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Imigran Nasal Spray 20mg

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Imigran Nasal Spray is a fast-acting treatment for migraines, designed to provide relief from the intense pain and associated symptoms. Each spray contains sumatriptan, a potent triptan medication that helps alleviate migraine attacks by narrowing dilated blood vessels in the brain. Conveniently delivered as a single-use spray, Imigran Nasal Spray offers a practical alternative for those who have difficulty swallowing tablets. Available in 10mg and 20mg doses, it is most effective when used at the onset of a migraine, providing significant relief in approximately 30 minutes. Ideal for individuals seeking prompt and effective migraine relief, this nasal spray is an essential option for managing severe migraine episodes.

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Imigran Nasal Spray 20mg
SKU: IMISPR20 Category: Tags: ,

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1 x 2 sprays, 2 x 2 sprays, 3 x 3 sprays

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Overview

Active ingredients

What is it for?

How does it work?

How do you use it?

Warnings and precautions

Side effects

Drug interactions

FAQs

Download patent leaflet

Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Independent prescriber, Superintendent pharmacist.


Checked By
Dr Sarah Thornton
MbChB, Coaching Academy diploma with distinction

Medical coaching


What is Imigran Nasal Spray 20mg?

Imigran Nasal Spray is a fast-acting medication designed to treat acute migraine attacks. It contains the active ingredient sumatriptan, a triptan that works by targeting serotonin receptors in the brain to alleviate migraine symptoms. The nasal spray formulation allows for rapid absorption through the nasal mucosa, providing quick relief from headache, nausea, and sensitivity to light and sound. Typically administered as one spray into one nostril, it can be used up to twice within a 24-hour period if needed. Imigran Nasal Spray is especially useful for those who prefer a non-oral option or have difficulty taking tablets during a migraine. However, it should be used with caution in individuals with certain health conditions, and consulting a healthcare provider is recommended to ensure its suitability.

What is the active ingredient in Imigran Nasal Spray 20mg?

The active ingredient contained in Imigran Nasal Spray is sumatriptan.

What is Imigran Nasal Spray 20mg used for?

Imigran Nasal Spray 20mg is used for the acute treatment of migraine attacks. It contains sumatriptan, a medication from the triptan class that specifically targets serotonin receptors in the brain. By doing so, it helps alleviate common migraine symptoms such as severe headache, nausea, and sensitivity to light and sound. The nasal spray formulation allows for rapid absorption through the nasal passages, providing quick relief. It is typically used when a migraine attack starts and can be administered up to twice in a 24-hour period if needed.

How does Imigran Nasal Spray 20mg work?

Imigran Nasal Spray 20mg works by delivering sumatriptan, a selective serotonin receptor agonist, directly to the nasal mucosa. While the exact cause of migraines is not fully understood, they are believed to be triggered by the dilation of blood vessels in the brain, leading to throbbing pain. Sumatriptan, as a serotonin agonist, mimics the effects of serotonin—a neurotransmitter that can narrow these dilated blood vessels and reduce the associated pain. By stimulating specific serotonin receptors in the brain, sumatriptan alleviates the throbbing pain of a migraine. The nasal spray is most effective when used at the onset of a migraine attack, although it can still provide relief if used later in the episode. After application to one nostril, it generally takes about 30 minutes to start working. Imigran Nasal Spray does not prevent migraines but can be safely used in conjunction with preventive treatments, such as propranolol.  

How do you use Imigran Nasal Spray 20mg?

When should you use Imigran Nasal Spray? Use Imigran Nasal Spray only after your migraine headache begins. It is not intended for preventing a migraine. For best results, use the spray as soon as you feel a migraine coming on, although it can still be effective if used later during the attack. How much Imigran Nasal Spray should you use?
  • Adults (18 to 65 years): The typical dose is one 20 mg spray into one nostril. In some cases, one 10 mg spray into one nostril may be sufficient. Do not use more than two sprays within a 24-hour period.
  • Adolescents (12 to 17 years): The usual dose is one 10 mg spray into one nostril.
  • Children under 12 years: Imigran Nasal Spray is not recommended for children under 12.
  • Older Adults (over 65 years): Imigran Nasal Spray is not recommended for those over 65.
What should you do if symptoms start to return? If your symptoms return after using Imigran Nasal Spray, you may use a second spray after 2 hours. Do not exceed two sprays within a 24-hour period. What if the first spray doesn’t work? If the first dose does not relieve your migraine, do not use a second spray or any other Imigran product for the same attack. Consult your doctor or pharmacist for further advice. What if you use too much Imigran Nasal Spray? Do not use more than two sprays within a 24-hour period. Overuse may lead to adverse effects. If you have used more than the recommended dose, contact your doctor for guidance. How to use Imigran Nasal Spray:
  1. Remove the spray from the blister packaging just before use. Ensure the spray is intact and sealed.
  2. Find a comfortable position; sitting may be preferable.
  3. Blow your nose if it feels blocked or if you have a cold.
  4. Hold the spray with your fingers and thumb, as shown in the guide, without pressing the blue plunger.
  5. Block one nostril by pressing a finger on the side of your nose. The choice of nostril is up to you.
  6. Insert the nozzle into the other nostril as far as comfortable, about 1 cm or ½ inch. Breathe out gently through your mouth.
  7. Keep your head upright and close your mouth. As you begin to breathe in gently through your nose, press the blue plunger firmly with your thumb. The plunger may be stiff and you might hear a click.
  8. After spraying, remove the nozzle and your finger from your nose. Keep your head upright and breathe gently in through your nose and out through your mouth for 10-20 seconds. This helps the medicine stay in your nose.
  9. Dispose of the used spray safely and hygienically.
If you have any questions or need further assistance with using Imigran Nasal Spray, consult your doctor or pharmacist.

Who should not use Imigran Nasal Spray 20mg?

Do not use Imigran if:
  • You are allergic to sumatriptan or any other ingredients in this medicine, please refer to patient information leaflet.
  • You have a heart condition, such as ischemic heart disease (narrowing of the arteries), angina (chest pain), or a history of heart attack.
  • You suffer from peripheral vascular disease (circulation problems in the legs causing cramp-like pain when walking).
  • You have experienced a stroke or a transient ischemic attack (TIA, also known as a mini-stroke).
  • You have high blood pressure. Imigran may be used if your high blood pressure is mild and well-controlled.
  • You have severe liver disease.
  • You are using other migraine treatments that include ergotamine, methysergide, or any other triptans/5-HT1 receptor agonists.
  • You are taking monoamine oxidase inhibitors (MAOIs) or have taken them in the past two weeks.
If any of these conditions apply to you:
  • Inform your doctor and do not use Imigran Nasal Spray.
Take special care with Imigran if:
  • You are a heavy smoker or using nicotine replacement therapy, especially if you are over 40 years old or a postmenopausal woman. There have been rare cases of serious heart conditions developing after using Imigran, even in those with no prior heart disease. Let your doctor know so your heart function can be monitored before Imigran is prescribed.
  • You have a history of seizures or other conditions that may increase the risk of seizures, such as head injury or alcoholism. Inform your doctor to ensure closer supervision.
  • You have liver or kidney disease. Notify your doctor for closer monitoring.
  • You are allergic to sulphonamide antibiotics. If unsure whether you are allergic to sulphonamides, inform your doctor or pharmacist before using Imigran.
  • You are taking selective serotonin reuptake inhibitors (SSRIs) or serotonin-noradrenaline reuptake inhibitors (SNRIs). Let your doctor or pharmacist know before using Imigran, and review interactions with other medicines.
  • You use Imigran frequently. Overuse may worsen your headaches. Inform your doctor if this is the case, as they may suggest stopping Imigran.
If you experience chest pain or tightness after using Imigran:
  • These symptoms may be intense but usually resolve quickly. If they persist or become severe, seek medical help immediately.
Pregnancy and Breast-Feeding
  • If you are pregnant, suspect you might be pregnant, or are planning to become pregnant, consult your doctor before using this medication. There is limited information on the safety of Imigran during pregnancy, but there is currently no evidence suggesting an increased risk of birth defects. Your doctor will help determine if Imigran is suitable for you during pregnancy.
  • Avoid breastfeeding for 12 hours after using Imigran. If you pump breast milk during this period, discard it and do not feed it to your baby.
Driving and Using Machinery
  • Migraine symptoms or the effects of the medication may cause drowsiness. If you experience any drowsiness, avoid driving or operating machinery.

What are the side effects with Imigran Nasal Spray 20mg?

Like all medications, Imigran can cause side effects, although not everyone experiences them. Some symptoms may be related to the migraine itself. Allergic Reactions: If you experience signs of an allergic reaction, such as rash, hives (itchy rash), wheezing, swelling of the eyelids, face, or lips, or sudden collapse, seek medical help immediately. If you notice any of these symptoms shortly after using Imigran, stop using the medicine and contact your doctor right away. Very Common Side Effects (affect more than 1 in 10 people):
  • Unpleasant taste.
Common Side Effects (affect up to 1 in 10 people):
  • Chest, throat, or body pressure, tightness, or pain, as well as unusual sensations like numbness, tingling, or warmth/cold. These effects are generally intense but usually resolve quickly. Seek urgent medical help if these symptoms persist or become severe, as they can sometimes indicate a heart attack.
  • Nasal or throat irritation or burning sensation; nosebleeds.
  • Nausea or vomiting, which may be due to the migraine.
  • Tiredness or drowsiness.
  • Dizziness, weakness, or hot flushes.
  • Temporary increase in blood pressure.
  • Shortness of breath.
  • Muscle aches.
Very Rare Side Effects (affect up to 1 in 10,000 people):
  • Changes in liver function. If you have a liver function test, inform your healthcare provider that you are using Imigran.
Rarely Reported Side Effects (frequency unknown):
  • Seizures, tremors, temporary muscle spasms affecting the jaw, and neck stiffness.
  • Visual disturbances such as flickering, reduced vision, double vision, loss of vision, or permanent defects (these may also be related to the migraine).
  • Heart issues, including changes in heart rate or rhythm, chest pain, or heart attack.
  • Raynaud’s phenomenon, which causes pale or blue-tinged skin and pain in extremities in response to cold or stress.
  • Feeling faint due to lowered blood pressure.
  • Abdominal pain on the lower left side and bloody diarrhea (ischemic colitis).
  • Diarrhea.
  • Increased pain at sites of recent injury or inflammation, or joint pain.
  • Anxiety, difficulty swallowing, excessive sweating.
Reporting Side Effects If you experience any side effects, including those not listed here, consult your doctor, pharmacist, or nurse. You can also report side effects directly through the Yellow Card Scheme at www.mhra.gov.uk/yellowcard or by searching for MHRA Yellow Card in the Google Play or Apple App Store. Reporting side effects helps provide more information on the safety of this medicine.

Does Imigran Nasal Spray 20mg interact with other medicines?

Inform Your Doctor or Pharmacist
  • Let your doctor or pharmacist know if you are currently taking, have recently taken, or plan to take any other medicines, including herbal products or over-the-counter medications.
  • Certain medications should not be used with Imigran, while others may cause adverse effects when combined with it. Specifically, inform your doctor if you are taking:
    • Ergotamine or similar medications (e.g., methysergide) used for migraine treatment. Do not use Imigran concurrently with these medicines. Cease using these medications at least 24 hours before using Imigran. Avoid taking any ergotamine-containing medicines again for at least 6 hours after using Imigran.
    • Other triptans/5-HT1 receptor agonists (e.g., naratriptan, rizatriptan, zolmitriptan) used for migraine relief. Do not use Imigran with these medications. Stop using them at least 24 hours before using Imigran, and wait at least 24 hours before taking another triptan/5-HT1 receptor agonist after using Imigran.
    • SSRIs (Selective Serotonin Reuptake Inhibitors) or SNRIs (Serotonin Noradrenaline Reuptake Inhibitors), which are used to treat depression. Combining Imigran with these medications can lead to serotonin syndrome, which may cause symptoms such as restlessness, confusion, sweating, hallucinations, increased reflexes, muscle spasms, shivering, increased heartbeat, and shaking. Contact your doctor immediately if you experience any of these symptoms.
    • MAOIs (Monoamine Oxidase Inhibitors) used for depression. Do not use Imigran if you have taken these within the last 2 weeks.
    • St John’s Wort (Hypericum perforatum). Herbal remedies containing St John’s Wort may increase the likelihood of side effects when used with Imigran.

Imigran Nasal Spray 20mg FAQs

What is Imigran and what is it used for?

Imigran Nasal Spray is a medication designed to provide relief from migraine symptoms. It contains sumatriptan, a type of 'triptan' medicine widely used to treat migraines. Ideal for those who cannot swallow tablets, it is available in single-use sprays of 10mg or 20mg.

How does Imigran work?

The exact cause of migraines isn't fully understood, but they are believed to be linked to the dilation of blood vessels in the brain, leading to throbbing pain. Sumatriptan, the active ingredient in Imigran, is a serotonin agonist. It works by stimulating serotonin receptors in the brain, causing the blood vessels to constrict and thus relieving the migraine pain. For best results, use Imigran Nasal Spray at the onset of a migraine, though it can still be effective if used later in the attack.

What is a migraine?

Migraines are severe headaches that affect about 25% of women and 8% of men in the UK. They can be triggered by various factors, including genetics, alcohol, poor diet, caffeine, stress, lack of sleep, and in some cases, hormonal changes in women. Symptoms often include intense throbbing pain, nausea, and heightened sensitivity to light, noise, and smells. Migraines may last a few hours to three days, with lingering fatigue afterward.

What are the alternatives to Imigran?

Aside from Imigran, there are several alternatives for treating and preventing migraines. For initial relief, you might consider over-the-counter options such as paracetamol, ibuprofen, aspirin, or Migraleve. For more advanced treatments, Vydura is a newly developed option available through The Independent Pharmacy.

What are the warnings for Imigran?

Imigran Nasal Spray is not suitable if you have had a heart attack or stroke, have pre-existing circulation issues, high blood pressure, liver disease, or are taking MAOIs or other triptans. Consult your doctor if you have a high risk of heart disease, a history of epilepsy, or experience chest tightness after using Imigran.

How should Imigran be used?

For best results, use Imigran Nasal Spray at the start of a migraine attack. Administer 10-20mg into one nostril. If needed, a second dose can be taken after at least two hours. Follow these steps: blow your nose if needed, hold the spray, insert the nozzle into one nostril, block the other nostril with a finger, and press the blue plunger while inhaling gently. After use, breathe in gently through your nose for 10 seconds and then discard the used spray.

What are the ingredients in Imigran?

Imigran Nasal Spray contains the active ingredient sumatriptan. Inactive ingredients include potassium dihydrogen phosphate, dibasic sodium phosphate anhydrous, sulfuric acid, sodium hydroxide, and purified water.

What are the side effects of Imigran?

Possible side effects include chest or throat tightness, tingling sensations, nasal or throat irritation, nosebleeds, nausea, fatigue, dizziness, hot flushes, aches, and shortness of breath. If you experience any concerning effects, stop using the spray and consult your doctor or pharmacist.

Download patient leaflet

https://www.medicines.org.uk/emc/files/pil.2214.pdf

Checked By
Dr Sarah Thornton
MbChB, Coaching Academy diploma with distinction

Medical coaching


Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Independent prescriber, Superintendent pharmacist.


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