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Tadalafil 20mg tablets

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Tadalafil 20mg is a prescription medication used to treat erectile dysfunction (ED) by enhancing blood flow to the penis, helping to achieve and maintain an erection during sexual activity. Known for its long-lasting effects, tadalafil can work for up to 36 hours, offering flexibility and spontaneity. It is effective when taken as needed, typically 30 minutes before sexual activity, and is suitable for most adult men. Tadalafil 20mg provides a reliable solution for those seeking to improve their sexual health and performance.

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Overview

Active ingredients

What is it for?

How does it work?

How do you use it?

Warnings and precautions

Side effects

Drug interactions

FAQs

Download patent leaflet

Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Independent prescriber, Superintendent pharmacist.


Checked By
Dr Sarah Thornton
MbChB, Coaching Academy diploma with distinction

Medical coaching


August 11, 2024
August 11, 2026

What are Tadalafil 20mg tablets?

Tadalafil 20mg tablets are a low-dose formulation of tadalafil, a phosphodiesterase type 5 (PDE5) inhibitor used primarily for the treatment of erectile dysfunction (ED) and benign prostatic hyperplasia (BPH). By inhibiting PDE5, tadalafil helps to relax the blood vessels in the penis, increasing blood flow and enabling an erection in response to sexual stimulation. Additionally, it alleviates urinary symptoms associated with BPH by relaxing the smooth muscles in the prostate and bladder.

Tadalafil 20mg tablets are used primarily to treat erectile dysfunction (ED) by enhancing blood flow to the penis. The onset of action for Tadalafil 20mg typically occurs within 30 to 60 minutes after oral administration. It is recommended to take the tablet at least 30 minutes before planned sexual activity. One of the distinctive features of tadalafil is its prolonged duration of action compared to other ED medications. The effects can last up to 36 hours, allowing for greater spontaneity in sexual activity. This extended duration is due to tadalafil’s longer half-life, providing an effective therapeutic window that is often referred to as the “weekend pill.” However, sexual stimulation is still required to achieve an erection. The long duration of action makes tadalafil a preferred choice for many men, offering flexibility and reducing the need to time the medication precisely before sexual activity.

Tadalafil 20mg tablets are typically well-tolerated, with common side effects including headache, indigestion, back pain, and muscle aches, which usually diminish with continued use. As with any medication, it is important to use tadalafil under the guidance of a healthcare provider to ensure its safety and efficacy, especially for individuals with underlying health conditions or those taking other medications.

What is the active ingredient in Tadalafil 20mg tablets?

Each tablet contains Tadalafil 20mg tablets.

What are Tadalafil 20mg tablets used for?

Tadalafil is the generic version of the erectile dysfunction medication, Cialis. Tadalafil or Cialis is a prescription medication that is used to treat erectile dysfunction, which is a condition that affects a man's ability to achieve or maintain an erection. When taken in conjunction with sexual stimulation, Cialis works by increasing blood flow to the penis, allowing a man to obtain and sustain an erection. The effects of Cialis can last for up to 36 hours. It is important to note that Cialis is not an aphrodisiac and does not increase sexual desire. It is only intended to help men with ED achieve and maintain an erection when they are sexually aroused.

How do Tadalafil 20mg tablets work?

All prescription pills like Viagra, sildenafil, Cialis and tadalafil work blocking an enzyme phosphodiesterase type 5 which allows more Nitric Oxide (NO) to build up. So, when it comes to ED treatment, remember just say NO! By allowing the build up of NO in the blood vessels of the penis allows more blood to flood in. Tadalafil, therefore, works in the exact same way as sildenafil, so what’s the difference? The difference is their duration of action.

How to take Tadalafil 20mg tablets?

Cialis is available in four strengths: 2.5mg, 5mg, 10mg, and 20mg. The lower doses of 2.5mg and 5mg are primarily intended for daily use, although the 5mg dose can be taken as needed by men who respond well to one-time lower doses. The starting dose of Cialis is usually 10mg, which should be taken at least 30 minutes before sexual activity. If this dose is effective, the dosage can be reduced to 5mg on a trial basis. If multiple trials of a 10mg dose prove ineffective, the dosage may be increased to 20mg. It is important to note that there is no advantage to taking a higher dose of Cialis than is necessary, and it is recommended to try treatment at one dose before adjusting to a higher or lower-strength tablet.

Who cannot take Tadalafil 20mg tablets?

During an assessment on the Medicalmojo.co.uk platform, men are asked to complete a questionnaire about their erectile dysfunction to determine if Cialis is suitable for them. It is not recommended for men to take Cialis without further assessment from their healthcare provider if any of the following apply:
  • They are already taking other ED medications such as Viagra, Levitra, or Spedra
  • They are currently taking nitrates for angina, including isosorbide mononitrate, isosorbide dinitrate, nicorandil, and glyceryl trinitrate (serious reactions are possible)
  • They are taking medications to treat HIV, including Indinavir and Ritonavir
  • They are using anti-fungal treatments like itraconazole or ketoconazole
  • They are using recreational drugs like amyl nitrate ("poppers")
  • They are taking alpha-blockers often used to treat prostate enlargement and high blood pressure such as doxazosin, prazosin, alfuzosin, terazosin, indoramin, and tamsulosin
  • They are taking antibiotics like erythromycin, clarithromycin, or rifampicin
  • They are taking anticonvulsants like phenobarbital, phenytoin, or carbamazepine

What are the Side Effects of Tadalafil 20mg tablets?

In addition to blocking the phosphodiesterase enzyme associated with erectile dysfunction, Cialis or tadalafil also blocks another phosphodiesterase enzyme as well, sometimes resulting in temporary visual changes, making things look blue… just like the pill! This is a common side effect of all PDE5 inhibitors and is not dangerous. Other common side effects (affecting 1%-10% of people) include:
  • Headache
  • Runny nose
  • Indigestion
  • Nasal congestion
  • Back pain
  • Muscle aches
  • Pain in the arms and legs
  • Facial flushing
Most men do not experience significant side effects when taking Cialis. A complete list of common side effects can be found in the patient information leaflet provided by the manufacturer. Some men may experience a bluish or yellowish tinge to their vision after taking Cialis, which is a common side effect of all PDE5 inhibitors and is not dangerous. On very rare occasions, ED treatment can cause prolonged and painful erections, a condition known as priapism. Priapism is a medical emergency that can lead to irreversible injury to the penis if not treated promptly. If an erection lasts for more than 2 hours, it is important to seek medical attention immediately.

Drug Interactions with Tadalafil 20mg tablets 

Tadalafil 20mg tablets can interact with several other medications, potentially leading to adverse effects or reduced efficacy. It is important to inform your healthcare provider of all medications you are currently taking, including prescription, over the counter, and herbal supplements. Key interactions include:
  1. Nitrates:
    • Tadalafil can cause a significant drop in blood pressure when taken with nitrates, which are commonly prescribed for chest pain (angina). This combination is contraindicated.
  2. Alpha-blockers:
    • Used to treat high blood pressure or prostate conditions, alpha-blockers (e.g., doxazosin, tamsulosin) can enhance the blood pressure-lowering effects of tadalafil. Caution and dose adjustments may be necessary.
  3. Antihypertensives:
    • When combined with blood pressure medications, tadalafil may potentiate the blood pressure-lowering effects, requiring careful monitoring and potential dose adjustments.
  4. Antifungal medications:
    • Drugs like ketoconazole and itraconazole can increase tadalafil levels in the blood, increasing the risk of side effects. Dose adjustments or alternative treatments may be needed.
  5. HIV Protease Inhibitors:
    • Medications such as ritonavir can elevate tadalafil levels in the blood, necessitating dose modifications to avoid adverse effects.
  6. Antibiotics:
    • Certain antibiotics like erythromycin can raise tadalafil levels, requiring careful monitoring and potential dose changes.
  7. Other PDE5 Inhibitors:
    • Concurrent use of tadalafil with other PDE5 inhibitors (e.g., sildenafil, vardenafil) is not recommended due to the increased risk of side effects.
  8. Grapefruit Juice:
    • Grapefruit juice can interfere with the metabolism of tadalafil, leading to higher blood levels and increased risk of side effects.
  9. Antacids:
    • Some antacids can affect the absorption of tadalafil, potentially altering its efficacy. It is advisable to take antacids and tadalafil at different times.
  10. Alcohol:
    • Excessive alcohol consumption can increase the likelihood of experiencing side effects like dizziness, headache, and lowered blood pressure.
It is crucial to manage these interactions under the supervision of a healthcare provider to ensure safe and effective use of Tadalafil 20mg  tablets tablets tablets.

Tadalafil 20mg tablets FAQs

What is Tadalafil 20mg tablets?

In the UK, the patent for Cialis expired on November 14, 2017. This means that other pharmaceutical companies are now able to produce and sell generic versions of the medication, which are known as tadalafil. Generic medications are identical to their branded counterparts in terms of safety, quality, and effectiveness, but they are typically much less expensive.

What do Tadalafil 20mg tablets do?

Cialis contains the active ingredient tadalafil, which is a type of medication known as a PDE5 inhibitor. PDE5 inhibitors work by inhibiting the PDE5 enzyme, which is involved in regulating blood flow to the penis during an erection. Tadalafil is taken orally and requires sexual stimulation to be effective. In addition to its use in treating erectile dysfunction, tadalafil can also be used to alleviate the symptoms of benign prostatic hyperplasia (BPH), which is a condition characterized by an enlarged prostate gland. Cialis can help to improve sexual performance and enhance relationships.

Why do some men get Erectile Dysfunction?

There are many factors that can contribute to erectile dysfunction (ED), including lifestyle choices, mental health, and underlying medical conditions. Emotional issues such as stress and performance anxiety can affect both erectile function and sexual desire. Taking a PDE5 inhibitor like Cialis on an occasional basis can be effective in breaking the cycle of anxiety and failure. Lifestyle habits such as smoking, drug use, excessive alcohol consumption, and obesity can also contribute to ED. In some cases, ED may be a symptom of a more serious underlying health condition, such as diabetes, atherosclerosis, or heart disease. Men who are experiencing ED should consult with their healthcare provider, who can assess their condition and provide appropriate treatment and advice.

How long do Tadalafil 20mg tablets last for?

Cialis or tadalafil has the advantage that it is effective for a day and half. In comparison, Viagra or sildenafil, is effective for about four hours. Because Cialis (tadalafil) lasts so long, it can be taken as a low dose once a day, with the level in your body increasing steadily over the first 5 days, then settling out. This helps to make up you ‘ready for action’ any time.

What are the benefits of Tadalafil 20mg tablets?

It has been discovered that taking low daily dosing of Cialis or Tadalafil helps with urination symptoms due to an enlarged prostate, such as weak flow, frequent urination, and waking up at night to urinate.

Can I take Tadalafil 20mg tablets daily?

Tadalafil is available as a 2.5mg or 5mg tablet for daily dosing and a 10mg and 20mg tablet for on-demand dosing.

How to take Tadalafil for the first time?

Cialis is available in four strengths: 2.5mg, 5mg, 10mg, and 20mg. The lower doses of 2.5mg and 5mg are primarily intended for daily use, although the 5mg dose can be taken as needed by men who respond well to one-time lower doses. The starting dose of Cialis is usually 10mg, which should be taken at least 30 minutes before sexual activity. If this dose is effective, the dosage can be reduced to 5mg on a trial basis. If multiple trials of a 10mg dose prove ineffective, the dosage may be increased to 20mg. It is important to note that there is no advantage to taking a higher dose of Cialis than is necessary, and it is recommended to try treatment at one dose before adjusting to a higher or lower-strength tablet.

Daily Dosing versus On-Demand Dosing

Cialis is typically taken as needed, usually in a dosage of 10mg or 20mg, which is effective for up to 36 hours. Men who need treatment for erectile dysfunction on a regular basis (two or more times per week) may find it beneficial to take a lower dose of Cialis daily. The 2.5mg or 5mg strength tablets can be taken daily to provide continuous treatment for ED without the need to take a pill before sexual activity. This can help to alleviate the "peaks and troughs" that can be associated with taking medication on an as-needed basis.

How long does it take for Tadalafil to work?

On-demand dosing starts working in up to 2 hours and is effective for 36 hours. While daily dosing works in up to 5 days, after which time it is always in effect.

Does Tadalafil work all the time?

The response to Cialis treatment is usually consistent and predictable. If Cialis has been effective for a person in the past, it is likely to be effective again. However, some causes of ED, such as physical injuries or nerve damage, may not respond well to tablet treatment and may require alternative therapies like injections or penile implants. Some men with ED may benefit from counselling if the cause of their ED is psychological. It is important for all men who are experiencing ED, which can be a distressing issue, to consult with a healthcare provider for a full assessment and advice on treatment options.

Why take Tadalafil?

One of the benefits of Tadalafil is that it has a long duration of action compared to other ED medications. Viagra remains effective for about 4 hours, while Levitra is effective for 4-5 hours. Cialis, on the other hand, is effective for up to 36 hours, which is why it is sometimes referred to as "The Weekend Pill." It's important to note that Cialis does not cause continuous erections for 36 hours, but rather allows a man to achieve an erection when sexually stimulated within that time frame. Erections will only occur at times of arousal during the 36 hours after taking the medication.

 What is the Weekend Pill?

Cialis or Tadalafil is a medication used to treat erectile dysfunction (ED) that is produced by the pharmaceutical company Lilly. It is sometimes referred to as "The Weekend Pill" because it is effective for up to 36 hours. Cialis was first licensed for use in the UK in 2003, making it the second ED medication to receive such a license after Viagra. It has gained popularity due to its prolonged effectiveness and the availability of a low-dose daily tablet. As a result, it is prescribed more frequently by healthcare providers. Cialis is a medication used to treat erectile dysfunction (ED) in men. It works by relaxing the muscles in the blood vessels of the penis, allowing blood to flow more easily and causing an erection. Cialis is available in both branded and generic forms and can be obtained with a prescription from a healthcare provider. Medicalmojo.co.uk offers both Cialis and Viagra, another medication used to treat ED, for purchase online with the option of obtaining a prescription through their prescription service. Cialis is typically used by middle-aged men but can be effective for men of any age who are experiencing ED.

Where to buy Tadalafil 20mg tablets?

Medicalmojo.co.uk is a reliable online medical platform that offers the option to purchase both generic Tadalafil and branded Cialis. If you already have a prescription, medicalmojo.co.uk can fill it and offer overnight shipping on most days of the week. If you do not have a prescription for Cialis, their online doctor service may be able to assist you in obtaining one.  

Download patient leaflet

https://www.medicines.org.uk/emc/files/pil.9363.pdf

Checked By
Dr Sarah Thornton
MbChB, Coaching Academy diploma with distinction

Medical coaching


August 11, 2026
Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Independent prescriber, Superintendent pharmacist.


August 11, 2024

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