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Chlorpheniramine 2mg/ml syrup

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Chlorphenamine is a sedating antihistamine used to relieve symptoms of allergies such as hay fever, pet allergies, and skin reactions. Available in both tablet and oral solution forms, it effectively reduces itching, sneezing, runny nose, and other allergic reactions by blocking histamine in the body. Suitable for adults and children over 6 years old (tablets) and over 1 year old (oral solution), Chlorphenamine is a versatile treatment for a wide range of allergic conditions. Its sedative properties can also help promote restful sleep, making it an ideal choice for nighttime allergy relief.

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Chlorpheniramine 2mg/ml syrup

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1 x 150ml, 2 x 150ml, 3 x 150ml

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Overview

Active ingredients

What is it for?

How does it work?

How do you use it?

Warnings and precautions

Side effects

Drug interactions

FAQs

Download patent leaflet

Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Independent prescriber, Superintendent pharmacist.


Checked By
Dr Sarah Thornton
MbChB, Coaching Academy diploma with distinction

Medical coaching


What is Chlorpheniramine?

Chlorphenamine is part of a class of medications known as antihistamines. When the body encounters an allergen, it releases chemicals like histamine, which are responsible for triggering the symptoms of an allergic reaction, such as itching, swelling, and redness. Chlorphenamine works by blocking the action of histamine at its receptors, thereby preventing or reducing these allergic symptoms. By inhibiting histamine’s effects, chlorphenamine helps to alleviate discomfort and manage allergic responses effectively, making it a widely used treatment for conditions like hay fever, allergic rhinitis, and other allergic reactions.

What is the active ingredient in chlorpheniramine?

The active ingredient is the antihistamine, chlorpheniramine.

What is chlorpheniramine used for?

Chlorphenamine is effective in treating symptoms related to various allergic conditions, including:
  • Hay fever
  • Nettle rash (urticaria)
  • Food allergies
  • Allergic reactions to insect bites
  • Allergic reactions to certain medications
  • Itching associated with chickenpox
 

How does chlorpheniramine work?

Chlorpheniramine works by blocking the action of histamine, a natural chemical in the body that is released during an allergic reaction. Histamine binds to its receptors, causing symptoms like itching, swelling, redness, and increased mucus production. Chlorpheniramine, as an antihistamine, prevents histamine from binding to its receptors, thereby reducing or eliminating these allergic symptoms. This helps alleviate the discomfort associated with allergies, such as sneezing, runny nose, itching, and hives.  

How do you take chlorpheniramine tablets?

Ensure the seal is intact before first use. If it's broken, do not administer the medicine. Always use the provided syringe for accurate dosing. The syringe can measure either 2.5 ml or 5 ml by drawing the liquid to the appropriate mark. Administer this medicine by mouth as follows:
  • Age: Dosage: Frequency
  • Children 1-2 years: 2.5 ml, Up to 2 times in 24 hours, if needed
  • Children 2-6 years: 2.5 ml, Up to 6 times in 24 hours, if needed
  • Children 6-12 years: 5 ml, Up to 6 times in 24 hours, if needed
  • Children 12 years and over, and adults: 10 ml, Up to 6 times in 24 hours, if needed
  • Elderly: 10 ml, Up to 3 times in 24 hours, if needed
Important Notes:
  • Do not administer doses more frequently than every 4 to 6 hours.
  • For the elderly: Consult your doctor or pharmacist before using this syrup, as you may be more prone to side effects, including confusion, and may require a lower daily dose.
  • Not suitable for children under 1 year.
  • Do not exceed the recommended dosage.
  • If symptoms persist for more than 5 days, consult your pharmacist or doctor.

Who should not take chlorpheniramine?

If you answer YES to any of the following questions, DO NOT take this medicine without consulting your doctor:
  • Have you ever had an allergic reaction to a medicine containing chlorphenamine or any of the other ingredients in this medicine, please refer to the patient information leaflet?
  • Have you taken a Monoamine Oxidase Inhibitor (MAOI) to treat depression within the last 14 days?
Warnings and Precautions Before taking chlorphenamine tablets, speak with your doctor, pharmacist, or nurse if any of the following apply to you:
  • Very high blood pressure
  • Epilepsy
  • Heart disease, liver disease, or kidney disease
  • Glaucoma
  • Enlarged prostate
  • Bronchitis, asthma, or bronchiectasis
If you are taking other medicines containing antihistamines, including products for cold and cough relief, talk to your doctor before taking this medicine. Special Considerations for Other Patient Groups
  • Children and the elderly are more prone to the neurological and anticholinergic effects of chlorphenamine.
  • This medicine is NOT suitable for children under 6 years of age.
Other Medicines and Chlorphenamine Tablets Inform your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, particularly the following:
  • Medicines with a sedative effect (e.g., drugs for sleep problems or anxiety) as they may increase the sedative effects of chlorphenamine, such as Monoamine Oxidase Inhibitors (MAOIs).
  • Phenytoin (a medicine used to treat epilepsy), as its effects may be increased when taken with chlorphenamine.
Pregnancy and Breast-feeding If you are pregnant, breastfeeding, think you might be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. Warnings:
  • Do not drive or operate machinery if the tablets make you feel drowsy, dizzy, or if you experience blurred vision.
  • Avoid drinking alcohol while taking this medicine.
Chlorphenamine Tablets Contain Lactose If your doctor has informed you that you have an intolerance to certain sugars, consult them before taking this medicine. Chlorphenamine Tablets Contain Sunset Yellow (E110) Sunset Yellow (E110) in these tablets may cause allergic reactions in some individuals.

What are the side effects of Chlorpheniramine?

Like all medicines, this medication can cause side effects, although not everyone experiences them. Children and older adults may be more susceptible to side effects.
  • Common Side Effect: The most common side effect is drowsiness, which can be beneficial if symptoms are particularly bothersome at night.
Stop taking this medicine and consult your doctor immediately if you:
  • Experience an allergic reaction, which can be severe. Signs include raised, itchy skin, swelling of the face or mouth, and difficulty breathing.
  • Develop liver problems.
  • Experience anemia, unexplained bleeding, or bruising.
  • Have difficulty passing urine.
  • Experience fainting or collapse.
Other side effects may include:
  • Difficulty concentrating, feeling tired, dizziness, headache, or blurred vision.
  • Loss of appetite, indigestion, nausea, vomiting, diarrhea, stomach pain, or dry mouth.
  • Low blood pressure (which may cause fainting) or changes in heart rhythm.
  • Chest tightness or thickening of the phlegm.
  • Skin reactions such as peeling, itchy rash, and increased sensitivity to the sun.
  • Ringing in the ears.
  • Muscle-related symptoms including twitching, muscular weakness, and abnormal coordination.
  • Mental and emotional changes such as confusion, excitability, irritability, low mood, or nightmares.
  • Children may experience increased excitability.
  • Reporting side effects: If you experience any side effects, speak with your doctor, pharmacist, or nurse. This includes any side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at yellowcard.mhra.gov.uk. Reporting side effects helps to gather more information on the safety of this medicine.
 

Do any other medicines interact with Chlorpheniramine?

Chlorphenamine should not be used if you have taken any monoamine oxidase inhibitors (MAOIs) in the last 14 days. MAOIs are a type of antidepressant, and examples include:
  • Phenelzine
  • Tranylcypromine
  • Isocarboxazid
Using Chlorphenamine in conjunction with antimuscarinic medicines may increase the risk of experiencing certain side effects, such as dry mouth, blurred vision, and constipation. These medicines include:
  • Antimuscarinic medications for Parkinson’s symptoms, such as procyclidine, orphenadrine, and trihexyphenidyl
  • Antimuscarinic medicines for urinary incontinence, such as oxybutynin, flavoxate, tolterodine, propiverine, and trospium
  • Some antipsychotics, such as chlorpromazine and clozapine
  • Antispasmodics, such as hyoscine and atropine
  • Tricyclic antidepressants, such as amitriptyline and imipramine

Chlorpheniramine FAQs

What is Chlorphenamine and what is it used for?

Chlorphenamine is an antihistamine medication available in tablet and oral solution forms. It contains chlorphenamine maleate, a sedating antihistamine that helps prevent the actions of histamine in your body. Chlorphenamine is commonly used to treat symptoms of allergic conditions such as:
  • Hay fever
  • Nettle rash (urticaria)
  • Food allergies
  • Allergic reactions to insect bites
  • Allergic reactions to certain medications
  • Itching caused by chickenpox
Chlorphenamine is available as 4mg tablets, suitable for adults and children over 6 years, and as a 2mg/5ml oral solution, suitable for children over 1 year.

How does Chlorphenamine work?

Chlorphenamine works by blocking histamine receptors in the body, reducing the effects of histamine, which is released during an allergic reaction. By preventing histamine from causing symptoms such as sneezing, itching, a runny nose, and redness, Chlorphenamine helps to alleviate allergic reactions. It is considered a sedating antihistamine because it can cross into the brain, often causing drowsiness.

What are the alternatives to Chlorphenamine?

Chlorphenamine can be used alone or with other treatments like eye drops (Opticrom) or nasal sprays (Pirinase, Benacort, Beclometasone) to treat localized allergy symptoms. Painkillers like ibuprofen or paracetamol can also be used alongside Chlorphenamine if you experience pain or inflammation. Other non-prescription oral antihistamines include:
  • Cetirizine (non-drowsy)
  • Loratadine (non-drowsy)
  • Piriton (sedating)

Can Chlorphenamine affect allergy tests?

Yes, if you plan to undergo allergy testing, you should stop taking Chlorphenamine at least 2 days before the tests. Chlorphenamine can treat allergy symptoms, which may interfere with the results of the tests.

Can I take Chlorphenamine with other medications?

Chlorphenamine should not be used if you have taken monoamine oxidase inhibitors (MAOIs) within the last 14 days. These are a type of antidepressant, including:
  • Phenelzine
  • Tranylcypromine
  • Isocarboxazid
The risk of side effects like dry mouth, blurred vision, and constipation can increase when Chlorphenamine is used alongside certain antimuscarinic medications or other drugs.

Can I drive while taking Chlorphenamine?

Chlorphenamine can cause drowsiness, so if you experience this side effect, you should avoid driving or operating machinery.

Should I avoid alcohol while taking Chlorphenamine?

Yes, you should avoid alcohol while taking Chlorphenamine, as it can increase the likelihood of drowsiness and other unwanted side effects.

How should I take Chlorphenamine?

  • Adults and children over 12 years: Take 1 tablet (4mg) or 10ml of oral solution every 4-6 hours, with a maximum of 6 doses in 24 hours. Elderly adults should limit themselves to no more than 3 tablets per day to reduce the risk of side effects.
  • Children 6-12 years: Take half a tablet or 5ml of oral solution every 4-6 hours, with a maximum of 3 doses in 24 hours.
  • Children 2-6 years: Take 2.5ml of oral solution every 4-6 hours, with a maximum of 6 doses in 24 hours.
  • Children 1-2 years: Take 2.5ml of oral solution twice daily, with a maximum of 2 doses in 24 hours.
If symptoms persist, consult your doctor or pharmacist.

What are the ingredients in Chlorphenamine?

  • Tablets: Each tablet contains 4mg of chlorphenamine maleate and inactive ingredients like lactose, maize starch, and magnesium stearate.
  • Oral Solution: Each 5ml contains 2mg of chlorphenamine maleate, with inactive ingredients such as sucrose, glycerol, ethanol, peppermint oil, and various preservatives.

What are the side effects of Chlorphenamine?

Common side effects include:
  • Drowsiness
  • Dizziness
  • Headaches
  • Blurred vision
  • Feeling sick
  • Loss of appetite
If you experience severe side effects such as swelling of the face or difficulty breathing, seek immediate medical attention. If you have concerns about side effects, consult a pharmacist or doctor.

Download patient leaflet

https://www.medicines.org.uk/emc/files/pil.3928.pdf

Checked By
Dr Sarah Thornton
MbChB, Coaching Academy diploma with distinction

Medical coaching


Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Independent prescriber, Superintendent pharmacist.


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