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Naproxen Gastro-Resistant Tablets 500mg

from£25.99

Naproxen belongs to a group of medications known as non-steroidal anti-inflammatory drugs (NSAIDs). It can relieve pain, stiffness, and inflammation caused by conditions such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis (arthritis of the spine and pelvis), and juvenile rheumatoid arthritis. Additionally, Naproxen is used to treat acute gout and acute musculoskeletal disorders, including sprains, strains, trauma, lower back pain, neck pain, and inflammation of tendons and muscles.

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Naproxen Gastro-Resistant Tablets 500mg
SKU: NAP500 Category: Tags: , ,

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1 x 56, 2 x 56

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Overview

Active ingredients

What is it for?

How does it work?

How do you use it?

Warnings and precautions

Side effects

Drug interactions

FAQs

Download patent leaflet

Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Independent prescriber, Superintendent pharmacist.


Checked By
Dr Sarah Thornton
MbChB, Coaching Academy diploma with distinction

Medical coaching


What is Naproxen?

Naproxen is a pain reliever that belongs to the class of drugs known as non-steroidal anti-inflammatory drugs (NSAIDs). This group also includes familiar medications like aspirin, ibuprofen, and diclofenac. Naproxen offers stronger anti-inflammatory effects compared to aspirin and ibuprofen and is considered comparable in strength to diclofenac, but with fewer associated risks and side effects.

Naproxen is effective for treating pain accompanied by inflammation, such as in cases of sprains or strains. It is also used to alleviate symptoms of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile arthritis. This medication can be prescribed to adults over 18 years old. Each box contains 56 tablets, available in strengths of either 250mg or 500mg.

It is important to take Naproxen with food to protect the stomach. For those using Naproxen long-term (for more than two weeks), it is advisable to take a stomach-protective treatment, such as Omeprazole, to minimize the risk of side effects.

What is the active ingredient in Naproxen 500mg gastro resistant tablets?

The active ingredient in Naproxen 500mg gastro resistant tablets is Naproxen 500mg.

What is Naproxen used for?

Naproxen, a non-steroidal anti-inflammatory drug (NSAID), is utilized to alleviate pain and inflammation in the body. It works by decreasing the hormones responsible for swelling. Naproxen is commonly prescribed for conditions such as muscle pain, rheumatoid arthritis, menstrual cramps, and gout.

How does Naproxen work?

This medication functions by inhibiting the activity of cyclooxygenase (COX) enzymes in the body. These enzymes are involved in the production of prostaglandins, chemicals that are generated at injury sites and contribute to pain and inflammation. By blocking COX enzymes, the production of prostaglandins is reduced, leading to a significant decrease in pain and inflammation. Consequently, this helps manage symptoms associated with various conditions such as arthritis, muscle pain, and other inflammatory disorders.

How to take Naproxen 500mg gastro resistant tablets?

Always take this medication exactly as your doctor has instructed. Consult your doctor or pharmacist if you are uncertain about the instructions. Use the lowest effective dose for the shortest possible duration. The recommended doses are as follows:
  • Rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis: 250-500mg taken every 12 hours.
  • Acute musculoskeletal disorders: Start with 500mg, then take 250mg every 6-8 hours as needed, not exceeding 1250mg in a 24-hour period.
  • Acute gout: Begin with 750mg, followed by 250mg every 8 hours until the attack subsides.
For elderly patients:
  • Elderly individuals are more prone to side effects. Therefore, treatment should begin with the lowest possible dose for the shortest duration. Your doctor will monitor your condition regularly.
If you have any questions about why you have been prescribed this medication, check with your doctor.
Use in Children: If Naproxen Tablets are prescribed for a child, ensure they are taken as directed by the doctor. Naproxen is not recommended for children under 16 years old, except for treating juvenile rheumatoid arthritis. For this condition, the dose is 10mg per kg of body weight per day, divided into two doses taken every 12 hours. It is important to stay well-hydrated while taking this medication, especially for individuals with kidney problems. If You Take More Naproxen Tablets Than You Should: If you accidentally take too many Naproxen Tablets, contact a doctor or go to a hospital immediately. Bring the medication pack with you. If You Forget to Take Naproxen Tablets: If you miss a dose, skip it and take your next dose at the usual time. Do not take a double dose to compensate for the missed one.
 

Who should not take Naproxen?

Do not take Naproxen Tablets if you:
  • Are allergic to naproxen or any other ingredients in this medicine (listed in section 6)
  • Have a peptic ulcer (ulcer in your stomach or duodenum) or stomach bleeding, or have had two or more episodes of peptic ulcers, stomach bleeding, or perforation
  • Have a history of stomach bleeding or perforation related to the use of NSAIDs (such as mefenamic acid, ibuprofen, diclofenac) or aspirin
  • Have a history of allergy to aspirin, ibuprofen, or NSAIDs, which includes asthma attacks, swelling of the nose and throat, skin rashes, or a runny nose
  • Suffer from severe kidney, heart, or liver disease
  • Are in the last trimester of your pregnancy
If you visit a hospital, doctor, or dentist, inform them that you are taking Naproxen Tablets. Do not take Naproxen Tablets if any of the above conditions apply to you. If you are unsure, consult your doctor or pharmacist before taking this medicine. Warnings and precautions: Consult your doctor, pharmacist, or nurse before taking Naproxen Tablets if you:
  • Suffer from asthma or allergies (like hay fever) or have had swelling of the face, lips, eyes, or tongue in the past
  • Feel weak (perhaps due to an illness) or are an older person
  • Have nasal polyps (lumps in your nose) or experience frequent sneezing, a runny, blocked, or itchy nose (rhinitis)
  • Have kidney or liver problems
  • Have issues with blood clotting
  • Have blood vessel (artery) problems anywhere in your body
  • Have high levels of fat (lipid) in your blood (hyperlipidemia)
  • Have an autoimmune condition such as systemic lupus erythematosus (SLE, which causes joint pain, skin rashes, and fever) or colitis or Crohn’s disease (conditions causing inflammation of the bowel, bowel pain, diarrhea, vomiting, and weight loss)
  • Have heart problems (high blood pressure, previous stroke)
Medications like naproxen may be associated with a small increased risk of heart attack (myocardial infarction) or stroke. This risk is more likely with high doses and prolonged treatment. Do not exceed the recommended dose or duration of treatment. If you have heart problems, a previous stroke, or think you might be at risk of these conditions (for example, if you have high blood pressure, diabetes, high cholesterol, or are a smoker), discuss your treatment with your doctor or pharmacist.

What are the side effects with Naproxen?

Like all medications, this medicine can cause side effects, although not everyone experiences them. Serious side effects: If you experience any of the following during your treatment, stop taking the medicine and seek immediate medical help: Serious stomach or gut problems, signs include:
  • Bleeding from the stomach, which may appear as vomit with blood in it or bits that look like coffee grounds.
  • Bleeding from the anus, which may present as passing black, sticky stools or bloody diarrhea.
  • Ulcers or holes in your stomach or gut, with symptoms such as an upset stomach, stomach pain, fever, nausea, or vomiting.
  • Problems with your pancreas, indicated by severe stomach pain that radiates to your back.
  • Worsening of ulcerative colitis or Crohn’s disease, with symptoms including pain, diarrhea, vomiting, and weight loss.
Allergic reactions, signs include:
  • Sudden swelling of the throat, face, hands, or feet.
  • Difficulty breathing, chest tightness.
  • Skin rashes, blisters, or itching.
Severe skin rashes, signs include:
  • A rapidly developing rash with blisters or peeling skin, possibly with blisters in your mouth, throat, or eyes. Fever, headache, cough, and body aches may accompany the rash.
  • Blistering of the skin when exposed to sunlight (porphyria cutanea tarda), typically seen on the arms, face, and hands.
Liver problems, signs include:
  • Yellowing of the skin or the whites of the eyes (jaundice).
  • Fatigue, loss of appetite, nausea, vomiting, and pale-colored stools (hepatitis), confirmed through blood tests.
Heart attack, signs include:
  • Chest pain that may radiate to your neck, shoulders, and down your left arm.
Stroke, signs include:
  • Muscle weakness and numbness, possibly only on one side of the body.
  • Sudden changes in sense of smell, taste, hearing, or vision, and confusion.
Meningitis, signs include:
  • Fever, nausea or vomiting, stiff neck, headache, sensitivity to bright light, and confusion (most likely in individuals with autoimmune conditions such as systemic lupus erythematosus).
Other possible side effects: Stomach and gut:
  • Heartburn, indigestion, stomach ache, nausea, vomiting, constipation, diarrhea, and gas.
Blood:
  • Blood disorders, such as anemia or changes in white blood cell counts.
Mental health:
  • Difficulty sleeping or changes in dreaming patterns.
  • Depression.
  • Confusion or experiencing hallucinations (seeing or hearing things that aren't there).
Nervous system:
  • Headache.
  • Seizures, dizziness, light-headedness, or drowsiness.
  • Pins and needles or numbness in your hands and feet.
  • Difficulty with memory or concentration.
Eyes and ears:
  • Changes in vision or eye pain.
  • Hearing changes, including ringing in the ears (tinnitus) and hearing loss.
  • Dizziness affecting balance.
Heart and circulation:
  • Swelling of hands, feet, or legs (edema), possibly accompanied by chest pains, tiredness, and shortness of breath (heart failure).
  • Palpitations, slow heartbeat, or high blood pressure.
  • Issues with heart function or blood vessels, indicated by tiredness, shortness of breath, feeling faint, and general pain.
Chest:
  • Difficulty breathing, including shortness of breath, wheezing, or coughing.
  • Pneumonia or lung inflammation.
Skin and hair:
  • Skin rashes, including redness, hives, pimples, and blisters on the body and face.
  • Bruising, itching, sweating, increased sensitivity to the sun, or hair loss.
Urinary:
  • Blood in urine or kidney problems.
Other:
  • Thirst, fever, feeling tired or generally unwell.
  • Sore mouth or mouth ulcers.
  • Muscle pain or weakness.
  • Fertility issues in women.
  • Systemic lupus erythematosus (SLE) symptoms, including fever, rash, kidney problems, and joint pain.
Reporting of side effects: If you experience any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. Reporting side effects helps provide more information on the safety of this medicine.

Do any medicines interact with Naproxen?

Especially:
  • Other painkillers like aspirin, ibuprofen, diclofenac, and paracetamol
  • Diuretics (water tablets for high blood pressure), such as furosemide
  • Medications for high blood pressure
  • Digoxin for heart conditions
  • Lithium or SSRIs (Selective Serotonin Reuptake Inhibitors) like fluoxetine or paroxetine, used for depression treatment
  • Steroid treatments for inflammation, such as prednisolone, hydrocortisone, and dexamethasone
  • Methotrexate for treating rheumatoid arthritis
  • Immunosuppressants like ciclosporin and tacrolimus
  • Antibiotics such as ciprofloxacin and sulphonamides like sulphamethoxazole, used for bacterial infections
  • Mifepristone used in pregnancy terminations (within the last 12 days)
  • Zidovudine for the treatment of AIDS and HIV infections
  • Over-the-counter anti-inflammatory painkillers like ibuprofen
  • Phenytoin for epilepsy treatment
  • Sulphonylureas like gliclazide or glibenclamide for treating diabetes
  • Probenecid for treating gout
  • Anti-platelet agents like aspirin/acetylsalicylic acid, clopidogrel, warfarin, heparin, ticlopidine, and dipyridamole to prevent blood clots
  • Colestyramine for treating high cholesterol levels
  • Antacids
  • Angiotensin-II receptor antagonists, such as candesartan, eprosartan, or losartan

Naproxen FAQs

How should I take Naproxen Tablets with food and drink?

Naproxen Tablets should be taken orally with plenty of water, preferably with food. Try to take them at the same time every day.

Can I take Naproxen Tablets during pregnancy, breastfeeding, or if I'm trying to conceive?

Pregnancy: Do not take Naproxen Tablets if you are in the last three months of pregnancy, as it can harm your baby. If you are pregnant, think you may be pregnant, or are planning to have a baby, consult your doctor or pharmacist before taking this medicine. Breastfeeding: Naproxen passes into breast milk, so you should avoid breastfeeding while taking Naproxen Tablets. Fertility: Naproxen Tablets may make it more difficult to become pregnant. Inform your doctor if you are planning to conceive or if you are experiencing difficulties becoming pregnant.

Can I drive or operate machinery while taking Naproxen Tablets?

Naproxen Tablets may cause side effects such as dizziness, drowsiness, vertigo, difficulty sleeping, depression, tiredness, and visual disturbances. If you experience any of these effects, do not drive or operate machinery.

Can I drink alcohol while taking Naproxen?

No, you should not consume alcohol while taking Naproxen. Alcohol can damage the lining of your stomach and may lead to gastritis, which has very uncomfortable symptoms. Other potential effects of combining alcohol with Naproxen include:
  • Holes in the stomach or intestine
  • Digestive issues or heartburn
  • Bloody vomit or vomit that looks like coffee grounds
  • Blood in stools, or black or tar-like stools

How does Naproxen affect circulation?

Naproxen may slightly increase the risk of heart attack or stroke, particularly with long-term use or if you have existing heart disease. Do not use Naproxen before or after any type of heart surgery.

How does Naproxen affect the stomach?

  • A: Long-term use of Naproxen can cause internal bleeding in the stomach or intestines, which can be fatal if untreated. Watch for symptoms like stomach pain, indigestion, or passing blood or black, tarry stools. If you experience any of these symptoms, seek medical attention immediately.

What should I do before taking Naproxen?

Before taking Naproxen, thoroughly read the Patient Information Leaflet included in the product packaging.

How does Naproxen compare to ibuprofen and diclofenac?

Naproxen vs. Ibuprofen: Naproxen is a stronger anti-inflammatory than ibuprofen and is used for moderate pain and inflammation or when ibuprofen has been ineffective. For a detailed comparison, refer to our Naproxen vs Ibuprofen guide. Naproxen vs. Diclofenac: Naproxen provides a similar level of pain relief and anti-inflammatory activity as diclofenac. Naproxen has largely replaced diclofenac in the UK due to concerns about diclofenac's adverse effects on the heart and gastrointestinal system.

Download patient leaflet

https://www.medicines.org.uk/emc/files/pil.14307.pdf

Checked By
Dr Sarah Thornton
MbChB, Coaching Academy diploma with distinction

Medical coaching


Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Independent prescriber, Superintendent pharmacist.


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