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Caverject 10mcg/ml dual chamber injection

from£42.99

Caverject is an injection treatment for men with erectile dysfunction. Unlike ED tablets like Viagra and Cialis, Caverject is injected directly into the penis, making it a viable option for men who haven’t had success with oral medications or who cannot take them for medical reasons. Caverject is available in two forms: the regular Caverject (sometimes called Caverject Vials) and the Caverject Dual Chamber (or Caverject Impulse). The regular Caverject comes as a powder and liquid solution that must be mixed manually, while the Dual Chamber version contains both components within the injection device, making it easier to mix by simply twisting the plunger.

Caverject contains prostaglandin E1, a drug that relaxes blood vessels and enhances blood flow to the penis, helping to achieve and maintain erections.

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Overview

Active ingredients

What is it for?

How does it work?

How do you use it?

Warnings and precautions

Side effects

Drug interactions

FAQs

Download patent leaflet

Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Independent prescriber, Superintendent pharmacist.


Checked By
Dr Sarah Thornton
MbChB, Coaching Academy diploma with distinction

Medical coaching


What is Caverject Dual Chamber10mcg/ml

Caverject Dual Chamber 10mcg is a highly effective injectable treatment for erectile dysfunction (ED) in men. This medication is designed for those who have not responded well to oral ED treatments or for whom such treatments are unsuitable. Caverject Dual Chamber provides a convenient and easy-to-use solution that combines both powder and solvent in a single dual-chamber syringe, simplifying the preparation process and ensuring accurate dosing.

What is the active ingredient in Caverject Dual Chamber 10mcg/ml injection?

The active ingredient in Caverject Dual Chamber 10mcg/ml is Alprostadil.  

What is Caverject Dual Chamber 10mcg/ml used for?

Caverject Dual Chamber 10mcg/ml is indicated for:
  • Men with erectile dysfunction (ED), particularly those who have not responded to oral ED treatments such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra).
  • Men who cannot take oral ED medications due to contraindications or side effects.

How does Caverject Dual Chamber 10mcg/ml work?

Caverject is administered via injection directly into the corpus cavernosum of the penis. This localized delivery allows the medication to act directly at the site of action, bypassing the gastrointestinal tract and reducing the potential for systemic side effects. Alprostadil induces an erection by relaxing the trabecular smooth muscle and dilating the cavernosal arteries, resulting in enhanced blood flow and entrapment within the erectile tissue.

How do you use Caverject Dual 10mcg/ml injection?

Your first use of Caverject Dual Chamber 10mcg/ml injection should be demonstrated by a nurse or doctor. Do not attempt to use it on your own without proper guidance. The following instructions provide an overview of the application process, but they are not exhaustive. Always follow the instructions provided in the leaflet and those given by your clinician. Instructions for Caverject Dual Chamber 10mcg/ml injection: The injection and solution are contained within the syringe of the Caverject Dual Chamber, so you don’t need to manually mix them.
  1. Take out one injection device and needle.
  2. Fix the needle to the device and turn it clockwise until it’s firmly attached.
  3. Remove the outer protective cap.
  4. Holding the device pointing upwards, with the plunger rod fully extended, twist the plunger rod to mix the powder and solution together.
  5. Gently shake to dissolve the powder.
  6. Remove the inner needle cap. If the needle is bent, do not use it and replace it with another one.
  7. Flick the syringe to remove any bubbles.
  8. Fully turn the plunger rod as far as it will go and then push it in.
  9. Turn the plunger rod to set the recommended dose.
You then have 24 hours to use the injection. How to Inject Caverject
  1. Tap the syringe to remove any air bubbles.
  2. Set the dose your prescriber has recommended by pushing the plunger to the correct amount.
  3. Ensure the needle is straight. If it’s bent, attach a new one.
  4. Hold your penis with your fingers underneath and thumb on top, gently applying pressure to make the injection site at the base of the penis bulge out.
  5. Maintain a firm grip and insert the needle into the penis, avoiding any veins or blood vessels.
  6. Push the plunger to deliver the dose.
  7. If the liquid doesn’t flow easily, don’t force it. Move the needle slightly and try again.
  8. Once the dose is delivered, remove the needle from your penis and gently apply a gauze pad to the injection site. Discard any remaining mixture.
Your clinician will demonstrate how to use and mix Caverject.

Who should not use the Caverject 10mcg/ml Dual Chamber injection?

  • Do not use Caverject if you have conditions that predispose you to priapism (prolonged erection) such as sickle cell anemia, multiple myeloma, or leukemia.
  • Avoid using Caverject if you have penile implants or deformities.
  • Discuss your full medical history with your healthcare provider, particularly if you have cardiovascular conditions, as sexual activity may pose a risk.
  • Use Caverject cautiously if you are taking anticoagulants or have a bleeding disorder.

What are the side effects with Caverject 10mcg/ml Dual Chamber injection?

Caverject (alprostadil) 10mcg/mL, like all medications, can cause side effects. Some of the common and serious side effects include:

Common Side Effects:

  1. Penile Pain: Pain in the penis, urethra, or testicles is the most commonly reported side effect.
  2. Prolonged Erection: Erections lasting longer than usual, but less than 4 hours.
  3. Bruising: Mild bruising at the injection site.
  4. Bleeding: Light bleeding at the injection site.
  5. Swelling: Mild swelling or lumps at the injection site.
  6. Headache: Mild to moderate headache.
  7. Dizziness: Feeling lightheaded or dizzy.

Serious Side Effects:

  1. Priapism: A prolonged erection lasting more than 4 hours, which requires immediate medical attention to prevent permanent damage.
  2. Severe Pain: Intense pain in the penis, urethra, or testicles.
  3. Scarring or Fibrosis: Formation of fibrous tissue inside the penis, potentially leading to curvature or deformity.
  4. Infection: Signs of infection at the injection site, such as redness, swelling, warmth, or discharge.
  5. Hematoma: A significant collection of blood outside the blood vessels causing a large bruise or lump.

Rare Side Effects:

  1. Low Blood Pressure: Sudden drop in blood pressure, leading to fainting or dizziness.
  2. Rapid Heart Rate: Palpitations or unusually fast heartbeat.
  3. Allergic Reactions: Symptoms such as rash, itching, swelling, severe dizziness, or trouble breathing.
  4. Injection Site Reactions: Severe reactions such as intense pain, severe swelling, or significant bruising.

Precautions:

  • Monitor for Side Effects: Regularly check for any signs of side effects and report them to your healthcare provider.
  • Seek Immediate Help: If you experience a prolonged erection (priapism) or signs of a severe allergic reaction, seek immediate medical attention.
It's important to follow the instructions provided by your healthcare provider and the information in the patient leaflet to minimize the risk of side effects. If you have any concerns or experience unusual symptoms, contact your healthcare provider promptly.

Does Caverject 10mcg/ml Dual Chamber injection interact with any other medicines?

Caverject (alprostadil) 10mcg/mL may interact with other medications, which can affect how it works or increase the risk of side effects. It's important to inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medicines, and herbal supplements. Some of the key drug interactions include:

1. Blood Pressure Medications:

  • Antihypertensives: Medications used to treat high blood pressure can enhance the hypotensive effects of Caverject, leading to a significant drop in blood pressure. This can cause dizziness, lightheadedness, or fainting.

2. Blood Thinners:

  • Anticoagulants and Antiplatelets: Drugs such as warfarin, heparin, and aspirin can increase the risk of bleeding at the injection site.

3. Other Erectile Dysfunction Treatments:

  • PDE5 Inhibitors: Medications like sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra) can have additive effects when used with Caverject, increasing the risk of prolonged erections (priapism) and other side effects.

4. Vasodilators:

  • Nitrates and Nitroglycerin: These medications, often used to treat angina and other heart conditions, can significantly lower blood pressure when used with Caverject.

5. Alpha-Blockers:

  • Medications for Enlarged Prostate or High Blood Pressure: Drugs such as tamsulosin (Flomax) and doxazosin (Cardura) can enhance the blood pressure-lowering effects of Caverject.

6. Psychotropic Drugs:

  • Antidepressants and Antipsychotics: Some medications used to treat mental health conditions can interact with Caverject, potentially increasing side effects or altering its effectiveness.

7. Sympathomimetic Agents:

  • Drugs like Epinephrine: These medications can interact with Caverject, potentially leading to adverse cardiovascular effects.

8. Other Injectable Medications:

  • Penile Implants or Injections: Combining Caverject with other injectable treatments for erectile dysfunction can increase the risk of priapism and other serious side effects.

Precautions:

  • Inform Your Doctor: Always inform your healthcare provider about all the medications and supplements you are taking before starting Caverject.
  • Monitor for Side Effects: Be vigilant about any unusual symptoms or side effects and report them to your healthcare provider immediately.
By keeping your healthcare provider informed and following their guidance, you can minimize the risk of adverse interactions and ensure the safe use of Caverject.

FAQs

Is using Caverject 10mcg/ml Dual Chamber injection painful?

Using Caverject 10mcg can cause some discomfort or pain at the injection site for some men. This is a common side effect and can vary in intensity from mild to moderate. The pain is typically brief and may decrease with regular use as you become more accustomed to the injection process. If you experience significant pain or persistent discomfort, it is important to discuss this with your healthcare provider, as they may adjust your dosage or injection technique to improve your experience.

How does Caverject 10mcg/ml Dual Chamber injection work?

Caverject 10mcg/ml works by using a medication called alprostadil, which is a synthetic version of a naturally occurring substance called prostaglandin E1. Alprostadil helps to relax the smooth muscle and dilate the blood vessels in the penis. This process increases blood flow to the penis, leading to an erection. Here's how it works in detail:
  1. Injection: Caverject is injected directly into the corpus cavernosum, which is one of the two cylindrical chambers in the penis that fill with blood to create an erection.
  2. Relaxation of Smooth Muscle: Alprostadil relaxes the smooth muscle tissue in the corpus cavernosum.
  3. Dilation of Blood Vessels: The relaxation of smooth muscle tissue causes the blood vessels to dilate, allowing more blood to flow into the penis.
  4. Increased Blood Flow: The increased blood flow fills the corpus cavernosum, leading to an erection.
Caverject is typically effective within 5 to 20 minutes after injection, and the erection can last for about 30 to 60 minutes. It is important to follow the prescribed dosage and instructions provided by your healthcare provider to ensure safe and effective use of the medication.

What is the difference between the Caverject injection and the Caverject Dual Chamber injection?

Caverject injections and Caverject Dual Chamber injections are both used for treating erectile dysfunction, but they differ in their preparation and convenience. Standard Caverject injections require manual mixing of a powder and a solution using separate vials and syringes, which can be time-consuming and requires careful handling. In contrast, Caverject Dual Chamber injections streamline this process by combining the powder and solution within a single syringe. This dual-chamber system simplifies preparation, as it only requires mixing by twisting the plunger rod, eliminating the need for separate vials and reducing the risk of preparation errors. This makes Caverject Dual Chamber a more user-friendly and convenient option for patients.

What is Caverject 10mcg/mL Dual Chamber Injection used for?

Caverject 10mcg/mL is used to treat erectile dysfunction (ED) in men. It helps achieve and maintain an erection by increasing blood flow to the penis.

How does Caverject 10mcg/mL Dual Chamber Injection work?

Caverject contains alprostadil, a medication that relaxes blood vessels and increases blood flow to the penis, helping to produce an erection.

How do I use Caverject 10mcg/mL Dual Chamber Injection?

Caverject is administered via injection into the base of the penis. Your healthcare provider will show you how to prepare and inject the medication properly.

How long does it take for Caverject to work?

Caverject typically starts working within 5 to 20 minutes after injection, with the erection lasting around 30 to 60 minutes.

What are the common side effects of Caverject 10mcg/mL Dual Chamber Injection?

Common side effects include pain at the injection site, bruising, prolonged erection (priapism), and minor bleeding. Serious side effects are rare but require immediate medical attention.

Can I use Caverject 10mcg/mL Dual Chamber injection with other ED medications?

No, you should not use Caverject in combination with other ED medications like sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra) without consulting your healthcare provider.

Are there any drug interactions with Caverject 10mcg/mL Dual Chamber injection?

Yes, Caverject can interact with medications for blood pressure, blood thinners, other ED treatments, and certain psychotropic drugs. Inform your doctor about all medications you are taking.

Who should not use Caverject 10mcg/mL Dual Chamber injection?

Caverject is not suitable for men with certain medical conditions such as severe cardiovascular diseases, penile deformities, or those advised to avoid sexual activity. Always consult your doctor before use.

How often can I use Caverject 10mcg/mL Dual Chamber injection?

You should not use Caverject more than three times a week, with at least 24 hours between each injection. Follow your healthcare provider's recommendations for usage.

What should I do if I experience a prolonged erection?

If you have an erection lasting more than 4 hours (priapism), seek immediate medical attention to prevent long-term damage to the penis.

Download patient leaflet

https://www.medicines.org.uk/emc/files/pil.6375.pdf

Checked By
Dr Sarah Thornton
MbChB, Coaching Academy diploma with distinction

Medical coaching


Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Independent prescriber, Superintendent pharmacist.


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