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Differin 0.1% Gel

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Differin is a prescription-only topical medication primarily used to treat acne. It contains the active ingredient adapalene, a type of retinoid that helps to reduce inflammation and promote the turnover of skin cells. By preventing the formation of new acne lesions and helping to clear existing ones, Differin works to improve the overall texture and clarity of the skin. It is typically applied once daily to the affected areas, and it’s suitable for use in both adults and adolescents aged 12 years and older. Differin is known for being effective yet gentle on the skin, making it a popular choice for long-term acne management.

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Differin 0.1% Gel
SKU: DIFCGEL Category: Tags: ,

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1 x 45g, 2 x 45g, 3 x 45g

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Overview

Active ingredients

What is it for?

How does it work?

How do you use it?

Warnings and precautions

Side effects

Drug interactions

FAQs

Download patent leaflet

Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Independent prescriber, Superintendent pharmacist.


Checked By
Dr Sarah Thornton
MbChB, Coaching Academy diploma with distinction

Medical coaching


What is Differin?

Differin is a topical medication used to treat acne. It contains adapalene, a type of retinoid, which is a derivative of vitamin A. Differin works by promoting the turnover of skin cells, preventing pores from becoming clogged, and reducing inflammation. This action helps to treat existing acne and prevent new breakouts from forming. It is typically applied once daily to the affected areas and is suitable for use in both adults and adolescents aged 12 years and older. Differin is available in various forms, including gel and cream, and is often recommended for long-term acne treatment.

What is the active ingredient in Differin?

Differin contains the active ingredient: adapalene 0.1%.

What is Differin used for?

Differin is primarily used to treat acne. It is effective in managing mild to moderate acne, which typically includes the presence of blackheads, whiteheads, and inflamed pimples on the face, chest, or back. Differin works by unclogging pores, reducing inflammation, and promoting the renewal of skin cells. It helps to prevent new acne from forming while treating existing blemishes, leading to clearer skin over time.

How does Differin work?

Differin contains the active ingredient adapalene, which is a type of retinoid. Adapalene works by targeting the processes in the skin that cause acne. Here’s how Differin works:
  1. Regulates Skin Cell Turnover: Differin helps to normalize the shedding of dead skin cells inside the pores, preventing them from becoming clogged. This reduces the formation of comedones, which are the blocked pores that can lead to blackheads and whiteheads.
  2. Reduces Inflammation: Adapalene has anti-inflammatory properties, which help to reduce the redness and swelling associated with acne. This makes it effective not only in treating existing acne but also in preventing new pimples from forming.
  3. Prevents New Acne: By keeping the pores clear and reducing inflammation, Differin helps to prevent the formation of new acne lesions.
Overall, Differin promotes a smoother skin texture, reduces the frequency of acne breakouts, and helps to improve the overall appearance of the skin.

How do you use Differin?

Always use Differin exactly as directed by your doctor. If you are unsure, consult your doctor or pharmacist for guidance.
  • Intended Use: Differin is for external use only and is suitable for adults and adolescents aged 12 years and over.
  • Application Time: Apply Differin at night before bed, unless instructed otherwise by your doctor.
  • Preparation: Wash the affected areas with water, ensuring the skin is clean and dry before applying the medicine.
  • Application: Apply a thin layer of Differin cream with your fingertips to the affected areas and gently rub it in. Be sure to wash your hands afterward.
  • Duration of Use: The length of treatment depends on how quickly your acne improves. After 3 months of use, it's important to see your doctor to evaluate your progress.
What to Do in Case of Overuse or Accidental Ingestion:
  • Applying too much Differin will not clear your acne faster but may cause skin irritation, redness, peeling, or discomfort. If you accidentally swallow any, seek medical advice.
Missed Dose:
  • If you forget to apply Differin, don't worry. Simply apply it when you remember and continue with your regular routine. If you have further questions, consult your doctor or pharmacist.

 Who should not use Differin?

  • Pregnancy: Do not use Differin if you are pregnant or planning to become pregnant.
  • Allergies: Avoid using Differin if you are allergic to adapalene or any other ingredients in the medication, please refer to patient information leaflet.

Warnings and Precautions:

  • Skin Conditions: Do not apply Differin to areas with cuts, scrapes, sunburn, or on skin with eczema.
  • Sensitive Areas: Avoid contact with the eyes, mouth, corners of the nose, and other sensitive areas. If contact occurs, rinse immediately with warm water.
  • Sunlight and UV Exposure: Minimize exposure to strong sunlight and artificial UV light. It is recommended to use sunscreen and protective clothing on treated areas.
  • Skin Irritation: If you experience sensitivity or irritation, discontinue use and consult your doctor. You may be advised to reduce application frequency or pause treatment until symptoms subside.

Pregnancy, Breastfeeding, and Fertility:

  • Pregnancy: Do not use Differin if you are pregnant or planning to become pregnant. If you become pregnant while using Differin, stop the treatment and inform your doctor immediately.
  • Breastfeeding: Differin can be used during breastfeeding, but avoid applying it to the chest area to prevent exposure to the infant.

Ingredients to Note:

  • Allergens: Differin contains methyl parahydroxybenzoate (E218) and propyl parahydroxybenzoate (E216), which may cause allergic reactions, possibly delayed.

What are the side effects with Differin?

Like all medicines, Differin Cream can cause side effects, although not everyone will experience them. Side effects typically occur at the application site. Seek immediate medical attention if you notice any of the following symptoms, as they may indicate a serious allergic reaction (angioedema) or a severe allergic response:
  • Swelling of the face, lips, or throat, which may cause difficulty swallowing or breathing
  • Rash, itching, hives
  • Dizziness
These symptoms are rare, and the exact frequency is not known.

Common Side Effects (may affect up to 1 in 10 people):

  • Dry skin
  • Skin irritation
  • Burning sensation on the skin
  • Redness of the skin (erythema)

Uncommon Side Effects (may affect up to 1 in 100 people):

  • Local skin reaction (contact dermatitis)
  • Skin discomfort
  • Sunburn
  • Itching of the skin (pruritus)
  • Peeling skin (exfoliation)
  • Flare-up of acne

Rare Side Effects (frequency not known):

  • Allergic contact reaction
  • Pain or swelling of the skin
  • Irritation, redness, itching, or swelling of the eyelids
  • Darkening of fair skin
  • Lightening of darker skin
  • Application site burn (including superficial burns and, in rare cases, more severe burns)

Reporting Side Effects

If you experience any side effects, talk to your doctor or pharmacist. This includes any side effects not listed here. You can also report side effects directly via the MHRA Yellow Card Scheme or by searching for "MHRA Yellow Card" in the Google Play or Apple App Store. Reporting side effects helps gather more information on the safety of this medicine.

Does Differin interact with other medicines?

  • Other Acne Treatments: You can use other acne products containing benzoyl peroxide, erythromycin, or clindamycin alongside Differin, but they should be applied in the morning while Differin is applied at night.
  • Cosmetics: You may use cosmetics, but they should not cause blackheads or excessively dry the skin.

Differin FAQs

What is Differin Gel/Cream?

Differin Gel and Cream are prescription-only topical treatments designed to treat acne. These products are ideal for individuals who prefer not to take oral antibiotics. The active ingredient, adapalene, is a retinoid that reduces inflammation and improves the appearance of blackheads, whiteheads, and pustules on the skin. Differin is available in 45-gram tubes and is typically used daily for three months to treat mild to moderate acne.

How does Differin work?

Differin contains adapalene, a derivative of vitamin A. Adapalene works by reducing the growth of keratin skin cells, which can clog pores and lead to acne. Acne-prone skin often produces excess sebum, an oily substance that, when mixed with dead skin cells, can block pores and cause blackheads, whiteheads, and spots. Differin helps to unblock pores and sebaceous glands, reducing inflammation and preventing the formation of acne. Additionally, adapalene increases the natural turnover of skin cells, aiding in the exfoliation of the skin’s outer layers and keeping pores clear.

How should I use Differin?

  • Usage: Differin is intended for use by adults and adolescents aged 12 and over.
  • Application: Apply a thin layer of Differin to the affected areas once daily, preferably at night. Make sure the skin is clean and dry before application. Rub in gently and wash your hands afterward.
  • Duration: Use Differin continuously for three months, or as directed by your doctor. Improvement should be noticeable within a few weeks, but full benefits are seen after consistent use over the three-month period.

What are the side effects of Differin?

Common side effects include:
  • Dry skin
  • Skin irritation
  • Burning sensation
  • Redness
Uncommon side effects may include:
  • Contact dermatitis
  • Skin discomfort
  • Sunburn
  • Peeling skin
  • Acne flare-up
In rare cases, serious allergic reactions may occur, such as swelling of the face, lips, or throat, which require immediate medical attention. Always read the Patient Information Leaflet for a full list of side effects and consult your doctor if you experience any severe or unusual symptoms.

What precautions should I take while using Differin?

  • Avoid: Do not apply Differin to cuts, scrapes, sunburned skin, or areas with eczema.
  • Sensitive areas: Avoid contact with the eyes, mouth, and nostrils. If contact occurs, rinse thoroughly with warm water.
  • Sun exposure: Avoid strong sunlight and artificial UV light. Use sunscreen and protective clothing when outdoors.
  • Other medications: Inform your doctor if you are using other acne products, especially those containing benzoyl peroxide, erythromycin, or clindamycin. These should be applied in the morning, while Differin is applied at night.

Can I use Differin during pregnancy or breastfeeding?

Differin should not be used during pregnancy. If you become pregnant while using Differin, discontinue use immediately and inform your doctor. While breastfeeding, avoid applying Differin to the chest area to prevent contact exposure to the infant. Always consult your doctor for advice on safe use during pregnancy and breastfeeding.

Download patient leaflet

https://www.medicines.org.uk/emc/files/pil.921.pdf

Checked By
Dr Sarah Thornton
MbChB, Coaching Academy diploma with distinction

Medical coaching


Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Independent prescriber, Superintendent pharmacist.


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