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Phenergan 25mg tablets

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Phenergan (generic name: promethazine) is a medication primarily used to treat allergy symptoms such as itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes. Additionally, it can be used to prevent motion sickness, and to induce sedation. It works by blocking histamines and acetylcholine in the body, which helps reduce symptoms. Phenergan is available in various forms, including tablets and liquid form. It is important to use this medication under the guidance of a healthcare provider due to potential side effects such as drowsiness, dizziness, and more serious reactions in some cases.

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Phenergan 25mg tablets
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Overview

Active ingredients

What is it for?

How does it work?

How do you use it?

Warnings and precautions

Side effects

Drug interactions

FAQs

Download patent leaflet

Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Independent prescriber, Superintendent pharmacist.


Checked By
Dr Sarah Thornton
MbChB, Coaching Academy diploma with distinction

Medical coaching


What is Phenergan?

Phenergan, containing the active ingredient promethazine, is an antihistamine often used to promote sleep due to its sedative properties. It works by blocking certain receptors in the brain, not only alleviating allergy symptoms but also inducing a calming effect. This makes Phenergan particularly useful for individuals needing help with relaxation and managing sleep disturbances related to allergies. However, its strong sedative effects mean it should be used carefully under medical supervision to avoid impairing activities that require alertness.

What is the active ingredient in Phenergan?

The active ingredient is promethazine.

What is Phenergan used for?

Phenergan is used to address a variety of conditions including:
  • Treating allergic reactions like hay fever or rashes (such as nettle rash or hives)
  • Managing nausea or preventing vomiting, as may be experienced with motion sickness
  • For short-term relief of insomnia in adults
  • Temporarily as a sedative for children aged 6 years and older

How does Phenergan work?

Phenergan, which contains promethazine as its active ingredient, primarily functions as an antihistamine. It works by blocking histamine receptors in the brain and other parts of the body. Histamine is a chemical released during allergic reactions that contributes to inflammation, swelling, and the typical symptoms of an allergy like itching and runny nose.

In addition to its antihistamine properties, Phenergan affects other receptor systems in the body:

  • It blocks certain acetylcholine receptors, which helps reduce nausea and motion sickness.
  • It has sedative effects because it also influences the central nervous system, inducing a calming effect which can be beneficial for inducing sleep.

These actions make Phenergan effective not only in treating allergic reactions but also in managing conditions like insomnia, nausea, and motion sickness by calming and stabilizing bodily responses.

How do you use Phenergan?

Ensure that you always use this medication as instructed in the accompanying leaflet or as advised by your doctor or pharmacist. If you are uncertain, consult with your healthcare provider. The appropriate dosage of Phenergan Tablets depends on the reason for use. The guidelines below can help determine the necessary amount:

How to Take Phenergan:

  • Administer orally.
  • Do not use for more than 7 days.
  • If symptoms worsen or do not improve after 7 days, consult your doctor or pharmacist.
  • Follow dosage recommendations strictly and avoid exceeding the suggested amount.
  • If you feel the medication's effect is too weak or too strong, consult your doctor before adjusting the dose.

Dosage Instructions:

  • For allergies (e.g., hay fever, rashes, hives):
    • Children 6-10 years: One 25mg tablet at night. Do not exceed 25mg per day.
    • Children over 10 years and adults (including the elderly): Start with one 25mg tablet at night. If needed, increase to one 25mg tablet twice a day.
  • For prevention and treatment of nausea and vomiting (e.g., travel sickness):
    • Children 6-10 years: Use Phenergan Elixir.
    • Children over 10 years and adults (including the elderly): One 25mg tablet the night before travel. A second dose can be taken 6-8 hours later if necessary.
  • As a short-term pediatric sedative and for short-term treatment of adult insomnia:
    • Children 6-10 years: One 25mg tablet at night.
    • Children over 10 years and adults (including the elderly): One or two 25mg tablets at night.

In Case of Overdose:

  • Immediately inform a doctor or visit an emergency department if you or your child takes more Phenergan Tablets than recommended. Bring the medication packaging for reference. Overdose symptoms may include seizures, reduced consciousness, coma, irregular heartbeat, and depressed breathing. Children might also experience hyperactivity, involuntary movements, hallucinations, and cognitive impairments.

If You Miss a Dose:

  • Do not double the dose to compensate for a missed one.
  • If taking for an allergic condition, take the missed dose as soon as you remember, then continue as usual.
  • If taking for sedation or sleep issues, skip the missed dose and take the next dose the following evening as scheduled.

For any further questions regarding this medication, consult your doctor or pharmacist.

Who should not use Phenergan?

Do not use Phenergan Tablets if:

  • The individual taking the medication is under 6 years old.
  • You have allergies to promethazine hydrochloride or any other ingredients in this medication, please refer to the patient information leaflet. Signs of an allergic reaction include rashes, difficulty swallowing or breathing, and swelling of the lips, face, throat, or tongue.
  • You are currently taking or have taken a monoamine oxidase inhibitor (MAOI) for depression within the last 14 days.
  • The individual is in a coma or experiencing severe dizziness, drowsiness, or headache.

If any of the above situations apply to you, or if you are uncertain, consult your doctor or pharmacist before using Phenergan Tablets.

Warnings and Precautions:

Consult with your doctor or pharmacist before taking Phenergan Tablets if you:

  • Have respiratory issues like asthma, tightness in the chest, or bronchitis.
  • Suffer from seizure disorders such as epilepsy.
  • Experience an allergic reaction to this medication; seek immediate medical attention.
  • Have serious heart conditions or a family history of heart disease.
  • Have an irregular heartbeat.
  • Develop a fever or infection, as you may need lab tests to check your blood count.
  • Have liver or kidney issues.
  • Suffer from stomach blockage or difficulty urinating.
  • Have hearing impairments.
  • Are diagnosed with narrow-angle glaucoma.
  • Have had or are suspected to have Reye's Syndrome, characterized by vomiting and confusion after a viral illness.

Sun Exposure: Phenergan Tablets can increase your skin's sensitivity to sunlight. Avoid direct sun exposure while taking this medication.

Impact on Diagnostic Tests: Phenergan may alter the results of certain tests, including some pregnancy tests and skin tests. Avoid taking this medication for at least 3 days before undergoing a skin test.

If you are unsure about any of the above points, discuss with your doctor or pharmacist before taking Phenergan Tablets. Additionally, do not administer this medication to children under 6 years old or to those who have difficulty swallowing tablets due to the risk of choking.

What are the side effects with Phenergan?

Phenergan Tablets, like all medications, may cause side effects, but not everyone experiences them. If you notice any of the following severe side effects, immediately stop taking Phenergan and seek medical attention:

  • Allergic Reactions: These can be life-threatening and may occur soon after taking the drug or several days later. Symptoms include rashes, itching, difficulty breathing, swelling of the face, lips, throat, or tongue, cold and clammy skin, palpitations, dizziness, weakness, or fainting.
  • Liver Issues: Signs such as yellowing of the skin or eyes (jaundice) and dark urine.
  • Neuromuscular Symptoms: Muscle stiffness, shaking, unusual tongue movements, facial muscle spasms, uncontrolled facial muscles, eye rolling, or trembling.
  • Heart Issues: Very fast, irregular, or forceful heartbeat (palpitations).
  • Blood Disorders: General weakness, frequent infections (especially throat infections), and fever related to blood changes like agranocytosis and eosinophilia (increased white blood cells), detectable via blood tests.
  • Thrombocytopenia: A decrease in blood platelets leading to bleeding and bruising, identified through a blood test.
  • Chronic Fatigue: Persistent tiredness which may be due to anaemia.
  • Behavioral Changes: Aggression, hallucinations, and hyperactivity, particularly in children.

If the following side effects become serious or persist for more than a few days, consult your doctor or pharmacist:

  • Dry mouth, blurred vision, or difficulty urinating.
  • Drowsiness, fatigue, disorientation, nightmares, headaches, or restlessness.
  • Loss of appetite, indigestion, or stomach irritation.
  • Dizziness, lightheadedness, fainting (hypotension).
  • Confusion, particularly in elderly individuals.
  • Increased sensitivity to sunlight. If this occurs, stay out of direct sunlight and avoid sun lamps.
  • Restless Legs Syndrome, an overwhelming urge to move your legs.

Reporting of Side Effects: If you experience any side effects, discuss them with your doctor, pharmacist, or nurse. This includes effects not listed in the medication leaflet. You can also report side effects directly via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard, or through the MHRA Yellow Card mobile app. Reporting side effects contributes to the safety information on this medication.

Does Phenergan interact with other medicines?

Inform your doctor or pharmacist if you are taking, have recently taken, or might take any other medications. This includes over-the-counter medicines and herbal supplements, as Phenergan Tablets can interact with other drugs, affecting how they work or how Phenergan works. Particularly important to mention are:

  • Monoamine Oxidase Inhibitors (MAOIs): Do not take Phenergan if you have used these antidepressants in the last two weeks.

If unsure, always consult your doctor or pharmacist. Also, notify your healthcare provider if you are using any of the following medications:

  • Anticholinergics: Often prescribed for conditions like irritable bowel syndrome, asthma, or a weak bladder. These may increase the risk of side effects like dizziness, dry mouth, and blurred vision.
  • Mental Health Medications: This includes antipsychotics (e.g., haloperidol, quetiapine) and antidepressants (e.g., amitriptyline, citalopram).
  • Sedatives or Relaxants: Such as diazepam or zolpidem, which are used to aid sleep or reduce anxiety.
  • Pain Management Medicines: Like aspirin, which is used for arthritis or joint pain. Phenergan may mask some of their side effects.
  • Antiarrhythmics: Medications like quinidine and amiodarone, used to manage irregular heartbeats.
  • Antiepileptics: Drugs used for controlling epilepsy or preventing seizures.
  • Antimicrobials: Such as erythromycin and levofloxacin, which are used to treat infections.

Discussing all current medications with your healthcare provider is crucial to prevent potential adverse interactions.

Phenergan FAQs

What is Phenergan used for?

Phenergan is primarily used to treat allergy symptoms like itching, runny nose, and hives. It's also used to prevent motion sickness, treat nausea and vomiting, aid in sedation, and as a short-term treatment for insomnia.

How should Phenergan be taken?

Phenergan can be taken orally in the form of tablets or syrup. It's important to follow the dosage instructions provided by your healthcare provider or as indicated on the packaging.

Can children take Phenergan?

Phenergan should not be used in children under 6 years old due to the risk of severe breathing problems. For older children, the dosage will vary based on age and weight.

Are there any medications that should not be taken with Phenergan?

Yes, Phenergan should not be taken with monoamine oxidase inhibitors (MAOIs), a type of antidepressant, or other medications that cause drowsiness unless directed by a doctor.

What are the common side effects of Phenergan?

Common side effects include drowsiness, dizziness, dry mouth, blurred vision, and constipation. If any of these effects persist or worsen, contact your healthcare provider.

Can Phenergan be used during pregnancy?

Phenergan should only be used during pregnancy if clearly needed and directed by a healthcare provider. Discuss all potential risks and benefits with your doctor.

Is it safe to drive or operate machinery after taking Phenergan?

Since Phenergan can cause drowsiness and dizziness, it's advised to avoid driving or operating machinery until you know how the medication affects you.

What should I do if I miss a dose of Phenergan?

If you miss a dose, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double the dose to catch up.

Can Phenergan cause allergic reactions?

Yes, Phenergan can cause serious allergic reactions, with symptoms including rashes, itching, difficulty breathing, and swelling of the face, lips, throat, or tongue. Seek immediate medical attention if you experience these symptoms.

Download patient leaflet

https://www.medicines.org.uk/emc/files/pil.5588.pdf

Checked By
Dr Sarah Thornton
MbChB, Coaching Academy diploma with distinction

Medical coaching


Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Independent prescriber, Superintendent pharmacist.


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