Rizatriptan 10mg oral dispersible tablets Medicalmojo.co.uk

Rizatriptan 10mg Orodispersible Tablets

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Rizatriptan 10mg Orodispersible Tablets are a medication used to treat migraine headaches. These tablets are designed to dissolve quickly on the tongue, making them ideal for individuals who have difficulty swallowing pills or prefer a more convenient option. Rizatriptan works by stimulating serotonin receptors in the brain, which helps reduce the inflammation and constriction of blood vessels that contribute to migraine pain. It is important to take Rizatriptan as soon as possible after the onset of a migraine and not to use it for preventing migraines. Each box contains orodispersible tablets that provide effective relief from migraine symptoms.

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Rizatriptan 10mg Orodispersible Tablets

SKU: RIZDIS10 Category: Migraine Tags: Orodispersible tablet, W Prescription

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Quantity	1 x 3 tablets, 2 x 6 tablets, 3 x 6 tablets

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How does it work?

How do you use it?

Warnings and precautions

Side effects

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FAQs

Download patent leaflet

Written By

Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Superintendant Pharmacist, Independent Prescriber

Checked By

Dr Sarah Thornton
MbChB, Coaching Academy diploma with distinction

GP, Medical coach

What are Rizatriptan 10mg Orodispersible Tablets?

Rizatriptan 10 mg Orodispersible Tablets are a type of medication used to treat acute migraine attacks. They contain the active ingredient rizatriptan, which is a member of the triptan class of drugs. Triptans are designed to specifically target and relieve migraine symptoms by acting on serotonin receptors in the brain.

Here’s what you need to know:

Form and Administration: These tablets are orodispersible, meaning they dissolve quickly in the mouth without the need for water. This can be particularly convenient for those who may have difficulty swallowing pills.
Purpose: Rizatriptan works by constricting dilated blood vessels in the brain and reducing inflammation, which helps alleviate migraine symptoms such as severe headache, nausea, and sensitivity to light and sound.
Usage: They are intended for use at the onset of a migraine attack. They do not prevent migraines but are effective in providing relief once symptoms begin.

Rizatriptan 10 mg Orodispersible Tablets are typically available by prescription and are suitable for use in adults experiencing migraine episodes.

What is the active ingredient in Rizatriptan 10mg Orodispersible Tablets?

Rizatriptan tablets contain the active ingredient:Rizatriptan benzoate 10 mg.

What are Rizatriptan 10mg Orodispersible Tablets used for?

Rizatriptan 10 mg Orodispersible Tablets are used to treat acute migraine attacks. They are designed to provide relief from the symptoms associated with migraines, which may include:

Severe headache or throbbing pain
Nausea or vomiting
Sensitivity to light and sound

The active ingredient, rizatriptan, belongs to a class of medications known as triptans. Triptans work by targeting serotonin receptors in the brain, which helps to reduce the dilation of blood vessels and alleviate the pain and other symptoms of a migraine attack. These tablets are specifically formulated to dissolve quickly in the mouth, making them convenient for immediate use, especially when water may not be readily available. They are intended for use during an active migraine attack and are not used for the prevention of migraines.

How do Rizatriptan 10mg Orodispersible Tablets work?

Rizatriptan 10 mg Orodispersible Tablets work by targeting the serotonin receptors in the brain. Here's how they operate:

Serotonin Receptor Activation: Rizatriptan is a triptan medication that stimulates specific serotonin receptors (5-HT1B and 5-HT1D receptors) in the brain.
Vasoconstriction: By activating these receptors, rizatriptan helps to constrict or narrow the dilated blood vessels in the brain, which are thought to contribute to migraine pain.
Pain Relief: This narrowing of blood vessels reduces the pressure and inflammation, leading to a decrease in the intensity of the migraine headache and alleviating associated symptoms such as nausea, sensitivity to light, and sound.
Rapid Dissolution: The orodispersible formulation allows the tablet to dissolve quickly on the tongue without the need for water, which facilitates faster absorption and quicker relief during an acute migraine attack.

These tablets are most effective when taken at the onset of a migraine attack and do not prevent future migraines but provide relief from the current episode.

How do you take Rizatriptan 10mg Orodispersible Tablets?

Rizatriptan is prescribed to treat migraine attacks. It should be taken as soon as you notice the onset of a migraine headache. It is not intended for the prevention of migraines. Always follow your doctor's instructions when taking Rizatriptan. If you are unsure about any aspect of its use, consult your doctor or pharmacist. Dosage Instructions:

The standard recommended dose is 10 mg.
Rizatriptan comes in the form of an orodispersible tablet that dissolves in your mouth.
To use, remove the tablet from its blister pack with dry hands and place it on your tongue. It will dissolve and can be swallowed with saliva.
This form is convenient when liquids are unavailable or to prevent nausea and vomiting that might occur with tablets taken with water.

Special Considerations:

If you are taking propranolol or have kidney or liver issues, use the 5 mg dose of Rizatriptan.
Maintain a gap of at least 2 hours between taking propranolol and Rizatriptan, and do not exceed 2 doses within a 24-hour period.

If Migraine Returns Within 24 Hours:

If symptoms reappear within 24 hours, you may take an additional dose of Rizatriptan. Ensure that you wait at least 2 hours between doses.
If the initial dose does not relieve the migraine, do not take a second dose for the same attack. It is likely that Rizatriptan will work during a subsequent migraine attack.

Maximum Dosage:

Do not take more than 2 doses of Rizatriptan within a 24-hour period. This equates to a maximum of 20 mg in total.
Always allow at least 2 hours between doses.

Overdose:

If you accidentally take more Rizatriptan than prescribed, contact your doctor or pharmacist immediately. Bring the medicine pack with you.
Symptoms of overdose may include dizziness, drowsiness, vomiting, fainting, and a slow heart rate.

If you have further questions about using Rizatriptan, please consult your doctor or pharmacist.

Who should not take Rizatriptan 10mg Orodispersible Tablets?

Do not take Rizatriptan if you:

Are allergic to rizatriptan benzoate or any other ingredients in this medicine, please refer to the patient information leaflet.
Have moderately severe or severe high blood pressure, or mild high blood pressure that is not controlled by medication.
Have a history of heart problems, including heart attack, angina (chest pain), or other heart-related issues.
Suffer from severe liver or kidney problems.
Have had a stroke (cerebrovascular accident) or a mini-stroke (transient ischemic attack).
Experience reduced blood flow to your limbs due to blocked arteries (peripheral vascular disease).
Are currently taking monoamine oxidase (MAO) inhibitors such as moclobemide, phenelzine, tranylcypromine, or pargyline, or the antibiotic linezolid, or if it has been less than two weeks since stopping MAO inhibitors.
Are using ergotamine-type medications, such as ergotamine or dihydroergotamine, or methysergide for migraine treatment or prevention.
Are taking other triptans, such as sumatriptan, naratriptan, or zolmitriptan, for migraine treatment.

If you are unsure whether any of these conditions apply to you, consult your doctor or pharmacist before using Rizatriptan. Warnings and Precautions:

Talk to your doctor or pharmacist if you have risk factors for heart disease, such as high blood pressure, diabetes, smoking, nicotine use, a family history of heart disease, being a man over 40, or a post-menopausal woman.
Consult your doctor if you have kidney or liver problems.
Inform your doctor if you have heart rhythm issues like bundle branch block, allergies, or if your headache is accompanied by dizziness, difficulty walking, lack of coordination, or weakness in your limbs.
If you use herbal remedies containing St. John's Wort.
Notify your doctor if you have had allergic reactions such as swelling of the face, lips, tongue, or throat, which may cause breathing or swallowing difficulties (angioedema).
Inform your doctor if you are taking selective serotonin reuptake inhibitors (SSRIs) like sertraline, escitalopram, or fluoxetine, or serotonin norepinephrine reuptake inhibitors (SNRIs) like venlafaxine or duloxetine.
Seek medical advice if you have had brief symptoms including chest pain and tightness.

Important Notes:

Overuse of Rizatriptan may lead to chronic headaches. If this occurs, consult your doctor, as you may need to stop using the medication.
Rizatriptan should only be used for treating migraine attacks and not for other types of headaches or more serious conditions.

Children and Adolescents:

Rizatriptan is not recommended for children and adolescents under 18 years due to a lack of experience with this age group.

Patients Over 65 Years:

There is limited information on the safety and effectiveness of Rizatriptan in individuals over 65 years of age.

Food and Drink:

Rizatriptan may take longer to work if taken after food. It is ideally taken on an empty stomach, but it can still be effective if taken after eating.

Pregnancy, Breastfeeding, and Fertility:

If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor or pharmacist before taking Rizatriptan.
Data suggest no increased risk of birth defects during the first trimester of pregnancy, but the effects of taking Rizatriptan later in pregnancy are not fully known.
If breastfeeding, consider postponing for 12 hours after treatment to avoid passing the medicine to your baby.

Driving and Using Machines:

Rizatriptan may cause drowsiness or dizziness. If affected, avoid driving or operating machinery.

Aspartame Warning:

Rizatriptan contains aspartame (E951), which includes phenylalanine. This may be harmful to individuals with phenylketonuria.

What are the side effects with Rizatriptan 10mg Orodispersible Tablets?

Possible Side Effects of Rizatriptan Like all medications, Rizatriptan may cause side effects, though not everyone will experience them. Below are potential side effects associated with this medicine: Immediate Medical Attention:

Seek prompt medical help if you experience symptoms of an allergic reaction, serotonin syndrome, heart attack, or stroke.
Also, inform your doctor if you develop any signs of an allergic reaction, such as a rash or itching.

Common Side Effects (may affect up to 1 in 10 people):

Tingling (paresthesia), headache, reduced skin sensitivity (hypoesthesia), decreased mental sharpness, insomnia.
Fast or irregular heartbeat (palpitations).
Temporary facial redness (flushing).
Throat discomfort.
Nausea, dry mouth, vomiting, diarrhea, indigestion (dyspepsia).
Feeling of heaviness in body parts, neck pain, stiffness.
Abdominal or chest pain.

Uncommon Side Effects (may affect up to 1 in 100 people):

Unpleasant taste in the mouth.
Unsteadiness (ataxia), dizziness (vertigo), blurred vision, tremors, fainting (syncope).
Confusion, nervousness.
High blood pressure (hypertension), thirst, hot flushes, sweating.
Rash, itching, hives, swelling of the face, lips, tongue, and/or throat which may lead to breathing or swallowing difficulties (angioedema), difficulty breathing (dyspnea).
Muscle weakness, tightness in body parts.
Irregular heartbeat (arrhythmia), abnormal electrocardiogram results, very rapid heartbeat (tachycardia).
Facial pain, muscle pain.

Rare Side Effects (may affect up to 1 in 1,000 people):

Wheezing.
Allergic reactions (hypersensitivity), including severe, life-threatening allergic reactions (anaphylaxis).
Stroke (typically in individuals with risk factors for heart and blood vessel disease such as high blood pressure, diabetes, smoking, nicotine use, family history of heart disease or stroke, men over 40 years of age, post-menopausal women, or specific heart rhythm issues).
Slow heartbeat (bradycardia).

Not Known (frequency cannot be estimated from available data):

Heart attack, spasm of heart blood vessels (usually in patients with risk factors for heart and blood vessel disease).
Serotonin syndrome, which may cause severe side effects like coma, unstable blood pressure, extremely high body temperature, muscle coordination issues, agitation, and hallucinations.
Severe skin shedding with or without fever (toxic epidermal necrolysis).
Seizures (convulsions/fits).
Spasm of blood vessels in extremities, leading to coldness and numbness in hands or feet.
Spasm of blood vessels in the colon, causing abdominal pain.

Reporting Side Effects: If you experience any side effects, consult your doctor or pharmacist, including those not listed here. You can also report side effects directly via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard. Reporting side effects helps improve the safety information for this medicine.

Do Rizatriptan 10mg Orodispersible Tablets interact with other medicines?

Inform Your Doctor or Pharmacist:

If you are currently taking, have recently taken, or plan to take any other medicines, including those obtained without a prescription, herbal remedies, or migraine treatments. This is important because Rizatriptan can influence how some medicines work, and other medicines can affect Rizatriptan's effectiveness.

Do not take Rizatriptan if:

You are currently using a 5HT1B/1D agonist (often called ‘triptans’), such as sumatriptan, naratriptan, or zolmitriptan.
You are taking a monoamine oxidase (MAO) inhibitor like moclobemide, phenelzine, tranylcypromine, linezolid, or pargyline, or if it has been less than two weeks since you stopped using an MAO inhibitor.
You use ergotamine-type medications, such as ergotamine or dihydro-ergotamine, for migraine treatment.
You use methysergide to prevent migraine attacks.

Combining these medications with Rizatriptan may increase the risk of side effects. Timing for Taking Other Medicines:

Wait at least 6 hours after taking Rizatriptan before using ergotamine-type medicines (e.g., ergotamine or dihydro-ergotamine) or methysergide.
Wait at least 24 hours after using ergotamine-type medicines before taking Rizatriptan.

Consult Your Doctor Regarding:

Propranolol (refer to section 3: How to Take Rizatriptan).
SSRIs (e.g., sertraline, escitalopram oxalate, fluoxetine) or SNRIs (e.g., venlafaxine, duloxetine) for depression.

Rizatriptan 10mg Orodispersible Tablets FAQs

What is Rizatriptan and what is it used for?

Rizatriptan, the generic name for Maxalt Wafers, is prescribed to treat migraine headaches. It is a 5HT1 agonist that works by reducing blood vessel swelling in the brain by targeting serotonin receptors. Each box of Rizatriptan 10mg contains six orodispersible tablets that dissolve quickly on the tongue, making them suitable for those who prefer not to swallow large tablets.

What is a migraine?

The exact cause of migraines is not fully understood, though they are often linked to changes in brain chemicals. They may also be triggered by certain foods or drinks. Migraines are common, particularly among women, and can be hereditary. Symptoms can include severe headache, nausea, light sensitivity, and more. Some people experience warning signs known as an aura before the migraine starts.

How does Rizatriptan work?

Rizatriptan is a 5HT1-receptor agonist, also known as a triptan. It works by stimulating serotonin in the brain to relieve the headache associated with migraines. It is most effective when taken at the first sign of a migraine. Do not take other triptans or ergotamine while using Rizatriptan.

Are there alternatives to Rizatriptan?

Yes, there are several alternatives for migraine treatment. At medicalmojo.co.uk, you can find both prescription and over-the-counter options. Your doctor might also recommend non-steroidal anti-inflammatory drugs (NSAIDs) like naproxen. Over-the-counter options include paracetamol, ibuprofen, aspirin, and Migraleve.

How should I take Rizatriptan?

Take Rizatriptan as soon as you notice a migraine beginning. Place one tablet on your tongue and let it dissolve completely. If the medication does not work, wait at least 2 hours before taking a second dose. Do not exceed 2 tablets in a 24-hour period. If you are on propranolol or have liver or kidney issues, use the 5mg dose of Rizatriptan and maintain at least a 2-hour gap between propranolol and Rizatriptan.

What warnings should I be aware of?

Do not use Rizatriptan if you are allergic to any of its ingredients, have high blood pressure, a history of heart attack or stroke, severe liver or kidney problems, or are on MAO inhibitors. Consult your doctor if you have high risk for heart disease, issues with heart rhythm, are taking St. John's Wort, or are on SSRIs or SNRIs. Read the packaging and Patient Information Leaflet carefully before use.

What are the ingredients in Rizatriptan?

Each Rizatriptan tablet contains 10 mg of Rizatriptan benzoate. Inactive ingredients include mannitol (E421), microcrystalline cellulose (E460a), crospovidone type A, aspartame (E951), magnesium stearate (E572), colloidal silicon dioxide, and peppermint flavor.

What side effects might I experience?

Possible side effects of Rizatriptan include dizziness, tiredness, tingling, additional headache, difficulty sleeping, heart palpitations, flushing, sore throat, nausea, neck pain, decreased skin sensitivity, aches, and abdominal pain. If you experience any concerning side effects, stop using the medication and consult your doctor or pharmacist.

Download patient leaflet

https://www.medicines.org.uk/emc/files/pil.9894.pdf

Checked By

Dr Sarah Thornton
MbChB, Coaching Academy diploma with distinction

GP, Medical coach

Written By

Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Superintendant Pharmacist, Independent Prescriber

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