What are Low Dose Naltrexone (LDN) 3.5mg capsules?
Low Dose Naltrexone (LDN) 3.5mg capsules are exactly what it says it is, a low dose of naltrexone. Usually, licensed naltrexone tablets are available strengths of 50mg, but low-dose naltrexone is specially compounded to deliver lower doses of no more than 4.5mg.
The higher doses of 50mg are used to treat addiction but for conditions such as fibromyalgia doses between 1 to 4.5mg are generally used. Naltrexone is traditionally prescribed to block the effects of opioids, but at low doses (typically 1.5 to 4.5 mg), it is believed to modulate the immune system and reduce inflammation.
Low Dose Naltrexone (LDN) 3.5mg capsules are a lower-dose formulation of naltrexone, a medication originally used to treat opioid and alcohol dependence. In low doses, naltrexone is believed to help regulate the immune system and reduce inflammation, making it a potential treatment option for various autoimmune and chronic pain conditions, such as multiple sclerosis, fibromyalgia, and Crohn’s disease. LDN is typically taken once daily and is used off-label for these purposes, meaning it is not yet FDA-approved specifically for these conditions.
What is the active ingredient in Low Dose Naltrexone (LDN) 3.5mg capsules?
The active ingredient in the lo dose naltrexone capsules is naltrexone hydrochloride 3.5mg.
What are the Low Dose Naltrexone (LDN) 3.5mg capsules used for?
Low Dose Naltrexone (LDN) 3.5mg capsules are used off-label to manage a variety of chronic and inflammatory conditions. Some of the common uses include:
- Autoimmune Diseases: LDN is often used to help manage conditions like multiple sclerosis (MS), rheumatoid arthritis, lupus, and Hashimoto's thyroiditis by modulating the immune system and reducing inflammation.
- Chronic Pain Disorders: It is used in the treatment of chronic pain conditions such as fibromyalgia and complex regional pain syndrome (CRPS), where it may help reduce pain and improve quality of life.
- Inflammatory Bowel Diseases: LDN has shown promise in managing symptoms of Crohn's disease and ulcerative colitis by reducing gut inflammation.
- Cancer: Some patients use LDN as an adjunctive therapy in cancer treatment to enhance the immune system and potentially improve outcomes, although more research is needed in this area.
- Neurological Disorders: LDN is also used in conditions like Parkinson’s disease and Alzheimer’s disease to potentially slow disease progression and improve symptoms, though evidence is still emerging.
- Irritable Bowel Syndrome (IBS): It can help alleviate symptoms of IBS, such as abdominal pain and irregular bowel movements, by reducing intestinal inflammation.
Low-dose naltrexone or LDN is generally well-tolerated, but it is important to consult a healthcare provider to determine if it is appropriate for your condition.
How do you use Low Dose Naltrexone (LDN) 3.5mg capsules?
To use Low Dose Naltrexone (LDN) 3mg capsules, follow these general guidelines:
- Dosage: Take one 3.5mg capsule daily, preferably at bedtime. The timing helps to align with the body's natural rhythms and optimise endorphin production.
- Consistency: Take the capsule at the same time each day to maintain steady levels in the body.
- With or Without Food: Low-dose naltrexone or LDN can be taken with or without food, but maintaining a consistent routine can help with adherence.
- Swallowing: Swallow the capsule whole with water. Do not crush or chew the capsule.
- Alternative Timing: If taking LDN at night disturbs your sleep, you can switch to taking it in the morning, as advised by your healthcare provider.
Always follow the specific instructions provided by your healthcare provider, who may adjust the dose or timing based on your individual needs and condition.
Who should not use Low Dose Naltrexone (LDN)?
Avoid taking opiates while using low-dose naltrexone 4.5mg capsules. Although this medication generally blocks some of the effects of opiates (such as the euphoric "high"), taking high doses of opiates can still lead to severe breathing difficulties and circulatory problems, which could result in opiate poisoning.
- Do not use low-dose naltrexone 4.5mg capsules if you are still dependent on opiates, as it can trigger severe withdrawal symptoms.
- Be sure to inform every healthcare provider that you are using low-dose naltrexone 4.5mg capsules If you require anesthesia in an emergency, non-opiate-based anesthetics should be used. If opiate-containing anesthetics are necessary, higher doses may be required, and you may be more susceptible to side effects such as breathing difficulties and circulatory issues.
- Do not attempt to counteract the blocking effects of low-dose naltrexone 4.5mg capsules by taking high doses of opiates. There is a risk that opiates could remain in your system after the effects of naltrexone have worn off, potentially leading to an unintentional overdose with serious consequences.
- Low-dose naltrexone 4.5mg capsules are metabolised by the liver and kidneys. Since liver problems are common in individuals with opiate dependence, your doctor will perform liver function tests before and during treatment.
Other Medicines and Low-Dose Naltrexone 4.5mg capsules:
Inform your doctor if you are taking, have recently taken, or might take any other medications, including those obtained without a prescription. Some common medications contain opiates and may not be effective while you are using low-dose naltrexone 4.5mg capsules.
If you need cough syrups, medications for diarrhea, or pain relievers, inform your doctor, as these may contain opiates. In emergency cases where opioid-containing drugs are required, the necessary dose for pain relief may be higher than usual. Close medical supervision is essential, as respiratory depression and other symptoms may be more intense and prolonged.
Pregnancy and Breastfeeding:
If you are pregnant, breastfeeding, think you may be pregnant or are planning to have a baby, consult your doctor or pharmacist before taking this medication. Low-dose naltrexone 3.5mg capsules should only be used during pregnancy if the potential benefit to the mother outweighs the possible risks. Breastfeeding is not recommended while taking this medication. Always consult your doctor for advice.
Driving and Using Machines:
Low-dose naltrexone 3mg capsules may cause drowsiness or reduce alertness. Do not drive or operate machinery if you experience these effects.
Does Low Dose Naltrexone (LDN) 3.5mg capsules interact with other medicines?
Inform your doctor if you are currently taking, have recently taken, or plan to take any other medications, including those available over the counter. Some common medications contain opiates and may not work effectively while you are using low-dose naltrexone.
If you require cough syrups, diarrhea medications, or pain relievers, let your doctor know, as these might contain opiates. In emergency situations where opioid-containing drugs are necessary, higher doses may be required for effective pain relief. Close medical supervision is crucial, as there is an increased risk of respiratory depression and other prolonged or intensified side effects.
