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Low Dose Naltrexone 4.5mg capsules

from£39.99

Low Dose Naltrexone 4.5mg Capsules are designed to modulate the immune system and reduce inflammation, commonly used as an off-label treatment for various autoimmune and chronic pain conditions. Taken once daily, this low-dose formulation offers potential benefits for conditions like multiple sclerosis, fibromyalgia, and Crohn’s disease, helping to improve overall symptom management.

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Low Dose Naltrexone 4.5mg capsules
SKU: LDN4.5CPS Category: Tags: , ,

Description

Product Information: Low Dose Naltrexone 4.5mg Capsules

Description:

Low Dose Naltrexone (LDN) 4.5mg capsules are a lower-dose formulation of naltrexone, an opioid receptor antagonist. While standard doses of naltrexone are typically used to treat opioid and alcohol dependence, LDN is used in much smaller doses to modulate the immune system and alleviate symptoms of various chronic conditions.

Uses:

Low Dose Naltrexone 4.5mg capsules are commonly used as an off-label treatment for conditions such as:

  • Autoimmune diseases (e.g., multiple sclerosis, lupus, rheumatoid arthritis)
  • Chronic pain disorders (e.g., fibromyalgia, complex regional pain syndrome)
  • Inflammatory bowel diseases (e.g., Crohn’s disease, ulcerative colitis)
  • Certain cancers, as an adjunct to traditional cancer treatments
  • Other conditions involving chronic inflammation or immune dysfunction

How It Works:

LDN works by temporarily blocking opioid receptors in the body, which is believed to increase the production of endorphins and modulate the immune response. This can lead to reduced inflammation and pain, as well as an improved immune system balance.

Dosage:

The typical dosage for Low Dose Naltrexone is 4.5mg taken once daily, usually at bedtime. However, the dose may vary depending on the condition being treated and the individual’s response to the medication. It is essential to follow the prescribing healthcare provider’s instructions.

Side Effects:

Common side effects of LDN include:

  • Sleep disturbances (e.g., vivid dreams or insomnia)
  • Gastrointestinal issues (e.g., nausea or upset stomach)
  • Mild headaches

Most side effects are temporary and tend to resolve as the body adjusts to the medication. If side effects persist or worsen, consult a healthcare provider.

Precautions:

  • LDN is not recommended for use in individuals who are currently using opioid medications, as it may block the effects of these drugs.
  • Patients should inform their healthcare provider of any other medications or supplements they are taking to avoid potential interactions.
  • Pregnant or breastfeeding women should consult their healthcare provider before starting LDN.

Storage:

Store the capsules in a cool, dry place away from direct sunlight and moisture. Keep out of reach of children.

Consultation:

Always consult with a healthcare provider before starting or adjusting the dosage of Low Dose Naltrexone to ensure it is appropriate for your specific condition and health needs.

Additional information

Quantity

1x 30, 2 x 30, 3 x 30

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Overview

Active ingredients

What is it for?

How does it work?

How do you use it?

Warnings and precautions

Side effects

Drug interactions

FAQs

Download patent leaflet

Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Superintendant Pharmacist, Independent Prescriber


Checked By
Dr Sarah Thornton
MbChB, Coaching Academy diploma with distinction

GP, Medical coach


What are Low Dose Naltrexone (LDN) 4.5mg capsules?

Low Dose Naltrexone (LDN) 4.5mg capsules are exactly what it says it is, a low dose of naltrexone. Usually, licensed naltrexone tablets are available strengths of 50mg, but low-dose naltrexone is specially compounded to deliver lower doses of around 4.5mg.

The higher doses of 50mg are used to treat addiction but for conditions such as fibromyalgia doses between 1 to 4.5mg are generally used. Naltrexone is traditionally prescribed to block the effects of opioids, but at low doses (typically 1.5 to 4.5 mg), it is believed to modulate the immune system and reduce inflammation.

Low Dose Naltrexone (LDN) 4.5mg capsules are a lower-dose formulation of naltrexone, a medication originally used to treat opioid and alcohol dependence. In low doses, naltrexone is believed to help regulate the immune system and reduce inflammation, making it a potential treatment option for various autoimmune and chronic pain conditions, such as multiple sclerosis, fibromyalgia, and Crohn’s disease. LDN is typically taken once daily and is used off-label for these purposes, meaning it is not yet FDA-approved specifically for these conditions.

What is the active ingredient in Low Dose Naltrexone (LDN) 4.5mg capsules?

The active ingredient in the lo dose naltrexone capsules is naltrexone hydrochloride 4.5mg.

What are the Low Dose Naltrexone (LDN) 4.5mg capsules used for?

Low Dose Naltrexone (LDN) 4.5mg capsules are used off-label to manage a variety of chronic and inflammatory conditions. Some of the common uses include:

  1. Autoimmune Diseases: LDN is often used to help manage conditions like multiple sclerosis (MS), rheumatoid arthritis, lupus, and Hashimoto's thyroiditis by modulating the immune system and reducing inflammation.
  2. Chronic Pain Disorders: It is used in the treatment of chronic pain conditions such as fibromyalgia and complex regional pain syndrome (CRPS), where it may help reduce pain and improve quality of life.
  3. Inflammatory Bowel Diseases: LDN has shown promise in managing symptoms of Crohn's disease and ulcerative colitis by reducing gut inflammation.
  4. Cancer: Some patients use LDN as an adjunctive therapy in cancer treatment to enhance the immune system and potentially improve outcomes, although more research is needed in this area.
  5. Neurological Disorders: LDN is also used in conditions like Parkinson’s disease and Alzheimer’s disease to potentially slow disease progression and improve symptoms, though evidence is still emerging.
  6. Irritable Bowel Syndrome (IBS): It can help alleviate symptoms of IBS, such as abdominal pain and irregular bowel movements, by reducing intestinal inflammation.

LDN is generally well-tolerated, but it is important to consult a healthcare provider to determine if it is appropriate for your condition.

How does the Low Dose Naltrexone (LDN) 4.5mg capsules work?

Low Dose Naltrexone (LDN) 4.5mg capsules work differently from the standard 50mg dose used for treating opioid addiction. At the higher dose, naltrexone fully blocks opioid receptors, preventing the euphoric effects of opioids and aiding in addiction treatment. However, when taken in much lower doses, between 0.1mg and 6mg, naltrexone only partially blocks these receptors. This partial blockade signals the body to increase its production of endorphins—natural painkillers—which can enhance pain relief and help regulate the immune system.

How LDN Works

  • Endorphin Boost: The slight blocking of opioid receptors with LDN leads to an increase in endorphin production. These endorphins not only relieve pain but also play a critical role in balancing the immune system, which can be beneficial for conditions where the immune system is overactive or misregulated.
  • Immune System Regulation: By increasing endorphins, LDN helps modulate the immune response, which can be helpful in autoimmune diseases, chronic inflammation, and even some cancers. Endorphins help regulate cell growth, potentially inhibiting the growth of cancer cells.

Role of Toll-Like Receptors (TLRs)

  • TLRs and Inflammation: TLRs are proteins that play a key role in the immune system's first response to invaders like bacteria and viruses. When these receptors are over-activated, they can cause excessive inflammation, which is harmful in conditions like chronic pain or autoimmune diseases.
  • LDN and TLR4: LDN, particularly its "dextro" form, can block TLR4, reducing unnecessary inflammation. This action helps to calm the immune system and can alleviate symptoms of neuropathic pain, making LDN useful for conditions involving chronic pain and inflammation.

Additional Benefits

  • Chiral Nature: Naltrexone exists in two forms—levo-naltrexone and dextro-naltrexone. Levo-naltrexone boosts endorphin production by blocking opioid receptors, while dextro-naltrexone blocks TLRs, reducing inflammation and potentially aiding in cancer treatment.
  • Pain Relief and Inflammation Control: LDN’s combined effects on opioid receptors and TLRs make it a powerful tool for managing pain, reducing inflammation, and supporting immune system balance.

In summary, LDN 4.5mg capsules provide a unique approach to pain management and immune modulation, offering benefits for a range of conditions from chronic pain to autoimmune diseases, thanks to its dual action on opioid receptors and TLRs.

How do you use Low Dose Naltrexone (LDN) 4.5mg capsules?

To use Low Dose Naltrexone (LDN) 4.5mg capsules, follow these general guidelines:

  • Dosage: Take one 4.5mg capsule daily, preferably at bedtime. The timing helps to align with the body's natural rhythms and optimise endorphin production.
  • Consistency: Take the capsule at the same time each day to maintain steady levels in the body.
  • With or Without Food: LDN can be taken with or without food, but maintaining a consistent routine can help with adherence.
  • Swallowing: Swallow the capsule whole with water. Do not crush or chew the capsule.
  • Alternative Timing: If taking LDN at night disturbs your sleep, you can switch to taking it in the morning, as advised by your healthcare provider.

Always follow the specific instructions provided by your healthcare provider, who may adjust the dose or timing based on your individual needs and condition.

Who should not use Low Dose Naltrexone (LDN)?

Avoid taking opiates while using low-dose naltrexone 4.5mg capsules. Although this medication generally blocks some of the effects of opiates (such as the euphoric "high"), taking high doses of opiates can still lead to severe breathing difficulties and circulatory problems, which could result in opiate poisoning.

  • Do not use low-dose naltrexone 4.5mg capsules if you are still dependent on opiates, as it can trigger severe withdrawal symptoms.
  • Be sure to inform every healthcare provider that you are using low-dose naltrexone 4.5mg capsules If you require anesthesia in an emergency, non-opiate-based anesthetics should be used. If opiate-containing anesthetics are necessary, higher doses may be required, and you may be more susceptible to side effects such as breathing difficulties and circulatory issues.
  • Do not attempt to counteract the blocking effects of low-dose naltrexone 4.5mg capsules by taking high doses of opiates. There is a risk that opiates could remain in your system after the effects of naltrexone have worn off, potentially leading to an unintentional overdose with serious consequences.
  • Low-dose naltrexone 4.5mg capsules are metabolised by the liver and kidneys. Since liver problems are common in individuals with opiate dependence, your doctor will perform liver function tests before and during treatment.

Other Medicines and Low-Dose Naltrexone 4.5mg capsules:

Inform your doctor if you are taking, have recently taken, or might take any other medications, including those obtained without a prescription. Some common medications contain opiates and may not be effective while you are using low-dose naltrexone 4.5mg capsules.

If you need cough syrups, medications for diarrhea, or pain relievers, inform your doctor, as these may contain opiates. In emergency cases where opioid-containing drugs are required, the necessary dose for pain relief may be higher than usual. Close medical supervision is essential, as respiratory depression and other symptoms may be more intense and prolonged.

Pregnancy and Breastfeeding:

If you are pregnant, breastfeeding, think you may be pregnant or are planning to have a baby, consult your doctor or pharmacist before taking this medication. Low-dose naltrexone 4.5mg capsules should only be used during pregnancy if the potential benefit to the mother outweighs the possible risks. Breastfeeding is not recommended while taking this medication. Always consult your doctor for advice.

Driving and Using Machines:

Low-dose naltrexone 4.5mg capsules may cause drowsiness or reduce alertness. Do not drive or operate machinery if you experience these effects.

What are the side effects of Low Dose Naltrexone (LDN) 4.5mg capsules?

The side effects of Low Dose Naltrexone (LDN) 4.5mg capsules are generally mild but can include:

  • Sleep Disturbances: Some people may experience vivid dreams or insomnia.
  • Digestive Issues: Nausea, constipation, or diarrhea can occur, especially when starting treatment.
  • Fatigue: Feeling unusually tired or drowsy.
  • Headaches: Mild to moderate headaches are possible.
  • Mood Changes: Some individuals may experience mood swings or feelings of euphoria.
  • Joint or Muscle Pain: Achiness or discomfort in muscles or joints.

These side effects are usually temporary and may diminish as the body adjusts to the medication. If side effects persist or worsen, it's important to consult your healthcare provider.

Does Low Dose Naltrexone (LDN) 4.5mg capsules interact with other medicines?

Inform your doctor if you are currently taking, have recently taken, or plan to take any other medications, including those available over the counter. Some common medications contain opiates and may not work effectively while you are using low-dose naltrexone.

If you require cough syrups, diarrhea medications, or pain relievers, let your doctor know, as these might contain opiates. In emergency situations where opioid-containing drugs are necessary, higher doses may be required for effective pain relief. Close medical supervision is crucial, as there is an increased risk of respiratory depression and other prolonged or intensified side effects.

Low Dose Naltrexone (LDN)4.5mg capsules FAQs

What is Low Dose Naltrexone (LDN)?

Low Dose Naltrexone (LDN) is a medication used in small doses (usually between 0.5mg and 4.5mg) to help manage various conditions, including autoimmune diseases, chronic pain, and some neurological conditions. It works by boosting the body's production of endorphins and modulating the immune system.

How does LDN work?

LDN works by temporarily blocking opioid receptors in the brain, which stimulates the production of endorphins, the body's natural painkillers. It also affects immune function by modulating inflammation and regulating immune responses.

What conditions can LDN help treat?

LDN is commonly used to manage conditions such as fibromyalgia, multiple sclerosis, Crohn’s disease, rheumatoid arthritis, lupus, and even certain cancers. It is also used for chronic pain management and as a complementary treatment for conditions related to immune system dysfunction.

How do I take Low Dose Naltrexone (LDN) 4.5mg capsules?

LDN is typically taken once daily, usually at night before bedtime. If sleep disturbances occur, it may be taken in the morning. Always follow your healthcare provider's instructions regarding dosage and timing.

What are the common side effects of LDN?

Some common side effects of LDN may include sleep disturbances (like vivid dreams or insomnia), nausea, digestive issues (constipation or diarrhea), headaches, fatigue, and mild mood changes. These effects usually subside after a few days to weeks.

Can LDN be taken with other medications?

LDN can generally be taken alongside other medications, but it’s important to inform your healthcare provider about any current medications to avoid potential interactions, especially with other immune-modulating drugs or painkillers.

Is LDN safe to use for long-term treatment?

LDN is generally considered safe for long-term use. However, it’s important to regularly check in with your healthcare provider to monitor for any changes in your condition or side effects, particularly when used for managing chronic conditions.

Can I take LDN if I’m pregnant or breastfeeding?

It’s best to avoid using LDN during pregnancy or while breastfeeding unless advised by a healthcare provider. There is limited information on its safety in these situations, so a discussion with a doctor is crucial.

Will LDN cause any withdrawal symptoms?

Since LDN is used at much lower doses than the typical naltrexone treatment for addiction, it is unlikely to cause withdrawal symptoms. However, sudden discontinuation should be done under medical supervision to ensure safety.

How long does it take for LDN to start working?

Some people may experience benefits from LDN within a few days, while for others, it may take several weeks to notice improvements in symptoms. Patience is required, as it can take time for the body to adjust and for the full effects of LDN to become noticeable.

Download patient leaflet

low dose naltrexone 4.5mg capsules medicalmojo.co.uk

Checked By
Dr Sarah Thornton
MbChB, Coaching Academy diploma with distinction

GP, Medical coach


Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Superintendant Pharmacist, Independent Prescriber


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