How long do the side effects of Mounjaro last?

If you’re considering starting or have recently started using Mounjaro (tirzepatide), you might be wondering about possible side effects, especially how long they might last. As with many medications, Mounjaro can cause a range of side effects. Knowing what to expect can help you feel more comfortable and prepared. In this article, we’ll cover the following points;

Medical Mojo offers a range of resources and access to weight loss medications like Mounjaro. Understanding the timeline of side effects can help you make informed decisions about your health.

Common side effects of Mounjaro

When you first start taking Mounjaro, you might experience some mild side effects as your body adjusts to the medication. Some of the most frequently reported ones include:

• Loss of appetite (that’s why you’re taking it after all!)
• Burping (yes you can expect to feel a bit windy)
• Nausea and sometimes vomiting
• Diarrhoea or constipation
• Hair loss
• Dizziness
• Abdominal discomfort
• Low blood pressure
• Lethargy
• Malaise (feeling generally unwell)

These side effects are usually temporary, and more often than not will last only a few days to a few weeks.As your body gets used to the medication, these symptoms usually fade. If this is not the case or if they worsen, contact your doctor or pharmacist for advice.

Serious side effects and long-term risks

While rare, Mounjaro does come with potential for serious side effects, some of which may last longer or require additional treatment. These include:

• Allergic Reactions. If you are allergic to any of the components of Mounjaro, reactions are likely to develop within hours of taking your first or second dose. These reactions can be mild and can include itching of the skin and an itchy rash. Very rarely, more severe reactions can develop. These manifest with swelling of the eyes, lips, mouth or throat, a severe rash and difficulty breathing. Reactions such as this are a medical emergency and need immediate treatment, so if there is any suspicion at all that this is occurring, call 999.
• Pancreatitis: Inflammation of the pancreas (pancreatitis) is a potentially life-threatening side effect. Symptoms include very severe upper abdominal pain radiating through to the back, which often feels worse after eating. If you suspect pancreatitis, get in touch with your healthcare provider immediately. If you have a history of pancreatitis you should check with your doctor before commencing treatment with Mounjaro.
• Gallbladder Issues: Mounjaro has been linked to gallstones and bile duct blockage. Signs to watch for include intense abdominal pain usually in the upper right side of the abdomen with radiation round to the back, jaundice (yellowing of the skin or eyes), and pale stools. Again, if any of these occur you should seek urgent medical attention.
• Severe Gastrointestinal Issues: If severe or ongoing, nausea, vomiting, and diarrhoea can lead to dehydration, and sometimes this can put an excessive strain on the kidneys and cause a rapid decline in kidney function (known as acute kidney injury). So, if you experience these symptoms, especially along with reduced urination or confusion, seek medical advice promptly.
• Thyroid Cancer Risk: In animal studies, Mounjaro has been linked with medullary thyroid cancer. Whilst it is not yet clear if this risk is also applicable to humans, it’s crucial to be aware and to report any neck lumps, difficulty swallowing, or changes in your voice to your doctor. If you have a history of, or a family history of thyroid cancers you should not take Mounjaro.

So how long do Mounjaro side effects last?

• Mild side effects like nausea or appetite changes are often short-lived and might disappear within a few days to weeks as your body adjusts.
• – Some gastrointestinal issues may last longer if they’re more intense or if they lead to complications like dehydration.
• – Serious side effects such as gallbladder problems or pancreatitis need immediate medical attention and could lead to lasting health changes.
• – Long-term risks like thyroid cancer may not present symptoms immediately, but it’s something your doctor will want to monitor if you’re on Mounjaro for an extended period.

As with many things in life, the duration of side effects varies from person to person. Some people might have no side effects at all, others only experience mild, short-lived symptoms, while others may have side effects that require ongoing management.

Final thoughts on Mounjaro side effects

Starting a new medication like Mounjaro can be an adjustment, but understanding the potential side effects and their duration can make the process smoother. Most mild side effects will go away as your body adapts, but serious ones or any that continue for more than a few days should be addressed immediately.

Disclaimer: This article is for informational purposes only and does not replace professional medical advice.

References:

1. British National Formulary (BNF). (n.d.) Tirzepatide – Side Effects. Available at: https://bnf.nice.org.uk/drugs/tirzepatide/#side-effects (Accessed: 3 November 2024).
2. Jensen, T.L., Brønden, A., Karstoft, K., Sonne, D.P. and Christensen, M.B., 2024. The Body weight Reducing Effects of Tirzepatide in People with and without Type 2 Diabetes: A Review on Efficacy and Adverse Effects. Patient preference and adherence, pp.373-382.
3. Parkman, H.P., Rim, D.S., Anolik, J.R., Dadparvar, S. and Maurer, A.H., 2024. Glucagonlike peptide-1 receptor agonists: the good, the bad, and the ugly—benefits for glucose control and weight loss with side effects of delaying gastric emptying. Journal of Nuclear Medicine Technology, 52(1), pp.3-7.
4. Long, B., Pelletier, J., Koyfman, A. and Bridwell, R.E., 2024. GLP-1 agonists: a review for emergency clinicians. The American Journal of Emergency Medicine.
5. Camilleri, M. and Lupianez-Merly, C., 2022. Effects of GLP-1 and other gut hormone receptors on the gastrointestinal tract and implications in clinical practice. Official journal of the American College of Gastroenterology| ACG, pp.10-14309.
6. Chen, W., Cai, P., Zou, W. and Fu, Z., 2024. Psychiatric adverse events associated with GLP-1 receptor agonists: a real-world pharmacovigilance study based on the FDA Adverse Event Reporting System database. Frontiers in Endocrinology, 15, p.1330936.