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Nystan (Nystatin) Oral Suspension

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Nystan Oral Suspension is an antifungal medication specifically designed to treat and prevent oral thrush (oral candidiasis) in individuals over the age of 18. Each 30ml bottle contains the active ingredient nystatin and includes an applicator for easy application directly to the mouth.

Nystan is used to effectively treat oral thrush by targeting the fungus responsible for the infection. If you’re over 18 and experiencing irritation caused by oral thrush, you can obtain a prescription for Nystan (nystatin) online. Additionally, if you suffer from recurrent oral thrush, you can find prevention tips to help reduce the chances of your symptoms returning.

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Nystan (Nystatin) Oral Suspension

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Quantity

1 x 30ml bottle, 2 x 30ml bottle

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Overview

Active ingredients

What is it for?

How does it work?

How do you use it?

Warnings and precautions

Side effects

Drug interactions

FAQs

Download patent leaflet

Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Superintendant Pharmacist, Independent Prescriber


Checked By
Dr Sarah Thornton
MbChB, Coaching Academy diploma with distinction

GP, Medical coach


What is Nystan?

Nystan, which contains the active ingredient nystatin, is an antifungal antibiotic medication specifically used to prevent and treat oral thrush, also known as oral candidiasis or candidal infections. Oral thrush is caused by an overgrowth of the Candida fungus in the mouth, leading to symptoms such as white patches, soreness, and difficulty swallowing.

Nystan oral suspension is designed for use in individuals over the age of 18 and is particularly effective in targeting fungal infections within the mouth. The medication works by binding to the fungal cell membrane, causing the contents of the cell to leak out, ultimately killing the fungus and clearing the infection.

The 30ml bottle of Nystan comes with a built-in applicator, making it convenient to apply directly to the affected areas in the mouth. The suspension is typically swished around the mouth or held in place for a few minutes before swallowing, allowing the medication to work effectively on the infected areas. Nystan is often prescribed for those with weakened immune systems, individuals using inhaled corticosteroids, or those who have had recent antibiotic treatment, as these factors can increase the risk of developing oral thrush.

What is the active ingredient in Nystan?

The active substance in Nystan: Each 1ml contains 100,000 units of nystatin.

What is Nystan used for?

Nystan (nystatin) is primarily used to treat and prevent oral thrush (oral candidiasis), which is a fungal infection caused by Candida species. This condition typically manifests as white patches or irritation in the mouth, throat, or on the tongue. Nystan is an antifungal medication that works by stopping the growth of the fungus, helping to alleviate the symptoms and clear the infection. It is commonly prescribed for individuals who are prone to oral thrush, such as those with weakened immune systems, people using inhaled corticosteroids, or those taking certain antibiotics.

How does Nystan work?

Nystan (nystatin) works by targeting the fungal cells responsible for infections like oral thrush. It is an antifungal antibiotic that binds to a specific component in the cell membrane of the fungus called ergosterol. Ergosterol is essential for maintaining the integrity of the fungal cell membrane. When nystatin binds to ergosterol, it disrupts the cell membrane, causing it to become porous. This disruption allows essential contents of the fungal cell to leak out, leading to cell death. By killing the fungus or stopping its growth, Nystan helps to eliminate the infection and relieve the symptoms associated with oral thrush, such as soreness, irritation, and the appearance of white patches in the mouth. Because it acts directly on the fungus, Nystan is effective in treating localized fungal infections in the mouth and throat without being absorbed into the bloodstream, which minimizes the risk of systemic side effects.

How do you use Nystan?

Always take this medication exactly as prescribed by your doctor or pharmacist. If you are unsure about the instructions, consult your healthcare provider.

Recommended Dosage:

  • Adults and Children: 1 ml of suspension should be placed in the mouth four times a day.
  • Newborns: The recommended dose is 1 ml once a day, placed in the mouth.
  • There are no specific dosage adjustments needed for older adults.

Instructions for Use:

  1. Shake the bottle well before each use.
  2. Measuring the Dose:
    • Use the provided measuring syringe, which is marked in 0.5 ml increments.
    • Doses should be spaced evenly throughout the day.

Using the Syringe:

  • For First Use:
    1. Remove the adapter from the syringe.
    2. Remove the cap from the bottle.
    3. Insert the adapter into the bottle.
    4. Secure the adapter in the bottle.
  • For Each Use:
    1. Shake the bottle well.
    2. Attach the syringe to the adapter.
    3. Invert the bottle and syringe assembly.
    4. Fill the syringe with the suspension by pulling the plunger and then push it back slightly to remove any air bubbles.
  • Administering the Dose:
    1. Make sure the plunger is fully depressed.
    2. Slowly pull the plunger to draw the required dose.
    3. Remove the syringe from the bottle and gently turn it to release any remaining liquid.
    4. Insert the syringe tip into the mouth and slowly press the plunger to administer the medication.

After Use:

  1. Close the bottle with the cap, leaving the adapter in place.
  2. Rinse the syringe with water and store it in the provided case.
  3. Keep the syringe with the rest of the medicine's packaging for future use.

Important Notes:

  • If treating an oral or throat infection, avoid swallowing the suspension too quickly to maximize its contact time with the affected area.
  • Continue using the medication for 48 hours after symptoms disappear to ensure the infection is fully treated and to prevent relapse.
  • If symptoms worsen or persist beyond 14 days, consult your doctor.

Missed Dose:

  • If you forget a dose, take it as soon as you remember unless it's almost time for your next dose. Do not double up on doses to make up for a missed one.

Overdose:

  • Taking more than the recommended dose is unlikely to cause serious effects, as nystatin is minimally absorbed by the body. However, in rare cases, very high doses might cause nausea or gastrointestinal discomfort. If this occurs, especially in children, seek medical advice.
If you have any further questions, consult your doctor or pharmacist.

Who should not use Nystan?

When Not to Take Nystan Oral Suspension:

  • Do not use Nystan Oral Suspension if you are allergic to nystatin or any of the other ingredients listed in this medication.

Warnings and Precautions:

  • Consult Your Doctor: Speak with your doctor or pharmacist before using Nystan Oral Suspension, especially if you have a fungal infection in the lungs or on the skin (systemic mycoses), as Nystan may not be suitable for such conditions.

Pregnancy, Breast-feeding, and Fertility:

  • If Pregnant or Breast-feeding: If you are pregnant, breastfeeding, think you might be pregnant, or are planning to have a baby, seek advice from your doctor or pharmacist before taking Nystan.
  • Uncertain Effects: While it is not known if Nystan can harm an unborn baby or affect your ability to conceive, absorption of Nystan through the digestive system is minimal. It is also not known if Nystan is excreted in breast milk, so caution is advised when using this medication while breastfeeding.

Driving and Using Machines:

  • No Impact on Driving: Nystan Oral Suspension is not expected to affect your ability to drive or operate machinery.

Ingredients and Potential Reactions:

  • Allergic Reactions: Nystan Oral Suspension contains methyl parahydroxybenzoate (E218) and propyl parahydroxybenzoate (E216), which may cause allergic reactions, possibly with a delayed onset.
  • Alcohol Content: This medication contains a small amount of alcohol (ethanol) — specifically, 228 mg in each 30 ml dose, which is equivalent to less than 0.2 ml of beer or 0.1 ml of wine. This small amount of alcohol is not expected to have any noticeable effects.
  • Sodium Content: Nystan Oral Suspension contains less than 1 mmol of sodium (23 mg) per dose, making it essentially "sodium-free."
  • Sugar Intolerance: If you have been advised by your doctor that you have an intolerance to some sugars, consult your doctor before using this product.

What are the side effects with Nystan?

Like all medicines, Nystan Oral Suspension can cause side effects, although not everyone will experience them. If you notice irritation or sensitization, stop using the treatment immediately. Nausea has been reported occasionally during therapy. In rare cases, large oral doses can cause:
  • Nausea and vomiting
  • Diarrhea
  • Bloating
  • Stomach cramps or indigestion
Other side effects that have been reported include:
  • Rash, including urticaria (itching)
  • Hypersensitivity reactions
  • Angioedema (swelling of the lips or tongue)
  • Facial edema (swelling of the face)
There have also been very rare cases of a more serious allergic reaction known as Stevens-Johnson Syndrome, which involves severe blistering of the skin, mouth, eyes, and genitals.

Reporting Side Effects:

If you experience any side effects, speak with your doctor, pharmacist, or nurse. This includes any potential side effects not listed in the leaflet. You can also report side effects directly through the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard.  

Does Nystan interact with other medicines?

Nystan (nystatin) is generally considered to have a low potential for interactions with other medications because it is not significantly absorbed into the bloodstream when used as an oral suspension. This means it primarily works locally in the mouth and digestive tract without affecting other areas of the body. However, it's always important to discuss all the medications you are taking with your healthcare provider to ensure there are no potential interactions.

General Advice:

  • Consult Your Doctor or Pharmacist: Always inform your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including over-the-counter medications, supplements, or herbal products.
  • Oral Contraceptives: There is no evidence to suggest that Nystan affects the efficacy of oral contraceptives.
  • Other Medications: Since Nystan is not absorbed into the bloodstream in significant amounts, it typically does not interact with systemic medications. However, if you are on multiple treatments, it’s a good idea to confirm this with your healthcare provider.

Special Considerations:

  • Tell Your Healthcare Provider: Always keep your healthcare provider informed about all your medications, especially if you have any existing conditions that require you to take multiple drugs.
If you have any concerns about potential interactions or side effects, it’s best to consult with your doctor or pharmacist.

Nystan FAQs

What is Nystan (nystatin)?

Nystan Oral Suspension is an antifungal medication specifically designed to treat and prevent oral thrush (oral candidiasis) in individuals over the age of 18. Each 30ml bottle contains the active ingredient nystatin and includes an applicator for easy application directly to the mouth.

What is Nystan Oral Suspension used for?

Nystan is used to effectively treat oral thrush by targeting the fungus responsible for the infection. If you're over 18 and experiencing irritation caused by oral thrush, you can obtain a prescription for Nystan (nystatin) online. Additionally, if you suffer from recurrent oral thrush, you can find prevention tips to help reduce the chances of your symptoms returning.

How is Nystatin used to treat fungal infections?

Nystatin is administered orally, with a recommended dose of 1ml taken four times a day. In the case of newborn babies, the recommended dose is 1 ml once a day dropped into the mouth. is diThe active ingredient works directly at the site of infection, and most users notice an improvement within the first two days of treatment.

How does Nystatin work for oral thrush?

Nystatin combats oral thrush by attacking the fungal cells, causing the contents of the cells to leak out, which prevents them from growing or surviving.

Are there any alternatives to Nystan?

Nystatin is a prescription-only treatment for oral thrush, available for individuals aged 18 and over. An over-the-counter alternative is Daktarin Oral Gel, which can be used by adults and children over 4 months old.

How to take Nystan?

  • Adults over 18 should take 1ml of Nystan, 4 times daily.
  • Use the measuring dropper to administer the dose, swish it around your mouth, and then swallow.
  • It's recommended to take Nystan after meals.
  • Continue the treatment for 48 hours after symptoms have cleared to prevent reinfection.
  • If your symptoms persist or worsen after 14 days, consult a doctor or pharmacist.

What are the ingredients in Nystan?

The active ingredient: Nystatin (100,000 units per 1ml). Inactive ingredients include ethanol, glycerine, and several other compounds. Always read the Patient Information Leaflet before using Nystan.

What are the side effects associated with Nystan?

Common side effects may include nausea, vomiting, diarrhea, bloating, and rashes. If you experience severe side effects or allergic reactions, seek medical attention immediately.

Nystan warnings

  • Consult your doctor if you have a fungal infection in the lungs or skin before using Nystan.
  • Discuss with a healthcare professional if you're taking any other medications.
  • If you're pregnant or breastfeeding, ask your doctor or pharmacist for advice before using Nystan.

Download patient leaflet

https://www.medicines.org.uk/emc/files/pil.408.pdf

Checked By
Dr Sarah Thornton
MbChB, Coaching Academy diploma with distinction

GP, Medical coach


Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Superintendant Pharmacist, Independent Prescriber


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