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Low Dose Naltrexone 1.5mg capsules
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Low Dose Naltrexone 1.5mg Capsules –
Low Dose Naltrexone (LDN) 1.5mg capsules are a lower-dose version of naltrexone. The usual naltrexone 50mg dose is used to treat opioid and alcohol dependence, however, when the dose is reduced to 4.5mg or lower it can be used to treat:
Autoimmune diseases, including multiple sclerosis (MS), lupus, and rheumatoid arthritis
Chronic pain conditions, such as fibromyalgia and complex regional pain syndrome
Inflammatory bowel diseases, like Crohn’s disease and ulcerative colitis
Long COVID and other chronic fatigue syndrome
Other conditions involving chronic inflammation or immune system imbalances
. These lower doses of naItrexone help regulate the immune system and so reduce inflammation.
How does Low Dose Naltrexone work?
LDN partially blocks opioid receptors, encouraging the body to overcome this block by increasing endorphin production. In additon LDN blocks Toll like receptors on immune cells and prevent their activation and so reduce inflammation.
How do you take Low Dose Naltrexone 1.5mg?
You gradually increase your dose until your reach a suitable maintenance dose.
The usual dose is 1.5mg once daily, either at night or in the morning.
Low Dose Naltrexone 1.5mg Capsules – Product Information
What is Low Dose Naltrexone (LDN) 1.5mg?
Low Dose Naltrexone (LDN) 1.5mg capsules are a specially compounded are a lower-dose formulation of naltrexone, a medication originally designed for treating opioid and alcohol dependence.
Although it is used for opioid and alcohol addiction in doses of 50mg, when the dose is reduced to around 4.5mg and lower, LDN is believed to help regulate the immune system and reduce inflammation in smaller doses.
What is Low Dose Naltrexone 1.5mg used for?
LDN 1.5mg is commonly prescribed to help manage symptoms of:
Autoimmune diseases: Including multiple sclerosis (MS), lupus, and rheumatoid arthritis.
Chronic pain conditions: Such as fibromyalgia and complex regional pain syndrome (CRPS).
Inflammatory bowel diseases: Including Crohn’s disease and ulcerative colitis.
Other conditions: Involving chronic inflammation or immune system imbalances.
How does Low Dose Naltrexone work?
LDN works by temporarily blocking opioid receptors, which encourages the body to increase its production of endorphins. Endorphins are natural chemicals that help:
Regulate immune function.
Reduce inflammation.
Improve symptoms of pain, fatigue, and immune-related conditions.
How do you take Low Dose Naltrexone 1.5mg?
The typical dose is 1.5mg once daily, usually taken before bedtime.
For some conditions, patients may start at a lower dose and gradually increase under medical supervision.
Always follow your doctor’s instructions regarding dosage.
What are the possible side effects of Low Dose Naltrexone?
Most people tolerate LDN well, but mild side effects can occur, including:
Sleep disturbances: Such as vivid dreams or trouble sleeping.
Digestive discomfort: Including nausea or an upset stomach.
Mild headaches.
These side effects often subside as your body adjusts to the medication. If symptoms persist, consult a healthcare professional.
Who should not take Low Dose Naltrexone?
LDN is not suitable for everyone. Avoid taking LDN if:
You are currently taking opioid medications, as it may block their effects and cause withdrawal symptoms.
You are pregnant or breastfeeding, unless advised by a healthcare professional.
Always inform your doctor about any medications or supplements you are taking to avoid potential interactions.
How should Low Dose Naltrexone 1.5mg be stored?
Store capsules in a cool, dry place, away from direct sunlight and moisture.
Keep out of reach of children.
Do I need a consultation before taking Low Dose Naltrexone?
Yes, LDN is a prescription-only medication, and you must consult with a healthcare provider to determine if it is suitable for your condition.
At Courier Pharmacy, you can purchase Low Dose Naltrexone 1.5mg Capsules after completing a simple online consultation with one of our healthcare professionals. With all purchases of LDN from Courier Pharmacy you are entitled to free follow up consultations with one of our specialist prescribers.
Begin your LDN consultation today
Ready to explore the benefits of Low Dose Naltrexone 1.5mg? Visit courierpharmacy.co.uk to start your online consultation and take the first step toward managing your condition safely and effectively.
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1 x 30, 2 x 30, 3 x 30
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What are Low Dose Naltrexone (LDN) 1.5mg capsules?
Low Dose Naltrexone (LDN) 1.5mg capsules are a lower-dose version of naltrexone, a medication traditionally used in 50mg doses to treat opioid and alcohol addiction [1].
LDN is specially compounded to deliver much smaller doses, typically between 1mg and 4.5mg, for alternative therapeutic purposes, such as chronic pain, fibromyalgia and autoimmune conditions [2].
If you don’t find the dose you need, please contact us, and we will compound the exact dose you need. Incidentally, this is exactly why we are listing the low-dose naltrexone in a strength of 1.5mg, which one of our patients has requested.
LDN a tale of two doses
While higher doses of naltrexone of 50mg provide a total block opioid effects, low doses are believed to regulate the immune system and reduce inflammation.
The lower dose, around 4.5mg, only partially blocks the body’s opioid receptors, allowing the body to upregulate the number of receptors and endorphins to overcome the partial block.
LDN is commonly used off-label for conditions such as fibromyalgia, multiple sclerosis, Crohn’s disease, and other autoimmune or chronic pain disorders. This is because LDN can have immune modulating effects at the lower dose.
What is the active ingredient in Low Dose Naltrexone (LDN) 1.5mg capsules?
The active ingredient in Low Dose Naltrexone (LDN) 1.5mg capsules is naltrexone hydrochloride (1.5mg).
What are Low Dose Naltrexone (LDN) 1.5mg capsules used for?
Low Dose Naltrexone (LDN) 1.5mg capsules are prescribed off-label to help manage a range of chronic and inflammatory conditions. Some of the common uses include:
Autoimmune Conditions
LDN is believed to support the immune system and reduce inflammation, making it a potential treatment for autoimmune diseases such as:
Multiple sclerosis (MS)
Rheumatoid arthritis
Lupus
Hashimoto’s thyroiditis
Chronic pain conditions
LDN is sometimes used to help with pain relief and inflammation in long-term pain disorders, including:
Fibromyalgia
Complex regional pain syndrome (CRPS)
Digestive & Inflammatory bowel disorders
LDN has shown promise in reducing gut inflammation and managing symptoms of conditions like:
Crohn’s disease
Ulcerative colitis
Irritable bowel syndrome (IBS)
Cancer support
Some patients take LDN alongside conventional cancer treatments, as it may help boost the immune system. However, more research is needed in this area.
Neurological conditions
LDN is being studied for its potential role in conditions affecting the brain and nervous system, such as:
Parkinson’s disease
Alzheimer’s disease
Since LDN is not yet widely approved for these uses, it is important to speak with a healthcare provider before starting treatment to assess whether it is suitable for your condition.
How do Low Dose Naltrexone (LDN) 1.5mg capsules work?
Low Dose Naltrexone (LDN) 1.5mg capsules work differently from the standard 50mg dose used to treat opioid addiction. When given in doses of 50mg, naltrexone provides a total block of the opioid receptors.
However, low doses (between 0.1mg and 4.5mg) only partially block them allowing the body to compensate by increasing natural endorphin production to overcome the partial block [1]. More natural endorphins equals more natural pain relief. So, think of LDN as a simple bio hack to encourage your body to increase its own natural painkillers.
The two faces of LDN
Look at your hands. They have four fingers and a thumb. They may look the same, but they are not. Have you ever tried to put a right-handed glove on your left hand? Well, the same goes for the molecule of naltrexone. There is a left-sided variety and a right-sided version.
Levo naltrexone
The left-handed version of naltrexone, or levo-naltrexone, works as we would expect by binding to the opioid receptor and blocking its effects. Remember that at the lower doses, naltrexone delivers only a partial block, allowing the body to ramp up its own endorphin production to compensate for the partial block. This explains the pain-relieving effects of LDN [2].
Dextro naltrexone
Now the right-handed version, or the dextro-naltrexone does something totally left-field (sorry couldn’t resist the pseudo pun). It doesn’t bind the opioid receptor but rather toll like receptors (TLR).
These TLRs are important in activating the immune system when there is an infection. So, inappropriate activation of these receptors can lead to activation of the immune system and the accompanying inflammation.
The immune cells of the central nervous system or CNS are called microglia and they also have the toll like receptors.
When TLRs (Toll-like receptors) are activated, they trigger inflammation, which is the body's way of defending itself. These receptors are vital for protecting us from bacterial infections and also play a role in healing and repairing tissues [3].
However, if the system that controls TLRs stops working properly, it can cause them to overreact. This overreaction can lead to a constant cycle of inflammation, which might result in long-term inflammatory conditions or autoimmune diseases [4].
So, when these TLRs are activated in the microglia they release inflammatory messengers or cytokines which then affect the nearby nerves causing the sensation of pain.
So, it is thought that LDN is able to reduce inflammation by blocking these TL4 receptors on the microglia, thus reducing the over stimulation of the immune system [5].
So, to summarise:
How LDN (Low Dose Naltrexone) works
Boosts Natural Painkillers: LDN slightly blocks opioid receptors, which signals the body to produce more endorphins—your natural painkillers. This helps manage chronic pain and supports a balanced immune system, which is especially helpful for autoimmune conditions.
Regulates the Immune System: It helps control inflammation and supports immune function, making it a promising option for autoimmune diseases and chronic pain disorders.
How LDN affects the immune system
Inflammation and TLRs: Toll-Like Receptors (TLRs) are part of the immune system that responds to infections. If they become overactive, they can cause too much inflammation, worsening autoimmune and chronic pain issues.
LDN’s Role with TLR4: LDN may reduce unnecessary inflammation by partially blocking TLR4 receptors, helping to calm and balance the immune system.
How to take Low Dose Naltrexone (LDN) 1.5mg Capsules
LDN 1.5mg capsules can be used as a step-up dose when gradually increasing your medication (titrating) or as a long-term maintenance dose, depending on how well it relieves symptoms and any side effects you experience.
LDN 1.5mg capsules dosage guidelines
Standard Dose: Take one 1.5mg capsule daily, ideally before bedtime. This helps the body produce more endorphins at the right time.
Consistency: Take the capsule at the same time every day to keep steady levels of the medication in your body.
With or without food: You can take LDN with or without food, but following the same routine daily can make it easier to stick to.
How to take LDN 1.5mg capsules: Swallow the capsule whole with a glass of water—don’t crush or chew it.
Timing adjustments: If taking LDN at night disrupts your sleep, your doctor may suggest switching to a morning dose.
Always follow your healthcare provider’s specific instructions, as they may adjust your dose or timing based on your condition and how your body responds.
Who should not use Low Dose Naltrexone (LDN)?
Opiate use and LDN
Avoid taking LDN 1.5mg capsules if you are using opiates. LDN can block the effects of opiates, and combining the two can cause serious breathing and circulation issues, increasing the risk of opiate poisoning.
If you are dependent on opiates, do not start LDN, as it may cause severe withdrawal symptoms.
In case of emergency surgery or anaesthesia, inform your healthcare provider that you are taking LDN. Non-opiate anaesthetics are preferred, but if opioids are required, higher doses may be needed under strict medical supervision, as this increases the risk of breathing and circulation problems.
Do not try to overcome LDN’s blocking effects by taking large amounts of opiates. Once LDN wears off, leftover opiates in your system could lead to an accidental overdose, which can be life-threatening.
Liver and kidney health
LDN is processed by the liver and kidneys. If you have liver issues, your doctor may monitor your liver function before and during treatment.
Other medications and LDN
Always inform your doctor about any medications you are taking, including over-the-counter drugs.
Medicines containing opiates, such as some cough syrups, painkillers, or diarrhoea treatments, may not work properly with LDN and should be avoided. Always check with your doctor or pharmacist before starting new medications.
In emergencies where opioid pain relief is necessary, higher doses might be required but must be closely supervised to manage the risk of severe side effects like breathing difficulties.
Pregnancy and breastfeeding with LDN
If you are pregnant, breastfeeding, or planning a pregnancy, consult your doctor before using LDN.
LDN should only be used during pregnancy if the benefits outweigh the risks to the baby.
Breastfeeding is not recommended while taking LDN, as it is unclear if the medication passes into breast milk.
Driving and using machinery with LDN
LDN may cause drowsiness or affect alertness in some people.
If you feel tired, dizzy, or unable to focus, avoid driving or operating heavy machinery.
Always follow your doctor’s advice and discuss any concerns or questions about LDN use.
Low Dose Naltrexone (LDN) 1.5mg capsules: Possible side effects
LDN 1.5mg capsules are usually well tolerated, but like any medication, they can cause side effects. These are generally mild and tend to improve as your body adapts to the treatment.
Common side effects
Sleep Disturbances: Some people may have vivid dreams or trouble sleeping, especially when starting LDN [1].
Digestive Issues: Mild nausea, constipation, or diarrhoea might occur during the early stages of treatment [2].
Tiredness: Feeling fatigued or drowsy can happen in some cases.
Headaches: Mild to moderate headaches are sometimes reported.
Mood Shifts: Slight changes in mood or occasional feelings of euphoria may occur.
Muscle and Joint Aches: Some users experience mild discomfort in their muscles or joints [2].
These side effects are usually temporary and tend to go away as your body adjusts to the medication. If any side effects persist or become concerning, speak with your doctor or pharmacist for guidance.
Do Low Dose Naltrexone (LDN) 1.5mg capsules interact with other medicines?
Before starting LDN, make sure to tell your doctor or pharmacist about any medications you are currently taking, have recently taken, or plan to take, including over-the-counter products.
Opioid medications and LDN
LDN works by blocking opioid receptors, which means opioid-based medications may not be as effective while you are taking it.
Some cough syrups, diarrhoea treatments, or painkillers may contain opioids, so always check with your doctor or pharmacist before using them.
Emergency pain relief
If you need opioid-based painkillers in an emergency, higher doses might be required to provide effective relief.
This must be done under strict medical supervision to manage potential risks, such as breathing problems or longer-lasting side effects.
Always consult your doctor or pharmacist about your current medications to ensure that LDN is safe and appropriate for you.
Low Dose Naltrexone (LDN) 1.5mg capsules FAQs
What is Low Dose Naltrexone (LDN)?
Low Dose Naltrexone (LDN) is a low-dose version of naltrexone, typically given in doses between 0.5mg and 4.5mg. It’s used off-label to manage chronic pain, autoimmune conditions, and support the immune system. LDN is thought to boost the body’s natural endorphins (pain-relieving chemicals) while also reducing inflammation.
How does LDN work?
LDN temporarily blocks opioid receptors, which encourages the body to produce more endorphins. These endorphins help with pain relief and balancing the immune system. LDN also helps regulate inflammation, making it useful for conditions involving chronic inflammation or immune system problems.
What conditions is LDN used for?
LDN is often prescribed to help with:
Autoimmune diseases: Such as multiple sclerosis (MS), lupus, rheumatoid arthritis, and Hashimoto’s thyroiditis.
Chronic pain disorders: Including fibromyalgia and complex regional pain syndrome (CRPS).
Inflammatory bowel diseases: Like Crohn’s disease and ulcerative colitis.
Neurological conditions: Such as Parkinson’s disease and Alzheimer’s disease.
Cancer support therapy: Used alongside other treatments in some cases.
How do I take LDN 1.5mg capsules?
Standard Dose: LDN is usually taken once a day, often before bedtime.
Timing Adjustments: If it affects your sleep, you can take it in the morning instead.
Consistency: Take it at the same time daily to keep steady levels in your body.
With or Without Food: You can take LDN with or without food based on your preference.
What are the common side effects of LDN?
Most people tolerate LDN well, but some may experience:
Sleep Problems: Vivid dreams or trouble sleeping.
Digestive Issues: Mild nausea, constipation, or diarrhoea.
Headaches: These are usually mild.
Fatigue or Mood Changes: Temporary tiredness or emotional shifts.
These side effects usually improve as your body adjusts to the medication.
Can LDN be taken with other medications?
LDN is generally safe with most medicines, but you should always let your doctor know about any medications you’re taking, especially:
Opioid-based painkillers: LDN can block their effects, making them less effective.
Immune-modulating drugs: LDN may interact with these, so medical supervision is important.
Is LDN safe for long-term use?
Yes, LDN is considered safe for long-term use. Regular check-ups with your doctor are recommended to monitor any changes in symptoms or side effects.
Can I take LDN while pregnant or breastfeeding?
LDN should only be used during pregnancy or breastfeeding if your doctor recommends it.
There isn’t enough research on its safety in these situations, so always consult a healthcare provider first.
Will stopping LDN cause withdrawal symptoms?
Unlike higher doses of naltrexone used for addiction treatment, LDN does not typically cause withdrawal symptoms. However, it’s best to stop under medical guidance to ensure a smooth process.
How long does it take for LDN to work?
Some people notice improvements within a few days, but for others, it might take weeks or even months.
The benefits of LDN build up over time, so patience is key.
Can LDN be used to treat Long COVID?
There is growing interest in using LDN to help manage symptoms of long COVID. Its ability to reduce inflammation and regulate the immune system makes it a potential option for addressing issues like fatigue, brain fog, and chronic pain. While research is still ongoing, some people have reported positive results. For more infomation, please read "Can LDN help with LOng COVID?".
