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Triple Combination Erectile Dysfunction Soluble Oral Patch Medium Strength
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APC Labs’s Sildenafil 20mg/Tadalafil 15mg/L-Arginine 2.5mg transmucosal film is a specially compounded medication for erectile dysfunction. This innovative wafer-thin film delivers active ingredients rapidly and efficiently by bypassing the stomach and liver, ensuring more of the drug enters the bloodstream. Combining Sildenafil and Tadalafil provides a fast onset, longer-lasting, and more potent effect, while L-Arginine enhances blood flow for improved results. This advanced delivery system maximizes effectiveness, offering quicker relief and better therapeutic outcomes.
Sildenafil 20mg, Tadalafil 15mg, L-Arginine 2.5mg Transmucosal Buccal Film
APC Labs’s Sildenafil 20mg/Tadalafil 15mg/L-Arginine 2.5mg transmucosal film is a specially compounded medication in a wafer-thin film designed to deliver the active ingredients faster and more efficiently. The transmucosal film is an ingenious drug delivery technology that incorporates both mucoadhesive and rapid dissolve elements, allowing the drugs to enter the bloodstream faster without passing through the stomach and the liver. This means that less of the drug is degraded by the acidic environment of the stomach and by the first-pass effects of the liver, so more enters the circulation to exert its beneficial actions.
The combination of sildenafil and tadalafil allows a rapid onset with a longer duration of action. The addition of L-arginine potentiates the effects. Since arginine is poorly absorbed orally and subject to first-pass metabolism, unlike other formulations, which include an oral form of arginine, with the transmucosal buccal film, the arginine is delivered straight into the bloodstream without being degraded.
The Sildenafil 20mg/Tadalafil 15mg/L-Arginine 2.5mg transmucosal film has been compounded to treat erectile dysfunction.
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Quantity
1 x 4 films, 2 x 4 films, 3 x 4 films, 4 x 4 films
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What is the Triple Combination Erectile Dysfunction Soluble Oral Patch Medium Strength?
APC Labs’s Sildenafil 20mg/Tadalafil 15mg/L-Arginine 2.5mg transmucosal film is a specially compounded medication designed for rapid and efficient delivery of active ingredients used to treat erectile dysfunction. This wafer-thin film utilizes an advanced drug delivery technology that combines mucoadhesive and rapid dissolve properties, allowing the active compounds to enter the bloodstream quickly without passing through the stomach and liver. This bypassing of the digestive system ensures that less of the drug is degraded by stomach acid and liver enzymes, resulting in a higher amount entering the circulation to exert its beneficial effects. The combination of Sildenafil and Tadalafil offers a fast onset and longer-lasting, more potent effect, providing enhanced support for erectile function. Additionally, L-Arginine helps improve blood flow, further contributing to the effectiveness of the treatment. This innovative approach maximizes the medication’s effectiveness, providing faster relief and improved therapeutic outcomes for patients.
What are the active ingredients in the Triple Combination Erectile Dysfunction Soluble Oral Patch Medium Strength?
The active ingredients contained in the buccal film are Sildenafil 20mg, Tadalafil 15mg and L-Arginine 2.5mg.
What is the Triple Combination Erectile Dysfunction Soluble Oral Patch Medium Strength?
APC Labs's Sildenafil 20mg/Tadalafil 15mg/L-Arginine 2.5mg transmucosal film is designed specifically for the treatment of erectile dysfunction. This innovative medication is ideal for those who do not achieve satisfactory results with traditional licensed products. The wafer-thin film utilizes advanced drug delivery technology to bypass the stomach and liver, allowing more of the active ingredients to enter the bloodstream quickly and effectively. Combining Sildenafil and Tadalafil provides a fast onset, longer-lasting, and more potent effect, while L-Arginine enhances blood flow for improved results. This unique formulation ensures a higher concentration of the medication, offering faster relief and better
How does the Triple Combination Erectile Dysfunction Soluble Oral Patch Medium Strength work?
Sildenafil 20mg /Tadalafil 15mg/L-Arginine 2.5mg transmucosal buccal film is a compounded solution to treat erectile dysfunction (ED). This unique formulation combines two potent phosphodiesterase type 5 (PDE5) inhibitors, Tadalafil and Sildenafil, along with L-Arginine, a precursor of nitric oxide (NO), into a single, easy-to-use transmucosal film.
The film is a small, square-shaped wafer designed to adhere to the buccal mucosa and rapidly dissolve to deliver its contents directly to the bloodstream. This administration method allows the medication to be absorbed through the oral mucosa into the circulation without passing through the stomach, small intestine and liver. Sildenafil and Tadalafil work by blocking the actions of the enzyme phosphodiesterase on nitric oxide, the potent vasodilator, while L-Arginine is the precursor to nitric oxide. All three ingredients work synergistically together to produce a rapid erection, which can be achieved over a longer duration of action. This is due to the different half-life of the two phosphodiesterase inhibitors, with sildenafil having a half-life of four hours while tadalafil has a half-life of 17.5 hours. The overall effect is to enhance blood flow to the penis to facilitate an erection.
When using this medication, it is crucial to adhere to the instructions provided by your healthcare provider. The transmucosal film should be placed inside the cheek or under the tongue and left to dissolve entirely. It should not be chewed, swallowed, or broken. For optimal results, the medication should be taken at least 30 minutes before sexual activity. The effects of the drug can last up to 36 hours, providing flexibility and spontaneity.
Like any medication, Sildenafil 20mg/Tadalafil 15mg/Arginine 2.5mg transmucosal film may cause side effects such as headache, nasal congestion, heartburn, flushing, dizziness, and nausea. If you experience any of these or other side effects, it is essential to contact your healthcare provider immediately. Furthermore, this medication may interact with other medicines you are currently taking, so you must inform your doctor about all other medications.
If you have any questions or concerns about Sildenafil 20mg/Tadalafil 15mg/Arginine 2.5mg transmucosal film, please do not hesitate to contact us at APC Labs. We are committed to providing you with the most effective and appropriate treatment for your condition.
How do you use the Triple Combination Erectile Dysfunction Soluble Oral Patch Medium Strength?
The APC Labs team of compounding pharmacists is pleased to present the latest drug delivery technology for treating erectile dysfunction, the Sildenafil 20mg/Tadalafil 15mg/L-Arginine 2.5mg transmucosal buccal film. The formulation is a unique blend of sildenafil, tadalafil, and L-arginine that provides rapid onset with a longer duration of action. The addition of arginine potentiates the overall vasodilatory effect, enhancing the erection. The transmucosal buccal film facilitates rapid delivery of the phosphodiesterase inhibitors into the bloodstream without passing through the stomach and liver. This means not only that an erection occurs within half an hour, but subsequent erections will be able to be achieved due to the longer half-life of tadalafil. The delivery of arginine to potentiate the erection via the buccal route ensures that the hepatic first-pass metabolism does not degrade it. Although many oral preparations contain L-arginine, the claims that it aids erections are placebo at best since it gets blocked from being absorbed by normal bacteria in the intestine in addition to being broken down by the liver. Since L-arginine is the molecule that gets converted to nitric oxide (NO), if it cannot reach the circulation, it cannot exert these effects. However, by compounding the l-arginine alongside sildenafil and tadalafil in a transmucosal film, it can get into the bloodstream without encountering the bacterial gut flora or the liver.
Tadalafil and Sildenafil are both phosphodiesterase type 5 (PDE5) inhibitors which prevent the breakdown of nitric oxide, potentiating its effect on the smooth muscles in the arteries of the penis. While sildenafil and tadalafil prevent the breakdown of nitric oxide, the L-arginine helps form it, being the key molecule that gets converted to nitric oxide.
The Sildenafil 20mg/Tadalafil 15mg/L-Arginine 2.5mg transmucosal buccal film is wafer thin and is applied to the inner cheek or under the tongue. Its unique mucoadhesive properties keep it firmly in place, while its rapid dissolving ability means that within two minutes, the film has delivered its payload. This delivery method facilitates the transfer of the active ingredients within the film to the bloodstream, providing a superior treatment for erectile dysfunction.
It is crucial to note that this Sildenafil 20mg /Tadalafil 15mg/L-Arginine 2.5mg transmucosal film formulation should only be used under the guidance of a healthcare professional. If you have any queries about this formulation or its application, please do not hesitate to contact us at APC Labs. We are committed to providing comprehensive information and support to ensure our compounded medications' safe and effective use.
Always take as directed by your healthcare provider. Check with your healthcare provider if you are not sure.
The sildenafil 20mg, tadalafil 15mg, L-arginine 2.mg transmucosal film should be taken half an hour before sexual intercourse. The effects should start from half an hour and last up to 36 hours. The transmucosal buccal film delivers the drug through the buccal mucosa and straight into the bloodstream.
When we talk about buccal mucosa we are referring to the inside of the mouth. But unlike regular tablets and capsules, which you swallow, you attach the film to the inside of the mouth. As soon as it makes contact with the inside of the cheek, it sticks to it immediately and begins to dissolve. The following list of the steps involved in applying a film:
1. Before removing the film, wash your hands thoroughly and dry them to ensure that the film doesn’t stick to your fingers.
2. Then carefully peel off the film and, with your fingertip, position it on the inside of the cheek.
3. You will feel that the film immediately sticks to the side of the mouth and starts to dissolve.
4. Try not to swallow any saliva while the film is dissolving. The whole purpose of buccal administration is to allow it to dissolve across the inner lining of the mouth into the bloodstream.
5. Only eat or drink something for up to an hour before and after applying the film.
6. The film should dissolve in less than two minutes and may leave a slight aftertaste, depending on your prescribed transmucosal film.
7. Remember to seal the plastic blister tray to prevent the film from being exposed to air, and
either return it to the silver foil envelope or store it in a dark cupboard at room temperature.
To watch a video of how to apply the transmucosal buccal film, please click the following link
https://www.youtube.com/watch?v=ySIOCEqzgvw
Who should not take the Triple Combination Erectile Dysfunction Soluble Oral Patch Medium Strength?
Do not take the Sildenafil 20mg/Tadalafil 15mg/Arginine 2.5mg transmucosal buccal film Transmucosal Film tablets.
• If you are allergic to sildenafil, tadalafil or any of the other ingredients of this medicine. Signs of an allergic reaction include a rash, itching, swollen face or lips and shortness of breath.
• If you take any form of organic nitrate or nitric oxide donors such as amyl nitrite. This is a group of medicines (“nitrates”) used in the treatment of angina pectoris (“chest pain”). Sildenafil and Tadalafil have been shown to increase the effects of
these medicines. If you are taking nitrates or are unsure, please speak to your GP or pharmacist.
• If you have severe heart disease or recently had a heart attack within the last 90 days.
• If you have recently had a stroke within the last six months.
• If you have low blood pressure or uncontrolled high blood pressure.
• If you have ever had a condition involving loss of vision due to damage to the optic nerve from insufficient blood supply, known as non-arteritic ischemic optic neuropathy (NAION)
• If you are taking riociguat. This drug treats pulmonary arterial hypertension (i.e. high blood pressure in the lungs) and chronic thromboembolic pulmonary hypertension (i.e. high blood pressure in the lungs secondary to blood clots). PDE5 inhibitors, such as Sildenafil and Tadalafil, have been shown to increase the hypotensive effects of this medicine. If you are taking riociguat or are unsure, ask your doctor or pharmacist.
Warnings and precautions
Talk to your pharmacist or medical provider before taking Sildenafil 20mg/Tadalafil 15mg/Arginine 2.5mg transmucosal buccal film Transmucosal Film tablets.
Take special care with Sildenafil 20mg/Tadalafil 15mg/Arginine 2.5mg transmucosal buccal film Transmucosal Film tablets.
• If you have heart trouble. It may be risky for you to have sex.
• If you suffer from an irregular heartbeat (cardiac arrhythmia) or inherited heart disease affecting your electrocardiogram.
• If you have a physical condition affecting the shape of your penis. This includes conditions called angulation, Peyronie’s disease and cavernosal fibrosis.
• If you have an illness that can cause erections which won’t go away (priapism). These includesickle cell disease, multiple myeloma and leukaemia.
• If you have stomach ulcers (also called gastric or peptic ulcers).
• If you have a bleeding disorder ( such as haemophilia)
• If you have serious liver or kidney problems.
• If you are using any other treatments for erection difficulties (see section Other medicines and sildenafil and tadalafil transmucosal film).
• If you experience a sudden decrease or loss of vision or loss of hearing, stop taking Sildenafil 20mg/Tadalafil 15mg/Arginine 2.5mg transmucosal buccal film Transmucosal Film tablets and contact your doctor immediately.
• It is not known if tadalafil is effective in patients who have had pelvic surgery or removal of all or part of the prostate gland in which nerves of the prostate are cut.
Children and adolescents
Sildenafil 20mg/Tadalafil 15mg/Arginine 2.5mg transmucosal buccal film Transmucosal Film tablets are not intended for use by children or adolescents under 18.
What are the side effects with the Triple Combination Erectile Dysfunction Soluble Oral Patch Medium Strength?
This medicine can cause side effects like all medicines, although not everybody gets them. These effects are generally mild to moderate in nature.
If you experience any of the following side effects, stop using the medicine and seek medical help immediately:
Allergic reactions including rashes (frequency uncommon); chest pain (frequency uncommon);priapism, a prolonged and possibly painful erection which lasts continuously for more than 4 hours after taking Sildenafil or Tadalafil (frequency rare); sudden loss of vision (frequency rare).
The following categories describe the chance of having a side effect:
Common symptoms (which may affect up to 1 in 10 people) include headache, back pain, muscle aches, pain in arms and legs, facial flushing, nasal congestion, nausea, indigestion, and visual disturbances.
Uncommon (may affect up to 1 in 100 people) symptoms include dizziness, stomach ache, feeling sick, being sick (vomiting), reflux, blurred vision, eye pain, difficulty breathing, prescence of blood in urine, prolonged erection, pounding heartbeat sensation, fast heart rate, high blood pressure, low blood pressure, nose bleeds, ringing in the ears, swelling of the hands, feet or ankles, and feeling tired.
Rare ( may affect up to 1 in 1,000 people): fainting, seizures, passing memory loss, swelling of the eyelids, red eyes, sudden decrease or loss of hearing, hives (itchy red welts on the surface of the skin), penile bleeding, presence of blood in semen, and increased sweating.
Heart attack and stroke have also been reported rarely in men taking Sildenafil and Tadalafil. Most of these men had known heart problems before taking this medicine. Partial, temporary, or permanent decrease or loss of vision in one or both eyes has been rarely reported. Some additional rare side effects in men taking Sildenafil and Tadalafil were not seen in clinical trials. These include migraine, swelling of the face, a serious allergic reaction which causes swelling of the face or throat, serious
skin rashes, some disorders affecting blood flow to the eyes, irregular heartbeats, angina and sudden cardiac death. The side effect of dizziness has been reported more frequently in men over 75 years of age taking Sildenafil and Tadalafil. Diarrhoea has been reported more frequently in men over 65 years of age taking Sildenafil and Tadalafil.
Reporting of side effects
Talk to your pharmacist or medical provider if you get any side effects. This includes any possible side effects not listed in this leaflet. You may also report side effects directly via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard.
Does the Triple Combination Erectile Dysfunction Soluble Oral Patch Medium Strength interact with other medicines?
Do not use Sildenafil 20mg/Tadalafil 15mg/Arginine 2.5mg transmucosal buccal film Transmucosal Film tablets combined with any other treatment for erectile dysfunction.
Please tell your doctor or pharmacist if you have recently used or might use any other medicines, including those obtained without a prescription.
Some medicines may cause problems, especially these:
• Nitrates, medicines for angina, or nitric oxide donors, such as amyl nitrite. Taking these medicines with Sildenafil 20mg/Tadalafil 15mg/Arginine 2.5mg transmucosal buccal film Transmucosal Film tablets could seriously affect your blood pressure.
• Medicine for treating arrhythmias, such as quinidine, procainamide, amiodarone or sotalol.
• Ritonavair or indinavir, medicines for HIV.
• Ketoconazole or itraconazole, antifungal medicines
• Erythromycin or clarithromycin, macrolide antibiotics
• Alpha-blockers, a type of medicine used to treat high blood pressure and enlargement of the prostate ( as benign prostatic hyperplasia).
• Riociguat.
Triple Combination Erectile Dysfunction Soluble Oral Patch Medium Strength FAQs
What is the Sildenafil 20mg/Tadalafil 15mg/Arginine 2.5mg transmucosal film?
APC Labs's Sildenafil 20mg/Tadalafil 15mg/L-Arginine 2.5mg transmucosal film is a specially compounded medication in a wafer-thin film designed to deliver the active ingredients faster and more efficiently. The transmucosal film is an ingenious drug delivery technology that incorporates both mucoadhesive and rapid dissolve elements, allowing the drugs to enter the bloodstream faster without passing through the stomach and the liver. The formulation is a unique blend of sildenafil, tadalafil, and L-arginine that provides rapid onset with a longer duration of action. The addition of arginine potentiates the overall vasodilatory effect, enhancing the erection. The transmucosal buccal film facilitates faster phosphodiesterase delivery into the bloodstream without passing through the stomach and liver. This means not only that an erection occurs within half an hour, but subsequent erections will be able to be achieved within an increased time frame due to the longer half-life of tadalafil.
How should I take this medication?
You should place the transmucosal film against the side of the inner cheek and allow it to dissolve completely. Do not swallow or chew the film, as it is designed to be absorbed through the oral mucosa.
What are the benefits of this compounded formulation?
The combination of Tadalafil, Sildenafil, and L-arginine in a transmucosal film facilitates rapid erections, with the ability for further erections for a greater period of time due to the longer half-life of tadalafil. The L-arginine is not absorbed orally and is subject to first-pass metabolism; hence, the buccal route ensures that the L-arginine reaches the circulation. The three ingredients work synergistically to facilitate an erection. The film is quick and easy to use and works rapidly.
What are the potential side effects of this medication?
As with any medication, side effects can occur. Common side effects may include headache, nasal congestion, flushing, upset stomach, abnormal vision, and muscle pain. Contact your healthcare provider immediately if you experience any severe or persistent side effects.
Can I take this medication with food?
Yes, this medication can be taken with or without food. However, it is recommended that you avoid consuming high-fat meals, as they may delay the medication's absorption.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it is close to your next dose, skip the missed dose and return to your regular dosing schedule. Do not take two doses at the same time.
Can I drink alcohol while taking this medication?
It is generally recommended to avoid alcohol while taking this medication as it may increase the risk of side effects such as dizziness and light-headedness.
How should I store this medication?
This medication should be stored at room temperature in the sealed plastic blister tray away from heat, light, and moisture. It should also be kept out of the reach of children and pets.
What should I do in case of an overdose?
If you suspect an overdose, seek immediate medical attention or contact your Accident and Emergency Department. Symptoms of overdose may include severe dizziness, fainting, or an erection lasting longer than 4 hours.
