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Vydura 75mg Tablets for Prevention

from£320.00

Vydura is a medication used to both treat and prevent migraines in adults. It contains the active ingredient rimegepant, which belongs to a class of drugs known as Gepants. Vydura works by blocking the action of calcitonin gene-related peptide (CGRP), a substance involved in migraine pain. This medication is available in the form of an oral lyophilisate, a wafer that dissolves on or under the tongue, offering rapid relief without the need for water. For migraine treatment, it is used as needed, while for prevention, it is taken every other day. Vydura is well-tolerated, with common side effects including nausea. It is essential to follow dosing guidelines and consult a healthcare provider for personalized advice and potential interactions with other medications.

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Vydura 75mg Tablets for Prevention
SKU: VYDPRE75 Category: Tags: ,

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16 wafers, 32 wafers

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Overview

Active ingredients

What is it for?

How does it work?

How do you use it?

Warnings and precautions

Side effects

Drug interactions

FAQs

Download patent leaflet

Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Independent prescriber, Superintendent pharmacist.


Checked By
Dr Sarah Thornton
MbChB, Coaching Academy diploma with distinction

Medical coaching


What is Vydura 75mg?

VYDURA contains the active ingredient rimegepant, which works by inhibiting the action of a substance in the body called calcitonin gene-related peptide (CGRP). Elevated levels of CGRP are often found in people with migraines. Rimegepant binds to the CGRP receptor, blocking CGRP from attaching to it. This action reduces CGRP activity, which can:

  1. Stop an ongoing migraine attack.
  2. Decrease the frequency of migraine attacks when used as a preventive measure.

VYDURA is prescribed to both treat and prevent migraine attacks in adults.

What is the active ingredient in Vydura 75mg?

Each Vydura tablet contains rimegepant sulfate, equivalent to 75 mg rimegepant.

What is Vydura 75mg used for?

VYDURA 75mg is used for the treatment and prevention of migraine attacks in adults. The active ingredient, rimegepant, works by inhibiting the action of calcitonin gene-related peptide (CGRP), a substance that plays a role in migraine attacks. By blocking the CGRP receptor, VYDURA can:
  1. Stop an Active Migraine Attack: It helps to alleviate symptoms during an ongoing migraine.
  2. Prevent Future Migraine Attacks: When taken regularly, it can reduce the frequency of migraine episodes.
This dual action makes VYDURA a versatile option for managing migraines.  

How does Vydura 75mg work?

VYDURA 75mg contains rimegepant, which targets and blocks the action of a substance called calcitonin gene-related peptide (CGRP). Elevated levels of CGRP are associated with migraine attacks. Here’s how it works:
  1. Inhibition of CGRP Activity: Rimegepant binds to CGRP receptors, preventing CGRP from attaching to them. This reduces the activity of CGRP in the brain.
  2. Effects on Migraine:
    • During an Attack: By blocking CGRP, VYDURA helps to relieve symptoms and can stop an active migraine attack.
    • Preventively: Regular use can decrease the frequency of migraine attacks by reducing CGRP’s role in triggering them.
Overall, VYDURA helps to manage migraines by addressing a key biochemical factor involved in the migraine process.  

How do you use Vydura 75mg?

Always follow your doctor’s or pharmacist’s instructions when taking this medicine. If you have any doubts, consult them for clarification. Dosage Instructions:
  • For Migraine Prevention: Take one oral lyophilisate (75 mg rimegepant) every other day.
  • For Acute Migraine Treatment: Take one oral lyophilisate (75 mg rimegepant) as needed, but not more than once per day. The maximum daily dose is one oral lyophilisate.
How to Take VYDURA:
  • Administration: VYDURA is for oral use.
  • With or Without Food: You can take the oral lyophilisate with or without food and water.
Instructions for Use:
  1. Use dry hands to open the blister pack. Peel back the foil of one blister and gently remove the oral lyophilisate. Avoid pushing the lyophilisate through the foil.
  2. Place the oral lyophilisate on or under your tongue as soon as the blister is opened. It will dissolve on its own, and no water is needed.
  3. Do not store the oral lyophilisate outside the blister for future use.
If You Take Too Much VYDURA: Seek immediate advice from your doctor or pharmacist or go to the nearest hospital. Bring the medicine pack and this leaflet with you. If You Miss a Dose:
  • For Prevention: If you miss a dose, take your next dose at the regular time. Do not double up on doses to make up for a missed one.
If you have any additional questions about using this medicine, please consult your doctor or pharmacist.

Who should not take Vydura 75mg?

Do not take VYDURA:
  • If you are allergic to rimegepant or any other ingredients in this medicine, please refer to patient information leaflet.
Warnings and Precautions: Consult your doctor or pharmacist before using VYDURA if you have:
  • Severe liver issues
  • Reduced kidney function or are undergoing kidney dialysis
During treatment with VYDURA, discontinue use and inform your doctor immediately if you experience:
  • Symptoms of an allergic reaction, such as difficulty breathing or a severe rash, which can appear several days after taking the medicine.
Children and Adolescents: VYDURA is not recommended for individuals under 18 years of age, as it has not been studied in this age group. Interactions with Other Medicines: Inform your doctor or pharmacist if you are taking, have recently taken, or plan to take any other medicines. Some medications may affect how VYDURA works, or VYDURA may influence the effectiveness of other medicines. Pregnancy and Breast-Feeding:
  • Pregnancy: If you are pregnant, think you may be pregnant, or plan to become pregnant, seek advice from your doctor or pharmacist before using VYDURA. It is advisable to avoid using VYDURA during pregnancy due to unknown effects on pregnant women.
  • Breast-Feeding: If you are breast-feeding or planning to breast-feed, consult your doctor or pharmacist before using this medicine. You and your doctor should decide whether to use VYDURA while breast-feeding.
Driving and Using Machines: VYDURA is not expected to impair your ability to drive or operate machinery.

What are the side effects with Vydura 75mg?

Like all medications, VYDURA can cause side effects, though not everyone experiences them. If you notice signs of an allergic reaction, such as a severe rash or difficulty breathing, stop using VYDURA and contact your doctor immediately. Allergic reactions are rare, affecting up to 1 in 100 people. A common side effect of VYDURA is nausea, which may affect up to 1 in 10 people. Reporting Side Effects If you experience any side effects, including those not listed in this leaflet, consult your doctor, pharmacist, or nurse. You can also report side effects directly through the Yellow Card Scheme at www.mhra.gov.uk/yellowcard or by searching for "MHRA Yellow Card" in the Google Play or Apple App Store. Reporting side effects helps provide more information about the safety of this medicine.

Does Vydura 75mg interact with other medicines?

Inform your doctor or pharmacist if you are taking, have recently taken, or plan to take any other medications. This is important because some medicines may affect how VYDURA works, or VYDURA may influence how other medicines work. Here are examples of medicines that should be avoided while taking VYDURA:
  • Itraconazole and clarithromycin: Used for treating fungal and bacterial infections.
  • Ritonavir and efavirenz: Used for treating HIV infections.
  • Bosentan: Used for managing high blood pressure.
  • St. John’s wort: A herbal remedy for depression.
  • Phenobarbital: Used to treat epilepsy.
  • Rifampicin: Used for treating tuberculosis.
  • Modafinil: Used for treating narcolepsy.
Additionally, do not use VYDURA more than once every 48 hours if you are taking:
  • Fluconazole and erythromycin: Used for fungal and bacterial infections.
  • Diltiazem, quinidine, and verapamil: Used for abnormal heart rhythms, chest pain (angina), or high blood pressure.
  • Cyclosporin: Used to prevent organ rejection after transplantation.

Vydura 75mg FAQs

What is Vydura 75mg used for?

Vydura is used to treat and prevent migraines. It contains rimegepant, which helps manage migraine symptoms and reduce the frequency of attacks.

How effective is rimegepant (Vydura)?

Clinical trials have shown that rimegepant is quite effective for migraine relief. It has been found to:
  • Provide pain relief within two hours for 59% of patients
  • Leave 21% of patients pain-free within two hours
  • Alleviate the ‘most bothersome symptom’ for 35% of patients within two hours
  • Offer continued pain relief between two and 48 hours after the first dose for 42% of patients
  • Ensure that 86% of patients did not require additional pain relief in the first 24 hours

How does Vydura work to treat migraines?

Vydura contains rimegepant, which belongs to a new class of migraine medications known as Gepants. It works by blocking CGRP (calcitonin gene-related peptide) receptors in the brain, which helps to reduce the symptoms and pain associated with migraines. It can be used both to treat a migraine once it starts and as a preventive measure to reduce the frequency of migraines.

What other prescription medications are available for migraines?

In addition to Vydura, we offer a variety of migraine relief options, including:
  • Triptans:
    • Almotriptan 12.5mg tablets
    • Migard (frovatriptan) 2.5mg tablets
  • Nasal Sprays:
    • Imigran (sumatriptan) 10mg & 20mg
  • Wafer Melts:
    • Maxalt Melt (rizatriptan) 10mg
    • Rizatriptan 10mg

What over-the-counter medications can be used for migraines?

Some over-the-counter options include:
  • Paracetamol
  • Ibuprofen
  • Aspirin
  • Buccastem M for nausea

How should Vydura be taken?

Place one wafer under your tongue and let it dissolve. You do not need to take it with food or drink. If necessary, you can take another wafer after 24 hours. For prevention, take one wafer every other day. Do not exceed one wafer per 24 hours.

What are the ingredients in Vydura?

Each Vydura wafer contains 75 mg of rimegepant sulfate. It also includes gelatin, mannitol (E421), mint flavor, and sucralose.

What are the potential side effects of Vydura?

Common side effects include nausea. Uncommon but serious allergic reactions, such as rash or shortness of breath, can occur. If you experience these symptoms, seek immediate medical attention.

What are the warnings for taking Vydura?

Do not take Vydura if you are allergic to rimegepant or any other ingredients. It is also unsuitable for individuals with severe liver problems or reduced kidney function. Avoid taking Vydura with certain medications, such as:
  • Itraconazole and clarithromycin (for fungal or bacterial infections)
  • Ritonavir and efavirenz (for HIV infections)
  • Bosentan (for high blood pressure)
  • St. John’s wort (for depression)
  • Phenobarbital (for epilepsy)
  • Rifampicin (for tuberculosis)
  • Modafinil (for narcolepsy)
  • Fluconazole and erythromycin (for fungal or bacterial infections)
  • Diltiazem, quinidine, and verapamil (for heart rhythm issues or high blood pressure)
  • Cyclosporin (for organ transplant prevention)
For assistance with medications, please consult our medical team.

What should I do if I miss a dose of Vydura?

If you miss a dose of Vydura and are taking it for migraine prevention, take the next dose at the usual time. Do not take a double dose to make up for a missed one. For acute treatment, if you miss a dose, wait at least 24 hours before taking another wafer.

Can Vydura be used during pregnancy or while breastfeeding?

It is preferable to avoid using Vydura during pregnancy as its effects on pregnant women are not well established. If you are pregnant, planning to become pregnant, or think you might be pregnant, consult your doctor before using this medicine. If you are breastfeeding or planning to breastfeed, discuss with your doctor or pharmacist whether Vydura is appropriate for you.

Does Vydura affect my ability to drive or use machinery?

Vydura is not expected to affect your ability to drive or operate machinery. However, if you experience any side effects that impair your alertness, avoid driving or using machinery until you are sure you are unaffected.

Can I take Vydura with other medications?

Inform your doctor or pharmacist about all the other medications you are taking, including over-the-counter drugs and supplements. Certain medications may interact with Vydura, affecting how it works or increasing the risk of side effects.

What should I do if I take too much Vydura?

If you take more Vydura than prescribed, contact your doctor or pharmacist immediately or go to the nearest hospital. Bring the medicine pack and leaflet with you for reference.

Are there any specific conditions that might affect my use of Vydura?

Before taking Vydura, inform your doctor if you have severe liver problems, reduced kidney function, or if you are on dialysis. Additionally, let your doctor know if you have a history of allergies or if you are taking other medications that might interact with Vydura.

How should Vydura be stored?

Store Vydura at room temperature, away from moisture and heat. Keep the wafers in their original blister pack until you are ready to use them. Do not store the wafers outside the blister pack for future use.

Can Vydura be used in combination with other migraine treatments?

Do not use Vydura simultaneously with other migraine treatments, especially those containing triptans or ergotamine. Consult your doctor about safe options if you need additional migraine management.

What should I do if I have further questions about Vydura?

For any additional questions or concerns about Vydura, consult your doctor, pharmacist, or healthcare provider. They can provide detailed information and guidance based on your individual health needs.

Download patient leaflet

https://www.medicines.org.uk/emc/files/pil.13928.pdf

Checked By
Dr Sarah Thornton
MbChB, Coaching Academy diploma with distinction

Medical coaching


Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Independent prescriber, Superintendent pharmacist.


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