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Low Dose Naltrexone 1mg/ml solution

from£29.99

Low dose naltrexone 1mg/ml solution is a specially compounded formulation designed for convenient and efficient drug delivery. These films are commonly used in the treatment of conditions such as Multiple Sclerosis (MS), various autoimmune diseases, fibromyalgia, ulcerative colitis, irritable bowel syndrome (IBS), and pain management.

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Low Dose Naltrexone 1mg/ml solution
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1 x 100ml

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Overview

Active ingredients

What is it for?

How does it work?

How do you use it?

Warnings and precautions

Side effects

Drug interactions

FAQs

Download patent leaflet

Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Independent prescriber, Superintendent pharmacist.


Checked By
Dr Sarah Thornton
MbChB, Coaching Academy diploma with distinction

Medical coaching


What is Low Dose Naltrexone (LDN)?

Low Dose Naltrexone (LDN) is exactly what it says it is, a low dose of naltrexone. Usually, naltrexone tablets are available strengths of 50mg, but low-dose naltrexone is specially compounded to deliver lower doses of around 4.5mg. The higher doses of 50mg are used to treat addiction but for conditions such as fibromyalgia doses between 1 to 4.5mg are generally used. Naltrexone is traditionally prescribed to block the effects of opioids, but at low doses (typically 1.5 to 4.5 mg), it is believed to modulate the immune system and reduce inflammation.

LDN is used off-label to help manage a variety of conditions, including autoimmune diseases, chronic pain disorders like fibromyalgia, multiple sclerosis (MS), and inflammatory conditions such as Crohn’s disease and ulcerative colitis. The exact mechanism by which LDN works in these conditions is still being studied, but it is thought to involve the modulation of endorphins and immune response.

What is the active ingredient in Low Dose Naltrexone (LDN)?

The active ingredient is naltrexone in varying strengths of not more than 4.5mg.

What is Low Dose Naltrexone (LDN) used for?

Low Dose Naltrexone (LDN) is used off-label to manage a variety of chronic and inflammatory conditions. Some of the common uses include:

  1. Autoimmune Diseases: LDN is often used to help manage conditions like multiple sclerosis (MS), rheumatoid arthritis, lupus, and Hashimoto's thyroiditis by modulating the immune system and reducing inflammation.
  2. Chronic Pain Disorders: It is used in the treatment of chronic pain conditions such as fibromyalgia and complex regional pain syndrome (CRPS), where it may help reduce pain and improve quality of life.
  3. Inflammatory Bowel Diseases: LDN has shown promise in managing symptoms of Crohn's disease and ulcerative colitis by reducing gut inflammation.
  4. Cancer: Some patients use LDN as an adjunctive therapy in cancer treatment to enhance the immune system and potentially improve outcomes, although more research is needed in this area.
  5. Neurological Disorders: LDN is also used in conditions like Parkinson’s disease and Alzheimer’s disease to potentially slow disease progression and improve symptoms, though evidence is still emerging.
  6. Irritable Bowel Syndrome (IBS): It can help alleviate symptoms of IBS, such as abdominal pain and irregular bowel movements, by reducing intestinal inflammation.

LDN is generally well-tolerated, but it is important to consult a healthcare provider to determine if it is appropriate for your condition.

How does Low Dose Naltrexone (LDN) work?

When naltrexone is administered at a dose of 50mg, it completely blocks the opioid receptors, which is why it’s commonly used to help with addiction by preventing the euphoric effects associated with opioid use. However, at much lower doses, typically between 0.1mg and 6mg, naltrexone only partially blocks these receptors. This partial blockade prompts the body to upregulate opioid signaling and increase the production of endogenous endorphins, leading to enhanced pain relief. Researchers have also discovered that low-dose naltrexone (LDN) may significantly affect the immune system.

Many diseases are linked to immune system dysfunction. Endorphins, which primarily interact with opioid receptors, play a key role in regulating the immune system. By temporarily blocking these receptors with naltrexone, the body increases endorphin production, which can help modulate the immune response and correct immune system imbalances.

Additionally, certain endorphins regulate cell proliferation, with some capable of inhibiting cell growth, which could have implications for treating certain cancers.

The immune-modulating effects of LDN are believed to be influenced by the different isomers of naltrexone. Some drug molecules exhibit chirality, meaning they have a "left-handed" and a "right-handed" form, much like our hands. This property is important because different isomers may interact with various receptors in the body. In the case of naltrexone, the "levo" form (levo-naltrexone) blocks opioid receptors, while the "dextro" form (dextro-naltrexone) blocks Toll-Like Receptors (TLRs).

Toll-Like Receptors and Low Dose Naltrexone:

Toll-like receptors (TLRs) are a crucial part of the innate immune system, serving as the body’s first line of defense against microbial threats. These receptors are found on various immune cells, including white blood cells, dendritic cells, and others. When bacteria or viruses invade the body, TLRs recognize specific components of these pathogens, triggering an immune response.

Activation of TLRs leads to the production of pro-inflammatory cytokines, which are small proteins that help coordinate the immune response. For instance, they can signal white blood cells to attack the invading pathogen or instruct infected cells to undergo programmed cell death. A key molecule in this process is NF-kB, which plays a significant role in inflammation and has been linked to the expression of oncogenes, which can lead to uncontrolled cancer cell growth.

However, TLRs can also be activated inappropriately, leading to excessive inflammation. Levo-naltrexone, by antagonizing TLR4 receptors, can help suppress this unwarranted inflammatory response. Studies have shown that naltrexone’s inhibition of TLR4 can alleviate symptoms of neuropathic pain, highlighting the therapeutic potential of this pathway.

Thus, the wide-ranging effects of naltrexone are largely due to its chiral nature. In its formulated state, naltrexone consists of a 50:50 mixture of levo and dextro isomers. Levo-naltrexone primarily acts on opioid receptors, promoting endorphin release, immune modulation, and reducing cell proliferation. Meanwhile, dextro-naltrexone antagonizes TLRs, suppressing cytokine-driven inflammation, reducing NF-kB production, and potentially downregulating oncogenes, contributing to its anti-inflammatory and possible anticancer effects.

How do you use Low Dose Naltrexone (LDN)?

To use Low Dose Naltrexone (LDN) 1mg/ml solution, start with a lower dose and gradually increase it as directed by your healthcare provider. Typically, you begin with a low dose, such as 1mg, and then titrate up gradually to a maximum dose of 4.5mg, depending on your individual response and tolerance. Follow your doctor’s instructions carefully to ensure the best results.

Who should not use Low Dose Naltrexone (LDN)?

Avoid taking opiates while using low-dose naltrexone 4.5mg transmucosal buccal film tablets. Although this medication generally blocks some of the effects of opiates (such as the euphoric "high"), taking high doses of opiates can still lead to severe breathing difficulties and circulatory problems, which could result in opiate poisoning.

  • Do not use low-dose naltrexone 4.5mg transmucosal buccal film if you are still dependent on opiates, as it can trigger severe withdrawal symptoms.
  • Be sure to inform every healthcare provider that you are using low-dose naltrexone 4.5mg transmucosal buccal film. If you require anesthesia in an emergency, non-opiate-based anesthetics should be used. If opiate-containing anesthetics are necessary, higher doses may be required, and you may be more susceptible to side effects such as breathing difficulties and circulatory issues.
  • Do not attempt to counteract the blocking effects of low-dose naltrexone 4.5mg transmucosal buccal film by taking high doses of opiates. There is a risk that opiates could remain in your system after the effects of naltrexone have worn off, potentially leading to an unintentional overdose with serious consequences.
  • Low-dose naltrexone 4.5mg transmucosal buccal film is metabolized by the liver and kidneys. Since liver problems are common in individuals with opiate dependence, your doctor will perform liver function tests before and during treatment.

Other Medicines and Low-Dose Naltrexone 4.5mg Transmucosal Buccal Film:

Inform your doctor if you are taking, have recently taken, or might take any other medications, including those obtained without a prescription. Some common medications contain opiates and may not be effective while you are using low-dose naltrexone 4.5mg transmucosal buccal film.

If you need cough syrups, medications for diarrhea, or pain relievers, inform your doctor, as these may contain opiates. In emergency cases where opioid-containing drugs are required, the necessary dose for pain relief may be higher than usual. Close medical supervision is essential, as respiratory depression and other symptoms may be more intense and prolonged.

Low-Dose Naltrexone 4.5mg Transmucosal Buccal Film with Food and Drink:

Food and drink do not interfere with the effects of low-dose naltrexone 4.5mg transmucosal buccal film.

Pregnancy and Breastfeeding:

If you are pregnant, breastfeeding, think you may be pregnant or are planning to have a baby, consult your doctor or pharmacist before taking this medication. Low-dose naltrexone 4.5mg transmucosal buccal film should only be used during pregnancy if the potential benefit to the mother outweighs the possible risks. Breastfeeding is not recommended while taking this medication. Always consult your doctor for advice.

Driving and Using Machines:

Low-dose naltrexone 4.5mg transmucosal buccal film may cause drowsiness or reduce alertness. Do not drive or operate machinery if you experience these effects.

What are the side effects of Low Dose Naltrexone (LDN)?

Like all medicines, this medication may cause side effects, although not everyone experiences them. The most serious side effects associated with low-dose naltrexone include feelings of depression, suicidal thoughts, attempted suicide, and hallucinations. Although these side effects are rare or uncommon, it is essential to contact your doctor or pharmacist immediately if you experience any of these symptoms to receive help and support.

The following side effects of low-dose naltrexone 4.5mg transmucosal buccal film are categorized by frequency:

  • Very Common (may affect more than 1 in 10 patients): Anxiety, insomnia, vivid dreams, headache, restlessness, nervousness, abdominal pain, nausea, vomiting, joint and muscle pain, weakness.
  • Common (may affect up to 1 in 10 patients): Decreased appetite, heart palpitations, increased heart rate, ECG anomalies, libido disorders, thirst, dizziness, excessive tear production, chest pain, diarrhea, constipation, rash, delayed ejaculation, erectile dysfunction, increased energy, irritability, increased sweating, mood disorders.
  • Uncommon (may affect up to 1 in 100 patients): Oral herpes, athlete’s foot, swollen lymph nodes, hallucinations, confusion, depression, paranoia, disorientation, nightmares, agitation, abnormal dreams, shaking, drowsiness, vision problems, eye irritation and swelling, sensitivity to light, eye pain or fatigue, eye strain, blood pressure changes, hot flashes, nasal congestion, nasal discomfort, runny nose, sneezing, mouth and throat disorders, excess mucus production, sinus issues, voice changes, coughing, shortness of breath, yawning, flatulence, hemorrhoids, ulcers, dry mouth, liver disorders, increased bilirubin, hepatitis, seborrhea, acne, hair loss, itching, groin pain, frequent urination, painful urination, tinnitus, vertigo, ear pain or discomfort, increased appetite, weight loss or gain, fever, pain, cold sensations in the extremities.
  • Rare (may affect up to 1 in 1,000 patients): Reduced platelet count, suicidal thoughts, attempted suicide.
  • Very Rare (may affect up to 1 in 10,000 patients): Breakdown of skeletal muscle tissue.

Reporting of Side Effects: If you experience any side effects, speak to your doctor or pharmacist. This includes any side effects not listed in this leaflet. You can also report side effects through the Yellow Card Scheme at www.mhra.gov.uk/yellowcard or by searching for "MHRA Yellow Card" on the Google Play or Apple App Store. Reporting side effects helps to improve the safety information available for this medication.

Does Low Dose Naltrexone (LDN) interact with other medicines?

Inform your doctor if you are currently taking, have recently taken, or plan to take any other medications, including those available over the counter. Some common medications contain opiates and may not work effectively while you are using low-dose naltrexone.

If you require cough syrups, diarrhea medications, or pain relievers, let your doctor know, as these might contain opiates. In emergency situations where opioid-containing drugs are necessary, higher doses may be required for effective pain relief. Close medical supervision is crucial, as there is an increased risk of respiratory depression and other prolonged or intensified side effects.

Low Dose Naltrexone (LDN) FAQs

What is the active ingredient in Low Dose Naltrexone (LDN) 1mg/ml solution?

The active ingredient is naltrexone hydrochloride, with a concentration of 1mg per milliliter.

What is Low Dose Naltrexone (LDN) 1mg/ml solution used for?

Low Dose Naltrexone (LDN) 1mg/ml solution is commonly used to manage various conditions, including autoimmune diseases, chronic pain disorders, and inflammatory conditions. The lower doses are known to have an immunomodulatory and analgesic effect.

How should I take Low Dose Naltrexone (LDN) 1mg/ml solution?

The solution is typically started at a low dose, such as 1mg, and then gradually increased, or titrated, up to a maximum of 4.5mg, as directed by your healthcare provider. Your doctor will guide you on the appropriate dosing schedule.

What should I do if I miss a dose of Low Dose Naltrexone (LDN) 1mg/ml solution?

If you miss a dose, take it as soon as you remember. If it’s nearly time for your next dose, skip the missed dose and continue with your regular schedule. Do not take an extra dose to make up for the one you missed.

What are the potential side effects of Low Dose Naltrexone (LDN) 1mg/ml solution?

Side effects may include nausea, headache, dizziness, sleep disturbances, and fatigue. If you experience any persistent or worsening side effects, consult your healthcare provider.

Can I drink alcohol while taking Low Dose Naltrexone (LDN) 1mg/ml solution?

It is recommended to avoid alcohol while taking Low Dose Naltrexone, as the medication is designed to discourage alcohol consumption.

Can I take Low Dose Naltrexone (LDN) if I am pregnant?

LDN should only be used during pregnancy if absolutely necessary and prescribed by your doctor. Discuss the potential risks and benefits with your healthcare provider before use.

Can I drive or operate machinery while taking Low Dose Naltrexone (LDN) 1mg/ml solution?

LDN may cause dizziness or drowsiness. You should avoid driving or operating machinery until you are certain that the medication does not impair your ability to do so safely.

What should I do in case of an overdose?

If an overdose occurs and serious symptoms such as trouble breathing or loss of consciousness arise, seek emergency medical help immediately.

How should I store Low Dose Naltrexone (LDN) 1mg/ml solution?

The solution should be stored in the refrigerator to maintain its stability and effectiveness. Be sure to follow the storage instructions provided by your pharmacist or healthcare provider.

Download patient leaflet

Low Dose Naltrexone Patient Information Leaflet

Checked By
Dr Sarah Thornton
MbChB, Coaching Academy diploma with distinction

Medical coaching


Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Independent prescriber, Superintendent pharmacist.


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