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Mounjaro 2.5mg Injection

from£145.99

Mounjaro 2.5mg is a highly effective medication designed to aid weight loss and manage blood sugar levels in adults with obesity or type 2 diabetes. Containing the active ingredient tirzepatide, Mounjaro 2.5mg works by activating GLP-1 and GIP receptors, which regulate appetite and increase feelings of fullness. Administered as a once-weekly subcutaneous injection, Mounjaro 2.5mg is most effective when combined with a healthy diet and regular exercise.

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Description

Mounjaro is a weight loss treatment available as a pre-filled pen for once-weekly injections. It is the UK-licensed version of the US-approved weight loss injection, Zepbound.

The active ingredient in Mounjaro is Tirzepatide, which binds to the receptors of two hormones, GIP and GLP-1. These hormones are naturally produced by your body in response to eating. By attaching to these receptors, Tirzepatide mimics the actions of GIP and GLP-1, signaling your body to increase insulin release from the pancreas. This helps control blood sugar levels and sends signals of fullness to the brain, reducing appetite and preventing cravings, ultimately aiding in weight loss.

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Overview

Active ingredients

What is it for?

How does it work?

How do you use it?

Warnings and precautions

Side effects

Drug interactions

FAQs

Download patent leaflet

Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Independent prescriber, Superintendent pharmacist.


Checked By
Dr Sarah Thornton
MbChB, Coaching Academy diploma with distinction

Medical coaching


What is Mounjaro 2.5mg injection?

Mounjaro is a weight loss treatment available as a pre-filled pen for once-weekly injections. It is the UK-licensed version of the US-approved weight loss injection, Zepbound.

The active ingredient in Mounjaro is Tirzepatide, which binds to the receptors of two hormones, GIP and GLP-1. These hormones are naturally produced by your body in response to eating. By attaching to these receptors, Tirzepatide mimics the actions of GIP and GLP-1, signaling your body to increase insulin release from the pancreas. This helps control blood sugar levels and sends signals of fullness to the brain, reducing appetite and preventing cravings, ultimately aiding in weight loss.

What is the active ingredient in Mounjaro 2.5mg injection?

The active ingredient in Mounjaro 2.5mg injection is Tirzepatide 2.5mg.  

What is Mounajro 2.5mg injection used for?

For weight loss, Mounjaro is also used along with a reduced-calorie diet and increased physical activity in adults who:
  • Have a BMI of 30 kg/m² or greater (obesity), or
  • Have a BMI between 27 kg/m² and 30 kg/m² (overweight) and have weight-related health problems (such as prediabetes, type 2 diabetes, high blood pressure, abnormal blood fat levels, obstructive sleep apnea, or a history of heart attack, stroke, or blood vessel problems).
BMI (Body Mass Index) measures your weight in relation to your height.

How does Mounajro 2.5mg injection work? 

Mounjaro contains the active ingredient Tirzepatide, which is a GIP analogue that activates both GLP-1 and GIP receptors. These hormones are naturally released from the gut after eating and help regulate blood sugar levels. GLP-1 and GIP also signal the brain to indicate fullness, reducing appetite and preventing cravings, and even slowing down stomach emptying. By combining regular Mounjaro injections with a reduced-calorie diet, many patients find they are better equipped to lose excess weight and control their appetite.

How do you use Mounjaro 2.5mg injection?

Always use this medicine exactly as your doctor or pharmacist has instructed. If you are unsure, check with your doctor or pharmacist. Each KwikPen contains 4 doses of Mounjaro, available in 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, or 15 mg. How Much to Use:
  • The starting dose is 2.5 mg once a week for four weeks. After four weeks, your doctor will increase your dose to 5 mg once a week.
  • Your doctor may increase your dose by 2.5 mg increments to 7.5 mg, 10 mg, 12.5 mg, or 15 mg once a week if needed. Your doctor will instruct you to stay on each dose for at least 4 weeks before increasing to a higher dose.
It's important to note that everyone is different, and there is no rush to increase your dose. You can stay at a dose for an extra month or two, or even permanently, if you prefer. If you need to decrease the dose due to side effects or if you're not tolerating a higher dose well, that's perfectly fine. Only increase your dose if you are tolerating your current dose well (i.e., no side effects) and wish to enhance your weight loss. If you're satisfied with your weight loss and not experiencing side effects, you can maintain your current dose for as long as necessary. Typically, maintenance doses are 5mg, 10mg, or 15mg. If you experience side effects, consider staying at your current dose or reducing it. Speak to our clinical team for further advice. Choosing When to Administer Mounjaro:
  • You can use your pen at any time of the day, with or without meals. Try to use it on the same day each week. To help you remember, you may want to mark the day on a calendar or use the “Instructions for Use” to tick off the day of the week when you inject your first dose.
  • If necessary, you can change the day of your weekly Mounjaro injection, as long as it has been at least 3 days since your last injection. After selecting a new dosing day, continue with once-a-week dosing on that new day.
How to Inject Mounjaro KwikPen:
  • Mounjaro is injected under the skin (subcutaneous injection) of your stomach area (abdomen), upper leg (thigh), or upper arm. You may need help from someone else if you choose to inject in your upper arm.
  • You can use the same area of your body each week, but be sure to choose a different injection site within that area each time. If you also inject insulin, choose a different injection site for the insulin.
  • To inject Mounjaro, follow these steps to take your dose:
    1. Familiarize yourself with the complete guide that comes with the pen.
    2. Remove the pen from the packaging and check the expiration date.
    3. Ensure you have a clean, dry area of skin on your stomach, thigh, or upper arm.
    4. Remove the cap from the pen and clean the injection site with an alcohol swab.
    5. Select a new pen needle. Always use a new needle for each injection to prevent infections and blockages.
    6. Attach the needle to the pen by pushing it straight on and twisting until tight.
    7. Remove the outer needle shield and keep it for later use.
    8. Hold the pen at a 90-degree angle against your skin and press the button on top to release the needle.
    9. Hold the pen in place for at least 5 seconds, then release the button to retract the needle.
    10. Dispose of the used pen and needle in a sharps container or follow your healthcare professional's disposal instructions.
    Mounjaro is taken weekly. Ensure you take it at the same time each week and rotate injection sites to prevent skin irritation.

Who should not take Mounjaro 2.5mg injection?

Do not use Mounjaro KwikPen:
  • If you are allergic to tirzepatide or any other ingredients in this medicine, check the product information leaflet below.
Warnings and Precautions: Talk to your doctor, pharmacist, or nurse before using Mounjaro if:
  • You have severe digestion problems or delayed stomach emptying (including severe gastroparesis).
  • You have ever had pancreatitis (inflammation of the pancreas causing severe, persistent stomach and back pain).
  • You have eye problems (such as diabetic retinopathy or macular edema).
  • You are using a sulfonylurea (another diabetes medicine) or insulin, as Mounjaro can cause low blood sugar (hypoglycemia). Your doctor may need to adjust your doses of these medications to reduce this risk.
When starting treatment with Mounjaro, you might experience dehydration due to vomiting, nausea, and/or diarrhea, which can affect kidney function. It is important to drink plenty of fluids to avoid dehydration. Contact your doctor if you have any concerns. Children and Adolescents: This medicine should not be given to children and adolescents under 18 years of age as it has not been studied in this age group. Pregnancy: This medicine should not be used during pregnancy as its effects on an unborn child are unknown. If you are pregnant, think you may be pregnant, or are planning to have a baby, consult your doctor before using this medicine. It is recommended to use contraception while using Mounjaro. If you are a woman with obesity or overweight and using oral contraceptives, consider also using a barrier method (e.g., a condom) or switching to a non-oral contraceptive method for 4 weeks after starting Mounjaro and for 4 weeks after each dose increase. Breast-feeding: It is unknown whether tirzepatide passes into breast milk. A risk to newborns/infants cannot be ruled out. If you are breast-feeding or planning to breast-feed, consult your doctor before using this medicine. You and your doctor should decide whether to stop breast-feeding or delay using Mounjaro. Driving and Using Machines: It is unlikely that this medicine will affect your ability to drive and use machines. However, if you use Mounjaro in combination with a sulfonylurea or insulin, low blood sugar (hypoglycemia) may occur, which can reduce your ability to concentrate. Avoid driving or using machines if you experience any signs of low blood sugar, such as headache, drowsiness, weakness, dizziness, hunger, confusion, irritability, fast heartbeat, and sweating. Refer to section 4 for more details. For information on the increased risk of low blood sugar, see section 2, ‘Warnings and Precautions.’ Consult your doctor for further information. Mounjaro KwikPen Contains Sodium: This medicine contains less than 1 mmol sodium (23 mg) per dose, essentially making it ‘sodium-free.’ Mounjaro KwikPen Contains Benzyl Alcohol: Each multiple-dose pre-filled pen contains 5.4 mg benzyl alcohol [E1519] in each 0.6 ml dose. Benzyl alcohol may cause allergic reactions. Consult your doctor or pharmacist for advice if you have liver or kidney disease, as large amounts of benzyl alcohol can build up in your body and may cause side effects (called “metabolic acidosis”).

What are the side effects with Mounjaro 2.5mg injection?

Like all medicines, this medication can cause side effects, although not everyone will experience them. Serious Side Effects Uncommon (may affect up to 1 in 100 people):
  • Inflamed pancreas (acute pancreatitis): This can cause severe pain in the stomach and back that does not go away. Seek immediate medical attention if you experience these symptoms.
Rare (may affect up to 1 in 1,000 people):
  • Severe allergic reactions (e.g., anaphylactic reaction, angioedema): Seek immediate medical help and inform your doctor if you experience symptoms such as breathing problems, rapid swelling of the lips, tongue, and/or throat with difficulty swallowing, and a fast heartbeat.
Other Side Effects Very Common (may affect more than 1 in 10 people):
  • Low blood sugar (hypoglycemia) when tirzepatide is used for the treatment of type 2 diabetes with medicines that contain a sulfonylurea and/or insulin: If you are using a sulfonylurea or insulin, the dose may need to be lowered while you use tirzepatide. Symptoms of low blood sugar may include headache, drowsiness, weakness, dizziness, hunger, confusion, irritability, fast heartbeat, and sweating. Your doctor should tell you how to treat low blood sugar.
  • Feeling sick (nausea)
Other Side Effects Very Common (may affect more than 1 in 10 people):
  • Diarrhea
  • Vomiting (usually goes away over time)
  • Constipation
These side effects are usually not severe and are most common when first starting tirzepatide but tend to decrease over time in most patients. Constipation and vomiting are very common when used for weight management, but common when used for type 2 diabetes. Common (may affect up to 1 in 10 people):
  • Low blood sugar (hypoglycemia) when tirzepatide is used for type 2 diabetes with both metformin and a sodium-glucose co-transporter 2 inhibitor (another diabetes medicine): Symptoms may include headache, drowsiness, weakness, dizziness, hunger, confusion, irritability, fast heartbeat, and sweating. Your doctor should tell you how to treat low blood sugar.
  • Allergic reaction (hypersensitivity): Symptoms may include rash, itching, and eczema.
  • Dizziness observed in patients treated for weight management.
  • Low blood pressure observed in patients treated for weight management.
  • Decreased appetite observed in patients treated for type 2 diabetes.
  • Stomach (abdominal) pain
  • Indigestion (dyspepsia)
  • Stomach bloating
  • Burping (eructation)
  • Gas (flatulence)
  • Reflux or heartburn (gastroesophageal reflux disease – GORD): A condition caused by stomach acid coming up into the tube from your stomach to your mouth.
  • Hair loss observed in patients treated for weight management.
  • Feeling tired (fatigue)
  • Injection site reactions: Such as itching or redness.
  • Fast pulse: Common when used for type 2 diabetes and uncommon when used for weight management.
  • Increased levels of pancreatic enzymes (such as lipase and amylase) in blood: Increased levels of amylase is uncommon in weight management.
Uncommon (may affect up to 1 in 100 people):
  • Low blood sugar (hypoglycemia) when tirzepatide is used with metformin for type 2 diabetes: Symptoms may include headache, drowsiness, weakness, dizziness, hunger, confusion, irritability, fast heartbeat, and sweating. Your doctor should tell you how to treat low blood sugar.
  • Gallstones
  • Weight loss observed in patients treated for type 2 diabetes
  • Injection site pain
  • Increased calcitonin levels in blood
  • Cholecystitis (infection of the gallbladder) observed in patients treated for weight management.
Reporting of Side Effects: If you experience any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects, you can help provide more information on the safety of this medicine.

Does Mounjaro 2.5mg interact with any other medicines?

Tirzepatide can slow down stomach emptying, which may impact how other oral medications are absorbed. This is most noticeable when you first start taking tirzepatide. Paracetamol:
  • When taken with tirzepatide, the peak concentration (Cmax) of paracetamol is reduced by 50%, and it takes an additional hour to reach this peak (tmax).
  • No dose adjustment for paracetamol is needed.
  • The effect on paracetamol absorption is dose-dependent. Lower doses of tirzepatide (0.5 and 1.5 mg) only slightly change paracetamol levels. After four weekly doses of tirzepatide (5/5/8/10 mg), there is no effect on paracetamol Cmax and tmax, and overall exposure (AUC) remains unchanged.
Oral Contraceptives:
  • A single 5 mg dose of tirzepatide can reduce the Cmax and AUC of oral contraceptives, delaying their peak levels.
    • Ethinyl estradiol: Cmax reduced by 59%, AUC by 20%, with a delay in tmax of 4 hours.
    • Norelgestromin: Cmax reduced by 55%, AUC by 23%, with a delay in tmax of 4.5 hours.
    • Norgestimate: Cmax reduced by 66%, AUC by 20%, with a delay in tmax of 2.5 hours.
  • These changes are not considered clinically significant, so no dose adjustment is needed for women with a normal BMI.
Special Considerations for Oral Contraceptives in Overweight or Obese Women:
  • There is limited data on how tirzepatide affects oral contraceptives in overweight or obese women. Reduced effectiveness cannot be ruled out.
  • It is recommended to switch to a non-oral contraceptive method or add a barrier method of contraception for 4 weeks when starting tirzepatide and after each dose increase.

Mounjaro 2.5mg FAQs

 

What is Mounjaro 2.5mg used for?

Mounjaro 2.5mg is used to aid weight loss and help manage blood sugar levels in adults with obesity or type 2 diabetes. It works best when combined with a healthy diet and regular exercise.

How does Mounjaro 2.5mg work?

Mounjaro 2.5mg contains tirzepatide, which activates GLP-1 and GIP receptors in the body. These hormones help regulate appetite and blood sugar levels by increasing feelings of fullness, reducing hunger, and slowing stomach emptying.

How long does it take for Mounjaro 2.5mg to work?

Initial weight loss can be seen as early as 4 weeks after starting Mounjaro 2.5mg, with patients losing around 5 lbs (2 kg). Continued weight loss has been observed over 40 weeks, with an average loss of 25 lbs (11.3 kg) at higher doses.

Is Mounjaro 2.5mg effective for weight loss?

Yes, Mounjaro 2.5mg has been shown to be effective in several clinical trials. In the SURPASS-2 trial, patients on higher doses of Mounjaro experienced significant weight loss, averaging 11% or 25 lbs over 40 weeks.

How do I take Mounjaro 2.5mg?

Mounjaro 2.5mg is administered as a subcutaneous injection once a week. Your healthcare provider will show you how to use the prefilled KwikPen for the injection.

Can I drink alcohol while using Mounjaro 2.5mg?

There are no known interactions between Mounjaro 2.5mg and alcohol. However, alcohol can affect blood sugar levels and add significant calories. Consult with your healthcare provider before consuming alcohol while using Mounjaro.

Do I need a prescription for Mounjaro 2.5mg?

Yes, a prescription is required for Mounjaro 2.5mg. You must complete a health consultation with a healthcare provider to determine if Mounjaro is suitable for you.

Is Mounjaro 2.5mg safe?

Mounjaro 2.5mg has been approved by the FDA in the US and the MHRA in the UK, with extensive literature supporting its safety and effectiveness. Common side effects include nausea and diarrhea.

Can I use Mounjaro 2.5mg if I am pregnant or breastfeeding?

Mounjaro 2.5mg is not recommended during pregnancy or breastfeeding as its effects on the unborn child and breast milk are unknown. Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Where can I buy Mounjaro 2.5mg in the UK?

You can buy Mounjaro 2.5mg from a registered pharmacy with a prescription. Alternatively, you can purchase it online from medicalmojo.co.uk after completing a health consultation. Approved treatments are delivered securely and discreetly.

Is Mounjaro 2.5mg addictive?

No, Mounjaro 2.5mg is not addictive. The active ingredient, tirzepatide, helps regulate appetite and blood sugar levels and does not cause addiction or dependence.

Is Mounjaro 2.5mg available in generic form?

No, there is currently no generic version of Mounjaro available.

Does Mounjaro 2.5mg affect oral contraceptives?

If you are a woman who is overweight or has obesity and uses oral contraceptives, consider also using a barrier method of contraception (e.g., a condom) or switching to a non-oral contraceptive method for 4 weeks after starting Mounjaro and for 4 weeks after each dose increase.

How long does Mounjaro take to work?

Data suggests that initial weight loss with Mounjaro can be seen as early as 4 weeks after starting, with an average loss of around 5 lbs (2 kg). Patients continued to experience weight loss until the study concluded at around 40 weeks, with those on the optimal dose losing an average of 25 lbs (11.3 kg).

How effective is the Mounjaro jab?

Mounjaro is highly effective in helping overweight and obese patients lose weight, as demonstrated in several clinical trials. In the 40-week SURPASS-2 trial involving 1,879 adult patients, those on the optimal 15 mg dose of Mounjaro experienced an average weight loss of 11% or 25 lbs. Patients sustained weight reductions throughout the 40 weeks.

Which is better: Mounjaro or Ozempic?

SURPASS-2 compared Mounjaro at doses of 5 mg, 10 mg, and 15 mg to once-weekly Ozempic 1 mg injections. Mounjaro at doses of 10 mg and 15 mg resulted in significantly better weight loss than Ozempic 1 mg.

Is Mounjaro safe?

Mounjaro has been approved for use by both the American FDA and the UK MHRA, with extensive literature supporting its safety and effectiveness. The most common side effects are nausea and diarrhea.    

Download patient leaflet

https://www.medicines.org.uk/emc/files/pil.15481.pdf

Checked By
Dr Sarah Thornton
MbChB, Coaching Academy diploma with distinction

Medical coaching


Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Independent prescriber, Superintendent pharmacist.


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