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Zolmitriptan 2.5mg Tablets

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Zolmitriptan is a prescription medication used to treat acute migraine attacks. It belongs to a class of drugs known as triptans, which work by constricting the widened blood vessels in the brain that cause migraine pain. Zolmitriptan provides rapid relief from migraine symptoms, including headache, nausea, and sensitivity to light and sound. It is typically taken at the onset of a migraine or during an attack. Available in tablet form, Zolmitriptan is intended for adults between the ages of 18 and 65.

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Zolmitriptan 2.5mg Tablets
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Overview

Active ingredients

What is it for?

How does it work?

How do you use it?

Warnings and precautions

Side effects

Drug interactions

FAQs

Download patent leaflet

Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Independent prescriber, Superintendent pharmacist.


Checked By
Dr Sarah Thornton
MbChB, Coaching Academy diploma with distinction

Medical coaching


What is Zolmitriptan 2.5mg?

Zolmitriptan is a medication used to treat migraine headaches and is part of the triptan class of drugs. Available in film-coated tablets, it works by targeting the blood vessels in the brain. Migraines are often caused by the expansion of these blood vessels, and Zolmitriptan helps alleviate this by constricting them. This action helps relieve the headache and other associated symptoms, such as nausea, vomiting, and sensitivity to light and sound. It’s important to note that Zolmitriptan is effective only once a migraine has begun and does not prevent future migraine attacks.

What is the active ingredient in Zolmitriptan 2.5mg?

The active ingredient in each Zolmitriptan tablet is: Zolmitriptan 2.5 mg.

What is Zolmitriptan 2.5mg used for?

Zolmitriptan 2.5mg is used for the acute treatment of migraine attacks. It is part of the triptan class of medications and works by constricting the blood vessels in the brain that are often enlarged during a migraine. This helps alleviate migraine symptoms such as headache, nausea, and sensitivity to light and sound. Zolmitriptan 2.5mg is intended to be taken at the onset of a migraine to provide relief and does not prevent future migraines from occurring.

How does Zolmitriptan 2.5mg work?

Zolmitriptan 2.5mg works by targeting the underlying mechanisms of a migraine attack. Specifically:
  1. Vessel Constriction: Zolmitriptan is a triptan that binds to serotonin receptors in the brain. This action helps constrict the dilated blood vessels that are often responsible for the throbbing headache associated with migraines.
  2. Chemical Stabilization: It stabilizes the levels of certain brain chemicals involved in the migraine process, reducing the inflammation and neurochemical disturbances that contribute to migraine symptoms.
  3. Symptom Relief: By addressing both the vascular and neurochemical components of a migraine, Zolmitriptan helps alleviate symptoms such as headache, nausea, and sensitivity to light and sound.
Zolmitriptan 2.5mg is most effective when taken as soon as migraine symptoms begin. It is designed to relieve symptoms during an attack and does not prevent migraines from occurring.  

How do you use Zolmitriptan 2.5mg?

Follow your doctor’s or pharmacist’s instructions carefully when using Zolmitriptan Film-coated Tablets. If you’re unsure, consult them for guidance. You can take Zolmitriptan as soon as you notice a migraine headache or once the attack has started.
  • Dosage: The recommended dose is one tablet of 2.5 mg or 5 mg.
  • Administration: Swallow the tablet with a drink of water.
  • Additional Dose: If symptoms persist after two hours or return within 24 hours, you may take a second tablet. Do not exceed the prescribed dose.
Important Considerations:
  • Maximum Daily Dose: Do not exceed two doses in one day unless directed by your doctor. The maximum daily dose is 10 mg.
  • Elderly Adults: Zolmitriptan is not recommended for individuals over 65 years of age.
  • Children and Adolescents: Not recommended for those under 18 years old.
If You Take Too Much: If you accidentally take more Zolmitriptan than prescribed, contact your doctor or go to the nearest hospital immediately. Bring the medication with you. If You Miss a Dose: Do not take a double dose to compensate for a missed one. For any additional questions about using this medication, consult your doctor or pharmacist.
 
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Who should not use Zolmitriptan 2.5mg?

Do not use Zolmitriptan Film-coated Tablets if:
  • You are allergic to zolmitriptan or any other ingredients in this medicine, please refer to patient information leaflet.
  • You have high blood pressure.
  • You have a history of heart problems, including heart attacks, angina (chest pain from exertion), Prinzmetal's angina (resting chest pain), or symptoms like shortness of breath or chest pressure.
  • You have had a stroke or transient ischaemic attack (TIA), which are similar to strokes.
  • You are currently taking other migraine treatments such as ergotamine or ergot-type medications (like dihydroergotamine and methysergide), or other triptans. Refer to the section on 'Other medicines and Zolmitriptan Film-coated Tablets' for more information.
If any of these conditions apply to you, do not take Zolmitriptan Film-coated Tablets. Consult your doctor or pharmacist if you are unsure. Warnings and Precautions Consult your doctor or pharmacist before using Zolmitriptan Film-coated Tablets if:
  • You are at risk for ischaemic heart disease (poor blood flow to the heart). Risk factors include smoking, high blood pressure, high cholesterol, diabetes, or a family history of ischaemic heart disease.
  • You have Wolff-Parkinson-White Syndrome (a type of irregular heartbeat).
  • You have or have had liver problems.
  • Your headaches differ from your usual migraines.
  • You are taking other medications for depression. See the 'Other medicines and Zolmitriptan Film-coated Tablets' section for details.
  • You are using herbal remedies containing St John’s Wort (used for depression).
  • You are going to a hospital, inform the medical staff that you are taking Zolmitriptan Film-coated Tablets.
Zolmitriptan Film-coated Tablets are not recommended for those under 18 or over 65 years old. Taking too much Zolmitriptan Film-coated Tablets can lead to daily headaches or worsen your migraines. Inform your doctor if you think this might be an issue, as you may need to stop the medication. Food and Drink Zolmitriptan Film-coated Tablets can be taken with or without food, as it does not affect how the medication works. Pregnancy, Breastfeeding, and Fertility
  • Pregnancy: The effects of zolmitriptan during pregnancy are not fully known. Inform your doctor if you are pregnant or planning to become pregnant before taking this medication.
  • Breastfeeding: Zolmitriptan may pass into breast milk. To minimize risk, avoid breastfeeding for 24 hours after taking zolmitriptan.
Driving and Using Machines During a migraine, your reactions may be slower. Use caution when driving or operating machinery. Zolmitriptan Film-coated Tablets are unlikely to impair your ability to drive or use machinery, but they may cause drowsiness. Assess how the medication affects you before engaging in these activities. Lactose Content Zolmitriptan 2.5 mg/5 mg Film-coated Tablets contain lactose. If you have been advised to avoid certain sugars due to intolerance, consult your doctor before taking this medicine.

What are the side effects with Zolmitriptan 2.5mg?

Like all medications, Zolmitriptan Film-coated Tablets can cause side effects, although not everyone experiences them. Some symptoms listed below might also be related to the migraine itself. Stop taking Zolmitriptan Film-coated Tablets and contact your doctor immediately if you experience: Rare Side Effects (affecting up to 1 in 1,000 people):
  • Allergic reactions, such as itchy rash (urticaria) and swelling of the face, lips, mouth, tongue, or throat.
Very Rare Side Effects (affecting up to 1 in 10,000 people):
  • Chest pain (angina), heart attack, or spasm of the heart’s blood vessels, which may include chest pain and shortness of breath.
  • Spasm of the blood vessels in the gut, potentially causing stomach pain or bloody diarrhea.
  • Bleeding in the brain (cerebral bleeding) or stroke.
Other Possible Side Effects: Common Side Effects (affecting up to 1 in 10 people): These are usually mild and tend to resolve on their own.
  • Abnormal sensations like tingling in fingers and toes or sensitive skin.
  • Drowsiness, dizziness, or feeling warm.
  • Headache.
  • Irregular heartbeat.
  • Nausea or vomiting.
  • Stomach pain.
  • Dry mouth.
  • Muscle weakness or pain.
  • Feeling generally weak.
  • Sensations of heaviness, tightness, pain, or pressure in the throat, neck, arms, legs, or chest.
  • Difficulty swallowing.
Uncommon Side Effects (affecting up to 1 in 100 people):
  • Rapid heartbeat.
  • Slight increase in blood pressure.
  • Increase in urine output or frequency.
Very Rare Side Effects (affecting 1 in 10,000 people):
  • Sudden, urgent need to urinate.
Reporting Side Effects: If you experience any side effects, consult your doctor or pharmacist, including any not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard. Reporting helps to provide more information on the safety of this medication.

Does Zolmitriptan 2.5mg interact with other medicines?

Inform your doctor or pharmacist if you are currently taking, have recently taken, or plan to take any other medications, including those obtained without a prescription or any herbal remedies. In particular, make sure to tell your doctor if you are using: Medications for Migraine:
  • If you are taking a different triptan (such as sumatriptan or naratriptan), wait 24 hours before starting Zolmitriptan Film-coated Tablets.
  • After taking Zolmitriptan Film-coated Tablets, wait 24 hours before using another triptan.
  • If you use medications containing ergotamine or ergot-type drugs (like dihydroergotamine or methysergide), wait 24 hours before taking Zolmitriptan Film-coated Tablets.
  • After taking Zolmitriptan Film-coated Tablets, wait 6 hours before using ergotamine or ergot-type medications.
Medications for Depression:
  • Monoamine Oxidase Inhibitors (MAOIs), such as moclobemide.
  • Selective Serotonin Reuptake Inhibitors (SSRIs), such as fluoxetine, paroxetine, fluvoxamine, or sertraline.
  • Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs), such as venlafaxine or duloxetine.
Other Medications:
  • Cimetidine (for indigestion or stomach ulcers).
  • A quinolone antibiotic (such as ciprofloxacin).
If you are using herbal remedies containing St John’s Wort (Hypericum perforatum), be aware that it may interact with Zolmitriptan Film-coated Tablets. Discontinue use and inform your doctor if you experience any issues.

Zolmitriptan 2.5mg FAQs

What is Zolmitriptan and what is it used for?

Zolmitriptan 2.5 mg Tablets are used to effectively relieve migraine attacks. The active ingredient, zolmitriptan, is a type of medication known as a triptan. Triptans are designed to target migraines and alleviate symptoms by reducing inflammation of the blood vessels in the brain. Each box contains 6 tablets and is available by prescription for adults aged 18 to 65 years.

What is a migraine?

In the UK, migraines affect about 25% of women and 8% of men. They can be hereditary, meaning if a relative suffers from migraines, you might be more prone to them. Triggers for migraines can include poor diet, excessive alcohol consumption, too much caffeine, stress, lack of sleep, or menstrual cycles. Migraines can severely disrupt daily life with symptoms such as nausea, light sensitivity, intense throbbing pain, and heightened intolerance to noises and smells. A migraine may last a few hours to three days, and post-migraine fatigue can last several days.

How does Zolmitriptan work?

Zolmitriptan works by targeting the widening of blood vessels in the brain, which is thought to cause the throbbing pain of migraines. It belongs to a group of medications called serotonin agonists that stimulate serotonin receptors in the brain to narrow these blood vessels, thereby relieving pain. For best results, take Zolmitriptan at the onset of a migraine or during an attack. It does not prevent migraines but can be used alongside other preventative treatments.

What are some alternative over-the-counter medications for migraines?

Over-the-counter medications that can help with migraine pain and nausea include:
  • Paracetamol
  • Ibuprofen
  • Aspirin
  • Migraleve
For more information about available treatments, visit our Advice for Migraines page.

What should I know about taking Zolmitriptan?

Always follow your doctor's or pharmacist's instructions when taking Zolmitriptan. You should take it as soon as a migraine starts or during an attack. The typical dose is one 2.5 mg tablet swallowed with water. If symptoms persist after two hours or return within 24 hours, you may take a second tablet. Do not exceed more than two doses in one day, and the maximum daily dose is 10 mg.

What are the ingredients in Zolmitriptan?

Each Zolmitriptan tablet contains 2.5 mg of zolmitriptan. The inactive ingredients include lactose anhydrous, microcrystalline cellulose, sodium starch glycolate type A, magnesium stearate, hypromellose, titanium dioxide (E 171), macrogol 400, macrogol 8000, and iron oxide yellow (E172).

What side effects might I experience with Zolmitriptan?

Common side effects, which are usually mild and temporary, include tingling sensations, drowsiness, dizziness, warmth, headache, irregular heartbeat, nausea or vomiting, stomach pain, dry mouth, muscle weakness or pain, and sensations of heaviness or pressure. If you experience any of these or other concerning effects, consult your doctor or pharmacist.

What warnings should I be aware of before taking Zolmitriptan?

Do not take Zolmitriptan if you are allergic to it or any of its ingredients, have high blood pressure, or have a history of heart problems or stroke. It should not be used with other migraine medications such as ergotamine or other triptans. Consult your doctor if you smoke, have high cholesterol, diabetes, a family history of ischaemic heart disease, liver problems, or are taking antidepressants or herbal remedies containing St John’s Wort.

What should I know about Zolmitriptan during pregnancy and breastfeeding?

If you are pregnant, breastfeeding, or planning to become pregnant, consult your doctor or pharmacist before taking Zolmitriptan, as its effects during these times are not well understood. Always read the packaging and Patient Information Leaflet for guidance and inform your doctor of any other medications you are taking.

Download patient leaflet

https://www.medicines.org.uk/emc/files/pil.9924.pdf

Checked By
Dr Sarah Thornton
MbChB, Coaching Academy diploma with distinction

Medical coaching


Written By
Shazlee Ahsan
BSc Pharmacy, Independent Prescriber, PgDip Endocrinology, MSc Endocrinology, PgDip Infectious Diseases

Independent prescriber, Superintendent pharmacist.


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