Effects of Low Dose Naltrexone? – Biology Insights